林建平

中国科学院天津工业生物技术研究所

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  • 林建平
  • 研究员
  • 天津空港经济区西七道32号
简历

1、学习经历:

2001/8 – 2005/07,美国杜克大学,化学系,博士

2000/8 – 2001/7,美国匹兹堡大学,化学院,博士研究生

1997/09 – 2000/07,北京大学,化学院,硕士

1992/09 – 1997/07,北京大学,化学院,本科

2、工作经历:

2009/12 – 至今,南开大学,药学院,教授

2006/03 – 2009/11,美国希望之城医学中心,贝克曼研究所,博士后

2005/08 – 2006/02,美国杜克大学,化学系,博士后

研究方向:

计算生物学

1.酶的全新设计

2.与酶相关数据库建设、挖掘及模型建立

3.酶反应机制理论模拟

4.与电能细胞相关蛋白设计

代表论著:

1、论文

[1] Jianping Lin*; Pi Liu; Hua-ZhengYang; Nagarajan Vaidehi*, Factors That Affect the Computational Prediction of Hot Spots in Protein-Protein Complexes, Comput. Mol. Biosci., 2, pp23-34, 2012.

[2] Ralf Buettner; Renzo Corzano; Rumana Rashid; Jianping Lin; Maheswari Senthil; Michael Hedvat; Anne Schrodinger; Allen Mao; Andreas Herrmann; John Kim; Hongzhi Li; Yate-Ching Yuan; Kenichi Yakushijin; Fumiko Yakushijin; Nagarajan Vaidehi; Roger Moore; Gabriel Gugiu; Terr D Lee; Richard Yip; Yuan Chen; Richard Jove*; David Horne*; John C Williams*, Alkylation of cycteine 468 in Stat3 defines a novel site for therapeutic development, ACS Chem. Biol., 6(5), pp432-443, 2011.

[3] Jianping Lin; Ralf Buettner; Yate-Ching Yuan; Richard Yip; David Horne; Richard Jove; Nagerajan Vaidehi*, Molecular dynamics simulations of the conformational changes in Signal Transducers and Activators of Transcription, Stat1 and Stat3, J. Mole. Graphics Model., 28(4), pp347-356, 2009.

[4] Jianping Lin; Nadrian C. Seeman; Nagarajan Vaidehi*, Molecular dynamics simulations of insertion of chemically modified DNA nanostructures into water-chloroform interface, Biophys. J., 95(3), pp1099-1107, 2008.

[5] Jianping Lin; Ilya A. Balabin; David N. Beratan*, The Nature of Aqueous Tunneling Pathways between Electron-transfer Proteins, Science, 310(5752), pp1311-1313, 2005. related news: “Water can ease electron transfer between proteins” Chemical & Engineering News November 28, 2005. Page 11.

[6] Jianping Lin; David N. Beratan*, Simulation of Electron transfer between Cytochrome c2 and the Bacterial Photosynthetic Reaction Center: Brownian Dynamics Analysis of the Native Proteins and Double Mutants, J. Phys. Chem. B, 109(15), 7529-7534, 2005.

[7] Jianping Lin; David N. Beratan*, Tunneling while Pulling: The Dependence of Tunneling Current on End-to-End Distance in a Flexible Molecule, J. Phys. Chem. A, 108(5752), 5655-5661, 2004.

2、专著:

[1] James C. Sung; Jianping Lin, Diamond Nanotechnology: Synthesis and applications. Pan Stanford Publishing, 2009.

[2] Spiros S. Skourtis; Jianping Lin; David N. Beratan, The Effects of Bridge Motion on Electron Transfer Reactions Mediated by Tunneling, Chapter 18 in Modern Methods for Theoretical Physical Chemistry of Biopolymers. Edited By E. B. Starikov; S. Tanaka; J. P. Lewis, Elsevier Press, June 2006.