郑平

中国科学院天津工业生物技术研究所

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  • 郑平
  • 研究员
  • 天津空港经济区西七道32号

简历

1989.09-1993.07 山东大学微生物系,微生物工程专业,学士

1993.09-1996.07 山东大学微生物系,微生物学专业,硕士

1996.07-2000.09 齐鲁工业大学(原山东轻工业学院)食品工程系,助教/讲师

2001.10-2006.09 德国不伦瑞克工业大学/德国赫尔姆霍茨传染病研究中心(原德国国家生物工程中心

GBF)生物工程/分子生物学专业,博士

2007.09-2008.06 德国赫尔姆霍茨传染病研究中心系统生物学研究组博士后

2008.07-2014.04 中国科学院天津工业生物技术研究所副研究员

2011.11-2013.07 中国科学院天津工业生物技术研究所技术支撑平台负责人

2014.05-至今中国科学院天津工业生物技术研究所研究员

研究方向:

致力于开发大肠杆菌、谷氨酸棒杆菌、黑曲霉等工业菌株的合成生物学及系统生物学工具,利用多组学技术破译工业环境压力下菌株的代谢和调控机制,揭示菌株生理调控和高产机制之间的关系,创制利用淀粉糖、甲醇生产氨基酸、有机酸等大宗和精细化学品的高效工业菌株。先后在Metabolic Engineering、ACS Synthetic Biology、Biotechnology for Biofuels、AEM等国际学术期刊上发表SCI论文30余篇,申请中国发明专利30余项,PCT专利3项,获得中国专利授权10项,日美等国际专利授权5项。

代表论著:

1.Dele-Osibanjo T#, Li Q #, Zhang X #, Guo X, Feng J, Liu J, Sun X, Wang X, Zhou W, Zheng P*, Sun J*, Ma Y. Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum. Appl Microb Biotech. 2019

2.Wang Y#, Liu Y#, Li J, Yang Y, Ni X, Cheng H, Huang H, Guo Y, Ma H, Zheng P*, Wang M*, Sun J, Ma Y. Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum.Biotech Bioeng. 2019

3.Wang W#, Li Q#, Sun C, Cai Z, Zheng X, Guo X, Ni X, Zhou W, Guo Y, Zheng P*, Chen C, Sun J* , Li Y, Ma Y. GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli. Microb Cell Fact. 2019

4.Cairns TC#, Feurstein C#, Zheng X, Zheng P, Sun J*, Meyer V*. A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using aplD in Aspergillus niger. Biotech Biofuels. 2019

5.Zhu C#, Chen J#, Wang Y, Wang L, Guo X, Chen N, Zheng P*, Sun J*, Ma Y. Enhancing 5‐aminolevulinic acid tolerance and production by engineering the antioxidant defense system of Escherichia coli. Biotechnol Bioeng. 2019

6.Cairns TC, Zheng X, Ping Zheng, Sun J*, Meyer V*. Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories. Biotechnol Biofuels. 2019

7.Zhao J#, Liu C#, Guo X, Wang J, Liu H, Zheng P*, Sun J*, Ma Y. Efficient production of trans-3-hydroxyproline by a bacterial trans-3-proline hydroxylase and characterization of enzymatic properties. Biochem Eng J, 2019, 147:57-61.

8.Sun D#, Chen J#, Wang Y, Li M, Rao D, Guo Y, Chen N, Zheng P*, Sun J*, Ma Y. Metabolic Engineering of Corynebacterium glutamicum by Synthetic Small Regulatory RNAs. J Industr Microb & Biotech, 2019, 46 (2):203–208.

9.Liu J#, Wang Y #, Lu Y, Ni X, Guo X, Zhao J, Chen J, Dele-Osibanjo T, Zheng P*,Sun J*, Ma Y.Mutations on Peptidoglycan Synthesis Gene ponA Improve Electro-transformation Efficiency of Corynebacterium glutamicum ATCC 13869. Appl Envir Microb,2019, 84(24):e02225-18

10.Zheng X, Yu J, Cairns TC, Zhang L, Zhang Z, Zhang Q, Zheng P*, Sun J*, Ma Y. Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger. Biotech J, 2019, 14(3): 1800315

11.Wang X#, Liu J#, Zhao J, Ni X, Zheng P, Guo X, Sun C, Sun J*, Ma Y. Efficient production of trans-4-hydroxy-L-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli.J Biosci Bioeng, 2018, 126 (4):470-477.

12.Liu C#, Zhao J#, Liu J, Guo X, Rao D, Liu H, Zheng P*, Sun J*, Ma Y. Simultaneously improving the activity and thermostability of a new proline 4-hydroxylase by loop grafting and site-directed mutagenesis. Appl Microb Biotech, 2018, 103 (10):265–277.

13.Tuyishime P#, Wang Y#, Fan L, Zhang Q, Li Q, Zheng P*, Sun J*, Ma Y. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production.Metab Eng, 2018, 49:20-231.

14.Fan L#, Wang Y#, Tuyishime P, Gao N, Li Q, Zheng P*, Sun J*, Ma Y. Engineering Artificial Fusion Proteins for Enhanced Methanol Bioconversion. ChemBioChem, 2018, 19 (23):2465-2471.

15.Zhang Q#, Zheng X#, Wang Y, Yu J, Zhang Z, Dele-Osibanjo T, Zheng P*,Sun J*, Jia S, Ma Y.Comprehensive Optimization of the Metabolomics Methodology for Metabolite Profiling of Corynebacterium glutamicum. Appl Microb Biotech, 2018, 102 (16): 7113-7121.

16.Kou F, Zhao J, Liu J, Sun C, Guo Y, Tan Z, Cheng F, Li Z, Zheng P*, Sun J. Enhancement of the thermal and alkaline pH stability of Escherichia coli lysine decarboxylase for efficient cadaverine production. Biotech Lett. 2018, 40(4):719-727

17.Xu D#, Zhao J#, Cao G, Wang J, Li Q, Zheng P*, Zhao S, Sun J. Removal of feedback inhibition of Corynebacterium glutamicum phosphoenolpyruvate carboxylase by addition of a short terminal peptide. Biotech Bioproc Eng. 2018, 23(1):72-78

18.Zheng X, Zheng P, Zhang K, Cairns TC, Meyer V, Sun J*, Ma Y. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger. ACS Synth Biol., 2018, e7b00456.

19.Wang Y#, Liu Y #, Liu J, Guo Y, Fan L, Ni X, Zheng X, Wang M*, Zheng P*, Sun J*, Ma Y. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. Metab Eng, 2018, 47: 200-210.

20.Zheng X, Zheng P*,Sun J*, Zhang K, Ma Y.Heterologous and endogenous U6 snRNA promoters enabled CRISPR/Cas9 mediated genome editing in Aspergillus niger.Fung. Biol. Biotech,2018, 5(1):2.

21. Wang Y, Cao G, Xu D, Fan L, Wu X, Ni X, Zhao S, Zheng P*, Sun J*, Ma Y.A Novel L-Glutamate Exporter of Corynebacterium glutamicum.Appl Enviro Microb, 2018, 84(6):e02691-17

承担科研项目情况:

主持国家重点研发计划课题、国家自然科学基金面上项目、国家863计划课题、天津市科技支撑计划、中国科学院知识创新工程项目、企业横向项目等10余项科研项目。

获奖及荣誉:

2017年获天津市三八红旗手

2014年中国产学研合作创新成果奖