- 李建军
- 无
- 副研究员
- 北京市海淀区中关村北二街一号

博士,副研究员,硕士生导师。2001年7月于中国科学院化学研究所获得博士学位。2001年11月至2007年12月在英国华威大学 (University of Warwick) 化学系从事博士后研究,2007年12月至2009年12月在英国Illumina 公司蛋白工程部工作,2009年12月至2014年5月在中国科学院青岛生物能源与过程研究所工作,2014年6月到中国科学院过程工程研究所工作。已发表SCI论文18篇,申请国家发明专利4项(2项已授权)。目前主持国家自然科学基金面上(两项)、中国科学院重点部署项目子课题(一项)等项目。
研究方向:
1、新型糖苷酶的酶学(酶的结构-功能关系及催化机理研究)与蛋白质工程(理性设计、定向进化)研究;
2、糖苷酶库的构建及应用开发。
代表性文章
1.Huang, X, Lu, X, Li, Y, Zhang, X, Li, X, Li, J-J*, “Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain”, Microb. Cell Fact., 2014, 13, 119.
2.Huang, X, Lu, X, Li, Y, Zhang, X, Li, X, Li, J-J*, “Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus”, Microb. Cell Fact., 2014, 13, 108.
3.Wang, Q, Huang, X, Zhang, J, Lu, X, Li, S, Li, J-J*, “Engineering self-sufficient aldehyde deformylating oxygenase fused to alternative electron transfer systems for efficient conversion of aldehydes into alkanes”, Chem. Commun., 2014, 50, 4299-4301.
4.Zhang, J, Lu, X*, Li, J-J*, “Conversion of fatty aldehydes into alk(a/e)nes by in vitro reconstituted cyanobacterial aldehyde deformylating oxygenase with a cognate electron transfer system”, Biotechnol. Biofuels, 2013, 6, 86.
5.Bao, X, Huang, X, Lu, X, Li, J-J*, “Improvement of H2O2 stability of Pleurotus eryngii versatile peroxidise through rational protein engineering”, Enzyme Microb. Tech., 2014, 54, 51-58.
6.Huang, X, Lu, X, Li, J-J*, “Cloning, characterization and application of a glyceraldehyde-3-phosphate dehydrogenase promoter from Aspergillus terreus”, J. Ind. Microbiol. Biot., 2014, 41, 585-592.
7.Li, J-J, Bugg, TDH*, “Investigation of a general base mechanism for ester hydrolysis in C–C hydrolase enzymes of the α/β-hydrolase superfamily: a novel mechanism for the serine catalytic triad”, Org. Biomol. Chem., 2007, 5, 507-513.
8.Li, J-J, Li, C, Blindauer, CA, Bugg, TDH*, “Evidence for a gem-diol reaction intermediate in bacterial C-C hydrolase enzymes BphD and MhpC from 13C NMR spectroscopy”, Biochemistry, 2006, 45, 12461–12469.
9.Li, J-J, Bugg, TDH*, “Stereochemistry of the reaction catalysed by 2-hydroxy-6-keto-6-phenyl-hexa-2,4-dienoic acid 5,6 hydrolase (BphD)”, Chem. Commun., 2005, 130-132.
10.Li, J-J, Bugg, TDH*, “A fluorescent analogue of UDP-N-acetylglucosamine: application for FRET assay of peptidoglycan translocase II (MurG)”, Chem. Commun., 2004, 182-183.