贺超英

中国科学院植物研究所

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  • 贺超英
  • 研究员
贺超英,男,博士,研究员, 博士生导师。

中国科学院植物研究所研究员,中国科学院大学岗位教授,国家杰出青年科学基金获得者。

1995年在西北师范大学获得理学学士学位;1998年中国林业科学院亚热带林业研究所获得农学硕士学位;2001年在中国科学院遗传研究所获得理学博士学位。2001年10月到德国Max-Planck-Institute for Plant Breeding Research(Cologne)植物分子遗传系从事博士后研究工作,并于2006年5月在该系成立功能进化研究组,共同研究组长;2008年到中国科学院植物研究所系统与进化植物学国家重点实验室工作,成立了功能进化发育生物学研究组。

近年来,在Nat Commun、Plant Cell、Proc Natl Acad Sci USA、Plant J、Plant Physiol、Mol Biol Evol、J Exp Bot、BMC Evol Biol、Genome Biol Evol、Plant Cell Physiol、BMC Plant Biol、Planta等主流杂志发表论文40余篇。

研究方向和内容

研究组主要从事功能进化发育生物学和功能基因组学等方面的研究工作。研究兴趣涉及生物多样性进化的分子机制和重要农(园)艺性状自然变异、驯化和作物设计的分子基础。主要研究内容包括:植物花与果实形态多样性的进化机制、农作物重要基因家族功能进化及其挖掘利用等方面研究。

1. 花与果形态多样性的进化发育机理研究

这部分工作以茄科植物为主要试材,旨在阐明一些进化创新结构起源的分子基础及其相关生物大分子互作网络、复合体和基因家族的功能进化,揭示果实大小等自然变异遗传调控机制,最终理解物种形成和生物多样性的进化机制等科学问题。现拥有大量的茄科植物资源和Physalis floridana的突变体库,因此主要工作包括以反向遗传学的策略来揭示一些重要调控基因家族成员如MADS-box基因在茄科植物形态建成过程中作用和分子分析一些具有进化信息的酸浆突变体。

2. 重要基因家族的功能进化及其挖掘利用研究

瞄准国家发展战略需求,紧密围绕重要农作物如大豆和水稻等的重要目标性状如耐逆性、产量控制和花期调控等,通过比较功能基因组学的研究,旨在挖掘重要功能基因并探讨它们在转基因作物育种设计中的应用前景。主要研究工作包括相关基因的大规模克隆、分子分析和表达研究等,阐明重要转录因子和重要基因家族成员在这些作物中的演化模式及其与相应性状自然变异趋势的相关性研究,从而筛选具有重要育种价值的调控基因和功能基因并进行转基因功能验证分析,进而弄清楚它们作用的分子细节,为农作物新品种培育奠定基础。

学习与工作机会

研究组每年招收1-2名硕士和1-2名博士研究生(含硕博连读生和从优秀推免本科生中直接选拔的直博生),欢迎对本课题组研究方向感兴趣的有志青年学生报考。具体报名考试时间和考试内容,请参照当年中国科学院植物研究所的招生简章和招生目录。研究组也欢迎客座研究人员和博士后的申请。相关事宜请直接与课题组长联系。

研究论文(注*为通讯作者)

2018

Gao HH, Wang Y, Li W, Gu YZ, Lai YC, Bi YD, He CY*. 2018. Transcriptomic comparison reveals genetic variation potentially underlying seed developmental evolution of soybeans. J. Exp. Bot., 69: 5089-5104.

Hao ZZ, Gong PC, He CY*, Lin JX*. 2018. Peptide aptamers to inhibit protein function in plants. Trends Plant Sci., 23: 281-284.

Gong PC, Li J, He CY*. 2018. Exon junction complex (EJC) core genes play multiple developmental roles in Physalis floridana. Plant Mol. Biol., 98: 545-563.

2017

Gu YZ, Li W, Jiang HW, Wang Y, Gao HH, Lai YC, Chen QS, He CY*. 2017. Differential expression of a WRKY gene between wild and cultivated soybeans correlates to seed size.Journal of Experimental Botany 68(11): 2717-2729.

Gong PC, Ao X, Liu GX, Cheng F-Y*, He CY*. 2017. Duplication and whorl-specific downregulation of the obligate AP3-PI heterodimer genes explain the origin of Paeonia lactiflora plants with spontaneous corolla mutation. Plant Cell Physiol. 58(3): 411-425.

2016

Li QX, Huo QD, Wang J, Zhao J, Sun K*, He CY*. 2016. Expression of B-class MADS-box genes in response to variations in photoperiod is associated with chasmogamous and cleistogamous flower development in Viola philippica. BMC Plant Biol. 16: 151.

Wang Y, Gu YZ, Gao HH, Qiu LJ, Chang RZ, Chen SY, He CY*. 2016. Molecular and geographic evolutionary support for the essential role of GIGANTEAa in soybean domestication of flowering time. BMC Evol. Biol.16: 79.

Gu YZ, Xing SL, He CY*. 2016. Genome-wide analysis indicates lineage-specific gene loss during Papilionoideae evolution. Genome Biol. Evol. 8(3): 635-648.

2015

Zhao M, Gu YZ, He LL, Chen QS, He CY*. 2015. Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC Plant Biol. 15: 120.

Zhou H, Cheng F-Y*, Wu J, He CY* .2015. Isolation and functional analysis of Flowering Locus T gene in tree peonies (PsFT). J. Amer. Soc. Hort. Sci. 140(3): 265-271.

Wang L, Li J, Zhao J, He CY* .2015. Evolutionary developmental genetics of fruit morphological variation within the Solanaceae. Front. Plant Sci. 6: 248.

Li ZC, He CY* .2015. Physalis floridana Cell Number Regulator1 encodes a cell membrane-anchored modulator of cell cycle and negatively controls fruit size. J. Exp. Bot. 66(1): 257-270.

Zhang SH, Zhang JS, Zhao J, He CY* .2015. Distinct subfunctionalization and neofunctionalization of the B-class MADS-box genes in Physalis floridana. Planta 241: 387-402.

2014

Gong PC, Quan H, He CY* .2014. Targeting MAGO proteins with a peptide aptamer reinforces their essential roles in multiple rice developmental pathways. Plant J. 80: 905-914.

Wang L, He LL, Li J, Zhao J, Li ZC, He CY*. 2014. Regulatory change at Physalis Organ Size 1 locus correlates to natural variation in tomatillo reproductive organ size. Nat. Commun. 5: 4271.

Gong PC, He CY*. 2014. Uncovering divergence of rice EJC core heterodimer gene duplication reveals their essential role in growth, development and reproduction. Plant Physiol. 165(3): 1047-1061.

Zhao M, He LL, Gu YZ, Wang Y, Chen QS, He CY*. 2014. Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary roles in plant diversification. Genome Biol. Evol. 6 (4): 1000-1012.

Zhang JS, Li ZC, Zhao J, Zhang SH, Quan H, Zhao M, He CY*. 2014. Deciphering the Physalis floridanadouble-layered-lantern1 mutant provides insights into functional divergence of the GLOBOSA duplicates within the Solanaceae. Plant Physiol. 164 (2):748-764.

Zhang JS, Zhao J, Zhang SH, He CY* .2014. Efficient gene silencing mediated by tobacco rattle virus in an emerging model plant Physalis. PLoS ONE9(1): e85534

Gong PC, Zhao M, He CY*. 2014. Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode. PLoS ONE9(1): e84842.

2013

Zhao J, Tian Y, Zhang JS, Zhao M, Gong PC, Riss S, Saedler R, He CY*. 2013. The euAP1 protein MPF3 represses MPF2 to specify floral calyx identity and displays crucial roles in ‘Chinese lantern’ development in Physalis. Plant Cell25(6): 2002-2021.

He LL, Zhao M, Wang Y, Gai JY, He CY*. 2013. Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max.BMC Evol. Biol. 13: 103.

Zhou H, Cheng F-Y*, Wang R, Zhong Y, He CY*. 2013. Transcriptome comparison reveals key candidate genes responsible for the unusual reblooming trait in tree peonies. PLoS ONE8(11): e79996.

2012

Wang L, Li ZC, He CY*. 2012. Transcriptome-wide mining of the differentially expressed transcripts for natural variation of floral organ size in Physalis philadelphica. J. Exp. Bot.63(18): 6457-6465.

Zhang JS, Khan MR, Tian Y, Li ZC, Simone R, He CY*. 2012. Divergences of MPF2-like MADS-domain proteins have an association with the evolution of the inflated calyx syndrome within Solanaceae. Planta 236 (4): 1247-1260.

Khan MR*, Hu J, He CY*. 2012. Plant hormones including ethylene are recruited in calyx inflation in Solanaceous plants. J. Plant Physiol.169(10): 940-948.

2011

He LL, Zhao J, Zhao M, He CY*. 2011. Current development and application of soybean genomics.Front. Biol. 6(4): 337-348.

2010及以前

Zhang JS, Tian Y, Wang L, He CY*. 2010. Functional evolutionary developmental biology (evo-devo) of morphological novelties in plants. J. Syst. Evol. 48 (2): 94-101.

Wunder J, He CY, Hu J, Li M, Varotto C, Saedler H*. 2010. Evolution of plant biodiversity. Acta Hort. 849: 21-32.

He CY*, Tian Y, Saedler R, Efremova N, Riss S, Khan MR, Yephremov A, Saedler H. 2010. The MADS-domain protein MPF1 of Physalis floridana controls plant architecture, seed development and flowering time. Planta231: 767-777.

Khan MR, Hu J, Riss S, He CY, Saedler H*. 2009. MPF2-like-A MADS-box genes control the inflated calyx syndrome in Withania (Solanaceae): roles of Darwinian’s selection. Mol. Biol. Evol.26(11): 2463-2473.

He CY*, Sommer H, Grosardt B, Huijser P, Saedler H*. 2007. PFMAGO, a MAGO NASHI-like factor, interacts with the MADS-box protein MPF2 from Physalis floridana. Mol. Biol. Evol. 24(5): 1229-1241.

He CY, Saedler H*. 2007. Hormonal control of the inflated calyx syndrome, a morphological novelty, in Physalis. Plant J. 49(5): 935-946.

He CY*, Saedler H. 2007. Molecular evolution of a morphological novelty in Solanaceae, the Inflated-Calyx-Syndrome (ICS) in Physalis. Acta Hort. 745: 171-182.

He CY, Saedler H*. 2005. Heterotopic expression of MPF2 is the key to the evolution of the Chinese lantern of Physalis, a morphological novelty in Solanaceae. Proc. Natl. Acad. Sci. USA102 (16): 5779-5784.

He CY, Münster T, Saedler H*. 2004. On the origin of floral morphological novelties. FEBS Lett. 567: 147-151.

Wang BJ, Wang YJ, Wang Q, Luo GZ, Zhang ZG, He CY, He SJ, Zhang JS, Gai JY, Chen SY*. 2004. Characterization of an NBS-LRR resistance gene homologue from soybean. J. Plant Physiol. 161(7): 815-822.

Zhang WK, Wang YJ, Luo GZ, Zhang JS, He CY, Wu XL, Gai JY, Chen SY*. 2004. QTL mapping of ten agronomic traits on the soybean (Glycine max L. Merr.) genetic map and their association with EST markers. Theor. Appl. Genet.108: 1131-1139.

Wang BJ, Zhang ZG, Li XG, Wang YJ, He CY, Zhang JS, Chen SY*. 2003. Cloning and analysis of a disease resistance gene homolog from soybean. Act. Bot. Sin. 45(7): 864-870.

He CY, Tian AG, Zhang JS, Zhang ZY, Gai JY, Chen SY*. 2003. Isolation and characterization of a full-length resistance gene homolog from soybean. Theor. Appl. Genet.106: 786-793.

He CY, Zhang JS, Chen SY*. 2002. A soybean gene encoding a proline-rich protein is regulated by salicylic acid, an endogenous circadian rhythm and by various stresses. Theor. Appl. Genet.104: 1125-1131.

He CY, Wang WQ, Dongfang Y, Zhang JS, Chen SY*. 2002. Transcritption regulation of soybean ribulose-1, 5-bisphosphate carboxylase small subunit gene by external factors. Chinese Sci. Bulletin47(1): 37-43.

He CY, Wu XL, Zhang JS, Gai JY, Chen SY*. 2001. Isolation and characterization of a mitochondrial atp6 gene from soybean [Glycine max (L) Merr]. Act. Bot. Sin. 43(1): 51-58.

He CY, Wu XL, Zhang JS, Dongfang Y, Du BX, Zhang ZY, Chen SY*. 2001. Isolation and characterization of a new defense gene from soybean.Sci. in China (C) 44(4): 409-420.

He CY, Zhang ZY, Chen SY*. 2001. Isolation and characterization of soybean NBS analogs. Chinese Sci. Bulletin46(23): 1984-1988.