王 宇

中国科学院动物研究所

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  • 王 宇
  • 研究员
  • 北京市海淀区北四环西路25-1号中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100190
姓 名: 王 宇
学 科: 干细胞与再生生物学
电话/传真: +86-10-82619461 /
电子邮件: wangyuATioz.ac.cn (Please replace AT with @)
通讯地址: 北京市海淀区北四环西路25-1号中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100190
更多信息: 干细胞与小分子调控研究组

简历介绍:

王宇,男,博士,研究员,博士生导师;干细胞与生殖生物学国家重点实验室干细胞与小分子调控实验室负责人。 王宇博士2004年本科毕业于中国科学技术大学,2010年博士毕业于哈佛大学化学与化学生物学系,师从Andrew P. McMahon教授,2010年起于哈佛大学和Morgridge研究所分别做博士后研究,先后师从于Lee L. Rubin教授和James A. Thomson教授。目前,有多篇论文发表于国际重要学术期刊PNAS,JACS、Nucleic Acids Research,Cell Chemical Biology,Molecular Therapy-Nucleic Acids, ACS Chemical Biology,Current Opinion in Cell Biology等,另外持有2项关于蛋白标记、药物筛选技术、候选药物分子结构的PCT及美国专利,申请4项关于药物诱导的基因编辑和调控系统的发明专利。

研究领域:

王宇实验室专注于小分子药物和干细胞生物学两个领域的融合交叉研究,我们致力于应用药物发现的技术发现再生医学和癌症的新机制、新靶点,进而开发新药物。同时,我们对于开发新颖有趣的化学生物学技术有浓厚兴趣。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

Zhao, C1., Zhao, Y1., Zhang, J1., Lu, J., Chen, L., Zhang, Y., Ying, Y., Xu, J. Wei, S., Wang, Y.* (2018) HIT-Cas9: a CRISPR/Cas9 Genome Editing Device Under Tight and Effective Drug Control. Molecular Therapy-Nucleic Acids. 1(13): 208-219.Zhao, C1., Zhang, Y1., Zhao, Y., Ying, Y., Ai, R., Zhang, J., Wang, Y.* (2018) Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation. ACS Chemical Biology. 13(3): 609-617.Lu, J1., Zhao, C1., Zhao, Y1., Zhang, J1., Zhang, Y., Chen, L., Han, Q., Ying, Y., Peng, S., Ai, R., Wang, Y.* (2018) Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing. Nucleic Acids Research 46(5): e25Liu, L., Zhang, J., Rheindt, F.E., Lei, F., Qu, Y., Wang, Y., Zhang, Y., Sullivan, C., Nie, W., Wang, J., Yang, F., Chen, J., Edwards, S.V., Meng, J., Wu, S., (2017) Genomic Evidence Reveals a Radiation of Placental Mammals Uninterrupted by the KPg Boundary. PNAS 114 (35):E7282-E7290.Wu, F., Zhang, Y., Sun, B., McMahon, A.P., Wang, Y.* (2017) Hedgehog Signaling: From Basic Biology to Cancer Therapy. Cell Chemical Biology. 24 (3): 252-280.Ding, H., Yang, D., Zhao, C., Song, Z., Liu, P., Wang, Y., Chen, Z., Shen, J. (2015) Protein?Gold Hybrid Nanocubes for Cell Imaging and Drug Delivery. ACS Appl. Mater. Interfaces 7 (8): 4713–4719.Schwartz, M.P., Hou, Z., Propson, N.E., Zhang, J., Engstrom, C.J., Costa, V.S., Jiang, P., Nguyen, B.K., Bolin, J.M., Daly, W., Wang, Y., Stewart, R., Page, C.D., Murphy, W.L., and Thomson, J.A. (2015) Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. PNAS 112 (40): 12516-12521.Wang, Y.*, and McMahon, A.P. (2013). A novel site comes into sight. eLife2, e01680.Wang, Y., Davidow, L., Arvanites, A.C., Blanchard, J., Lam, K., Xu, K., Oza, V., Yoo, J.W., Ng, J.M., Curran, T., Rubin, L.L. *, and McMahon, A.P*. (2012b). Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chemistry & biology19, 972-982.Wang, Y., Arvanites, A.C., Davidow, L., Blanchard, J., Lam, K., Yoo, J.W., Coy, S., Rubin, L.L. *, and McMahon, A.P*. (2012a). Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS chemical biology7, 1040-1048.Wang, Y., Zhou, Z., Walsh, C.T. *, and McMahon, A.P. * (2009). Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. PNAS106, 2623-2628.Wang, Y.1, McMahon, A.P. *, and Allen, B.L. 1 (2007). Shifting paradigms in Hedgehog signaling. Current opinion in cell biology19, 159-165.

专利:

Wang Y and McMahon AP (2013). System for screening agonists/antagonists of cellular signaling pathways. US Patent 8,574,837.Wang Y, McMahon AP, and Rubin LL (2013). Modulators of Hedgehog signaling pathway. US Patent App. 20,130,274,233.王宇,卢佳,赵晨,张竞方, (2017)用于基因转录激活的药物诱导型CRISPR/Cas9系统, 中国发明专利申请, 201710553184.8王宇,赵晨,卢佳,赵迎泽,张竞方, (2017)用于基因组编辑和转录调控的药物诱导型CRISPR/Cas9系统, 中国发明专利申请, 201710553178.2王宇,赵晨,张月, (2017)用于基因组编辑的药物诱导型融合蛋白及其编码基因与应用, 中国发明专利申请, 201710549795.5,王宇,赵晨,张月, (2017)一种药物诱导的基因转录激活方法,中国发明专利申请, 201710553173.X

写给考生的话:

“Mind and Hand” – MIT’s motto.