郑希耕

中国科学院心理研究所

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  • 郑希耕
  • 副研究员
  •   北京市朝阳区林萃路16号院中国科学院心理所
简历:
43岁中国科学院心理研究所心理健康院重点实验室/实验临床心理学研究室副研究员,专业方向:基础心理学(生物心理学)主要研究领域:应激相关精神疾病的行为及脑机制研究;在上述相关领域,发表科研论文30余篇,多篇被SCI/SSCI/CSA等国际文献检索系统收录,现任中国心理学会生理心理学会专业委员会委员,中国科学院心理所学位委员会委员,中国科学院心理所实验伦理委员会委员,《心理科学进展》杂志编委
研究领域:
应激相关精神疾病的行为及脑机制研究。
社会任职:
获奖及荣誉:
1.《大鼠成瘾易感性行为学特征及脑内相关基因表达的研究》,2005年度全国优秀博士学位论文提名。2005.122.《社会拥挤状态对吗啡精神兴奋性效应及其个体差异的调控》获第八届北京科学技术协会青年优秀科技论文评选二等奖。2005.123.《Susceptibility to Morphine: High vs. Low responders Model》获2004-2005北京神经科学学会年会青年优秀论文奖。2005.14.《大鼠成瘾易感性行为学特征及脑内相关基因表达的研究》,中国科学院首届优秀博士学位论文奖。2004.105.中国科学院心理研究所所长奖一等奖。2003
代表论著:

(* 通讯作者)1. Xigeng Zheng,‡, Olivier Deschaux, Jennifer Lavigne, Ophélie Nachon, Carine Cleren, Jean-Luc Moreau, René Garcia, Prefrontal tetanic stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear, Neurobiology of Learning & Memory, 2013; 101:33-38 (‡: co-first author)2. Olivier Deschaux‡, Xigeng Zheng‡, Jennifer Lavigne, Ophélie Nachon, Carine Cleren, Jean-Luc Moreau, René Garcia, Post-extinction fluoxetine treatment prevents both sub-conditioning procedure-provoked and acute stress-provoked reemergence of extinguished fear, Pychopharmacology, 2013; 225(1): 209-216 (‡: co-first author)3. Xian-Li An, Xi-Geng Zheng*, Jing Liang, and Yun-Jing Bai, Corticosterone combined with intramedial prefrontal cortex infusion of SCH 23390 impairs the strong fear response in high-fear-reactivity rats, Psych Journal, 2012 (Accepted)4. Bai Yunjing, Peng Yonghua, Liang Jing, Zheng Xigeng*, Differential patterns of Neuronal Activation in Rostral versus Caudal Ventral Tegmental Area Involved in Behavioral Sensitization Induced by an Escalating Dose Morphine Administration Paradigm, European Journal of Pharmarcology, 2012; 689:118-1245. Ding, X., Liang, J., Zheng, X., Bai, Y. Liu, Z., Li, Y., Xing, X., Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine, European Journal of Pharmacology, 2013 (accepted)6. Jing Liang, Xigeng Zheng*; Jihuan Chen, Yingying Li, Xiaoli Xing, Yunjing Bai, Yingcong Li, Roles of BDNF, dopamine D3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization, European Neuropsychopharmacology, 2011; 21:825-8347. Jing Liang, Ji-Huan Chen, Xiao-Hong Chen, Yong-Hua Peng, Xi-Geng Zheng*, Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment, Behavioural Brain Research 2011; 216:321-3318. Youhong Li, Xigeng Zheng*, Jing Liang, Yonghua Peng, Coexistence of Anhedonia and Anxiety-independent Increased Novelty-seeking Behavior in the Chronic Mild Stress Model of Depression, Behavioural Processes, 2010; 83:331-3399. LIANG Jing, PENG YongHua, GE XiaoXiang, ZHENG XiGeng*. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects. Chinese Science Bulletin, 2010; 55(3):1-510. Bai, Y. J., Li, Y. H., Zheng, X. G., Han, J., Yang, X. Y., Sui, N. Orexin A attenuates unconditioned sexual motivation in male rats, Pharmacology Biochemistry Behavior, 2009; 91:581-58911. Li Yonghui, Zheng Xigeng, Bai Yunjing, Yang Xiaoyan, Sui Nan, Opposite Effects of MK-801 on The Expression of Food and Morphine -induced Conditioned Place Preference in Rats, Journal of Psychopharmacology, 2006; 20(1):40-4612. Ya Yang‡, Xigeng Zheng‡, Yongfu Wang, Jun Cao, Zhifang Dong, Jingxia Cai, Nan Sui, Lin Xu. Stress Enables Synaptic Depression in CA1 Synapses by Acute and Chronic Morphine: Possible Mechanisms for Corticosterone on Opiate Addiction, The Journal of Neuroscience, 2004; 24(10):2412-20. (‡: co-1st author)13. Zheng Xigeng, Li Yonghui, Luo Xiaojing, Xiao Lin, Wang Dongmei, Liu Jie, Yang Xiaoyan, Sui Nan. Social crowding sensitizes high-responding rats to psychomotor stimulant effects of morphine Pharmacology Biochemistry and Behavior 2004; 79:213-814. X. G. Zheng, B. P. Tan, X. J. Luo, W. Xu, X. Y. Yang, N. Sui. Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood Behavioural Processes 2004; 65(1):15-2315. Zheng Xigeng, Ke Xue, Tan Beiping, Luo Xiaojing, Xu Wei, Yang Xiaoyan, Sui Nan. Susceptibility to Morphine Place Conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats Pharmacology Biochemistry and Behavior 2003; 75:929-3516. ZHENG Xi-Geng, LI Xin-Wang, YANG Xiao-Yan, SUI Nan. Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance. Acta Pharmacologia Sinica 2002 (23) 5:476-8017. Tan Beiping, Zheng Xigeng, Sui Nan. Effects of repeated morphine exposure on open-field activity and novelty seeking behavior in a playground maze Acta Psychologia Sinica, 2003;35: 93-9818. Wang DM, Li J, Li YH , Zheng XG, Yang XY, SUI N, Post-training infusions of dopamine receptor antagonist into the basolateral amygdala prevent morphine-induce conditioned place preference, Acta Pharmacologia Sinica, 2006; 27:420-420

更多成果信息请见:http://ir.psych.ac.cn/zhengxg@psych.ac.cn

承担科研项目情况:
1.《“围创伤期”糖皮质激素在条件性恐惧记忆消退中的作用及其与海马、杏仁核pERK及pCREB活动性的关系研究》获中国科学院心理所“中国科学院优秀博士学位论文、院长奖获得者科研启动专项资金”资助(2009.8-2011.8)2.《PTSD条件性恐惧行为的表达及消退的多巴胺神经机制研究》,获中国科学院心理所“科学发展基金资助(2008.5-2010.5),项目批准号:O8CX0930093.《中脑边缘叶多巴胺系统活动性与应激诱发的动物抑郁行为的关系研究》,获国家自然科学基金资助(2008.1-2010.12);项目批准号:307707224.《药物成瘾易感性大鼠脑核团定位及基因表达研究》,获国家自然科学基金资助(2005.1-2007.12);项目批准号:304705785.《中脑边缘叶多巴胺系统活动性与应激诱发的动物抑郁行为的关系研究》,获中国科学院《优秀博士学位论文科研启动专项资金》资助(2008.1-2010.12)。6.《社会应激调控成瘾易感性的脑机制研究》,获中国科学院心理研究所所长研究基金资助(2003.9-2005.9);项目批准号:049。