定位于工业微生物系统生物学。致力于发展工业微生物的先进研究方法,认知工业微生物的高产抗逆分子基础,设计和创造符合工业化需求的微生物。主要研究方向:1、工业微生物的系统生物学;2、氨基酸工业菌株改造与创制。
发表SCI论文60余篇,申请中国发明专利40余项,已授权12项,PCT专利3项,美日等国授权5项。
代表论著:
1.Dele-Osibanjo T#, Li Q #, Zhang X #, Guo X, Feng J, Liu J, Sun X, Wang X, Zhou W, Zheng P*, Sun J*, Ma Y. Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum. Appl Microb Biotech. 2019
2.Wang W#, Li Q#, Sun C, Cai Z, Zheng X, Guo X, Ni X, Zhou W, Guo Y, Zheng P*, Chen C, Sun J* , Li Y, Ma Y. GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli. Microb Cell Fact. 2019
3.Cairns TC#, Feurstein C#, Zheng X, Zheng P, Sun J*, Meyer V*. A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using aplD in Aspergillus niger. Biotech Biofuels. 2019
4.Zhu C#, Chen J#, Wang Y, Wang L, Guo X, Chen N, Zheng P*, Sun J*, Ma Y. Enhancing 5‐aminolevulinic acid tolerance and production by engineering the antioxidant defense system of Escherichia coli. Biotechnol Bioeng. 2019
5.Zhao J#, Liu C#, Guo X, Wang J, Liu H, Zheng P*, Sun J*, Ma Y. Efficient production of trans-3-hydroxyproline by a bacterial trans-3-proline hydroxylase and characterization of enzymatic properties. Biochem Eng J, 2019, 147:57-61.
6.S Sun D#, Chen J#, Wang Y, Li M, Rao D, Guo Y, Chen N, Zheng P*, Sun J*, Ma Y. Metabolic Engineering of Corynebacterium glutamicum by Synthetic Small Regulatory RNAs. J Industr Microb & Biotech, 2019, 46 (2):203–208.
7.Liu J#, Wang Y #, Lu Y, Ni X, Guo X, Zhao J, Chen J, Dele-Osibanjo T, Zheng P*,Sun J*, Ma Y.Mutations on Peptidoglycan Synthesis Gene ponA Improve Electro-transformation Efficiency of Corynebacterium glutamicum ATCC 13869. Appl Envir Microb,2019, 84(24):e02225-18
8.Zheng X, Yu J, Cairns TC, Zhang L, Zhang Z, Zhang Q, Zheng P*, Sun J*, Ma Y. Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger. Biotech J, 2019, 14(3): 1800315
9.Wang X#, Liu J#, Zhao J, Ni X, Zheng P, Guo X, Sun C, Sun J*, Ma Y. Efficient production of trans-4-hydroxy-L-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli.J Biosci Bioeng, 2018, 126 (4):470-477.
10.Liu C#, Zhao J#, Liu J, Guo X, Rao D, Liu H, Zheng P*, Sun J*, Ma Y. Simultaneously improving the activity and thermostability of a new proline 4-hydroxylase by loop grafting and site-directed mutagenesis. Appl Microb Biotech, 2018, 103 (10):265–277.
11.Tuyishime P#, Wang Y#, Fan L, Zhang Q, Li Q,Zheng P*, Sun J*, Ma Y. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production.Metab Eng, 2018, 49:20-231.
12.Fan L#, Wang Y#, Tuyishime P, Gao N, Li Q, Zheng P*, Sun J*, Ma Y. Engineering Artificial Fusion Proteins for Enhanced Methanol Bioconversion. ChemBioChem, 2018, 19 (23):2465-2471.
13.Zhang Q#, Zheng X#, Wang Y, Yu J, Zhang Z, Dele-Osibanjo T, Zheng P*,Sun J*, Jia S, Ma Y.Comprehensive Optimization of the Metabolomics Methodology for Metabolite Profiling of Corynebacterium glutamicum. Appl Microb Biotech, 2018, 102 (16): 7113-7121.
14.Zheng X, Zheng P, Zhang K, Cairns TC, Meyer V, Sun J*, Ma Y. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger. ACS Synth Biol., 2018, e7b00456.
15.Wang Y#, Liu Y #, Liu J, Guo Y, Fan L, Ni X, Zheng X, Wang M*, Zheng P*, Sun J*, Ma Y. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. Metab Eng, 2018, 47: 200-210
16.Zheng X, Zheng P*,Sun J*, Zhang K, Ma Y.Heterologous and endogenous U6 snRNA promoters enabled CRISPR/Cas9 mediated genome editing in Aspergillus niger.Fung. Biol. Biotech,2018, 5(1):2.
17. Wang Y, Cao G, Xu D, Fan L, Wu X, Ni X, Zhao S, Wang Y, Cao G, Xu D, Fan L, Wu X, Ni X, Zhao S, Zheng P*, Sun J*, Ma Y.A Novel L-Glutamate Exporter of Corynebacterium glutamicum.Appl Enviro Microb, 2018, 84(6):e02691-17.
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