1976年5月出生于甘肃省天水市，1998年在西北师范大学获学士学位，2001年在兰州大学获硕士学位，2005年在中国科学院植物所获博士学位。2005年至2011年在德国马普发育生物学研究所做博士后研究。2011年到中国科学院植物研究所系统与进化植物学国家重点实验室工作。2012年获得国家自然科学基金委“优秀青年科学基金”项目资助。主要研究工作包括三个方面：1）进化基因组学；2）自交不亲和系统的进化及物种形成；3）自然变异及适应性进化。

主要研究工作：

1. 进化基因组学

利用全基因组测序的手段，结合进化基因组学、群体遗传学及生物信息学等多学科的方法，重点探讨基因组进化的规律和机制，包括基因组大小的变异、基因的重复和丢失、基因的起源、转座子的扩增和丢失等。研究的类群以十字花科的拟南芥及其近缘种以及禾本科的水稻及其近缘种为主。

2. 自交不亲和系统的进化及物种形成

自交不亲和（self-incompatibility, SI）在很多有花植物中都存在，它的遗传决定位点被称为自交不亲和位点（S locus）。植物可以通过排斥自己的或与自己具有类似自交不亲和位点的花粉从而保持异交。通过群体遗传学、比较基因组学及分子遗传学方法来揭示自交不亲和位点进化的基本规律及其对物种形成的贡献。下一步的研究主要从物种形成方面展开，重点探讨生殖隔离的形成机制及其与物种形成的关系。

3. 自然变异及适应性进化

适应性是生物在变化多样的环境中生存下来的最重要的能力。动物在极端环境下可以逃走而植物却不能。从进化生物学、生态学及分子遗传学各个角度来研究自然变异的规律和机制，进而揭示植物如何适应环境

主持和参加的科研项目

[1] “拟南芥近缘种在新环境下的基因组变异及其适应机制”，国家自然科学基金委微进化过程的多基因作用机制重大研究计划培育项目（批准号：91231104，2013.1 - 2015.12），主持人。

[2] “植物的适应性进化”，国家自然科学基金委优秀青年科学基金项目（批准号：31222006，2013.1 - 2015.12），主持人。

[3] “分子模块设计育种创新体系”，中国科学院战略性先导科技专项，（2013 - 2018），参加。

[4] “多倍体荠菜的起源研究”，国家自然科学基金委面上项目（批准号：31470331，2015.1 - 2018.12），主持人。

研究论文(§共同第一作者，* 通讯作者)

2018

Yang L, Wang HN, Hou XH, Zou YP, Han TS, Niu XM, Zhang J, Zhao Z, Todesco M, Balasubramanian S, Guo YL*. 2018. Parallel evolution of common allelic variants confers flowering diversity in Capsella rubella. Plant Cell, 30: 1322-1336.

Li ZW, Hou XH, Chen JF, Xu YC, Wu Q, González J, Guo YL*. 2018. Transposable elements contribute to the adaptation of Arabidopsis thaliana. Genome Biol. Evol., 10:2140-2150.

2017

Wu Q, Han TS, Chen X, Chen JF, Zou YP, Li ZW, Xu YC, Guo YL*. 2017. Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives. Genome Biol 18: 217.

Zou YP, Hou XH, Wu Q, Chen JF, Li ZW, Han TS, Niu XM, Yang L, Xu YC, Zhang J, Zhang FM, Tan DY, Tian ZX, Gu HY, Guo YL*. 2017. Adaptation of Arabidopsis thaliana to the Yangtze River basin. Genome Biol 18: 239.

2016

Li ZW, Chen X, Wu Q, Hagmann J, Han TS, Zou YP, Ge S, Guo YL*. 2016. On the origin of de novo genes in Arabidopsis thaliana populations. Genome Biology and Evolution 8: 2190-2202.

Yan Z, Guan H, Han W, Han TS, Guo YL, Fang J. 2016. Reproductive organ and young tissues show constrained elemental composition in Arabidopsis thaliana. Annals of Botany 117: 431-439.

2015

Han TS, Wu Q, Hou XH, Li ZW, Zou YP, Ge S, Guo YL*. 2015. Frequent introgressions from diploid species contribute to the adaptation of the tetraploid Shepherd’s purse (Capsella bursa-pastoris). Molecular Plant 8: 427-438.

Yan Z, Kim N, Han W, Guo YL, Han TS, Du E, Fang J. 2015. Effects of nitrogen and phosphorus supply on growth rate, leaf stoichiometry, and nutrient resorption of Arabidopsis thaliana. Plant Soil 388: 147-155.

2013

Slotte T, Hazzouri KM, ？gren JA, Koenig D, Maumus F, Guo YL, Steige K, Platts AE, Escobar JS, Newman LK, Wang W, Mandáková T, Vello E, Smith LM, Henz SR, Steffen J, Takuno S, Brandvain Y, Coop G, Andolfatto P, Hu TT, Blanchette M, Clark RM, Quesneville H, Nordborg M, Gaut BS, Lysak MA, Jenkins J, Grimwood J, Chapman J, Prochnik S, Shu S, Rokhsar D, Schmutz J, Weigel D, Wright SI. 2013. The Capsella rubella genome and the genomic consequences of rapid mating system evolution. Nature Genetics 45: 831-835.

Guo YL*. 2013. Gene family evolution in green plants with emphasis on the origination and evolution of Arabidopsis thaliana genes. Plant Journal 73: 941-951.

2012

Guo YL, Todesco M, Hagmann J, Das S, Weigel D. 2012. Independent FLC mutations as causes of flowering time variation in Arabidopsis thaliana and Capsella rubella. Genetics 192: 729-739.

2011

Guo YL, Fitz J, Schneeberger K, Ossowski S, Cao J, Weigel D. 2011. Genome-wide comparison of NB-LRR encoding resistance genes in Arabidopsis.Plant Physiology 157: 757-769.

Guo YL § *, Zhao X§, Lanz C, Weigel D. 2011. Evolution of S-locus region in Arabidopsis thaliana relatives. Plant Physiology 157: 937-946. (§ co-first author, * correspondence author)

Hu TT§, Pattyn P§, Bakker EG, Cao J, Cheng JF, Clark RM, Fahlgren N, Fawcett JA, Grimwood J, Gundlach H, Haberer G, Hollister JD, Ossowski S, Ottilar RP, Salamov A, Schneeberger K, Spannagl M, Wang X, Yang L, Nasrallah ME, Bergelson J, Carrington JC, Gaut BS, Schmutz J, Mayer KFX, Van De Peer Y, Grigoriev IV, Nordborg M, Weigel D*, Guo YL*. 2011. The Arabidopsis lyrata genome sequence and the basis of rapid genome size change. Nature Genetics 43: 476-481. (§ co-first author, * co-correspondence author)

Hollister JD, Smith LM, Guo YL, Ott F, Weigel D, Gaut BS. 2011. Transposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata. Proc. Natl. Acad. Sci. USA 108: 2322-2327.

2010及以前

Wahl V, Brand LH, Guo YL, Schmid M. 2010. Effects of Arabidopsis thaliana FANTASTIC FOUR proteins on shoot meristem size. BMC Plant Biology 10: 285.

Guo YL§, Bechsgaard JS§, Slotte T, Neuffer B, Lascoux M, Weigel D*, Schierup MH*. 2009. Recent speciation of Capsella rubella from C. grandiflora, associated with loss of self-incompatibility and an extreme bottleneck. Proc. Natl. Acad. Sci. USA 106: 5246-5251. (§ co-first author, * co-correspondence author) [For perspectives on this work, see: 1) Pannell JR. 2009. Mating-system evolution: genies from a bottleneck. Current Biology 19(9): R369-R370. 2) Faculty of 1000 Biology: http://f1000.com/1158981]

Tang C, Toomajian C, Sherman-Broyles S, Plagnol V, Guo YL, Hu TT, Clark RM, Nasrallah JB, Weigel D, Nordborg M. 2007. The evolution of selfing in Arabidopsis thaliana. Science 317: 1070-1072. [For a perspective on this work, see Faculty of 1000 Biology: http://f1000.com/1089382]

Guo YL, Ge S. 2006. Advances in the study of systematics and evolution of the tribe Oryzeae (Poaceae). Journal of Systematics and Evolution 44: 211-230.

Guo YL, Ge S. 2005. Molecular phylogeny of Oryzeae (Poaceae) based on DNA sequences from chloroplast, mitochondrial and nucleargenomes. American Journal of Botany 92: 1548-1558. [For a perspective on this work, see Faculty of 1000 Biology: http://f1000.com/1029056]

Guo YL, Ge S. 2004. The utility of mitochondrial nad1 intron in phylogenetic study of Oryzeae with reference to the systematic position of Porteresia. Journal of Systematics and Evolution 42: 333-344.

专著及其他

Ge S, Guo YL, Zhu QH. 2005. Molecular phylogeny and divergence of the rice tribe (Oryzeae), with special reference to the origin of the genus Oryza. In Toriyama K, Heong K L, Hardy B (eds), Rice is life: scientific perspectives for the 21st century. Philippines: IRRI. Pp. 40-44.