郭良宏

中国科学院生态环境研究中心

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  • 郭良宏
  • 研究员
  • 北京海淀区双清路18号
简历:

1980-1985 中国科学技术大学应用化学系,本科

1985-1987武汉大学化学系,研究生

1987-1990英国牛津大学无机化学系,博士

1991-1995美国罗切斯特大学(University of Rochester)化学系,博士后

1995-2001美国IGEN生物技术公司

2001-2004北京国家生物芯片研究工程中心

2004-现在中国科学院生态环境研究中心,研究员

研究方向:

环境分子毒理与环境生物分析方法

招生方向:
专家类别:
杰出青年; 百人计划入选者; 研究员
职务:
大气环境化学与健康联合实验室主任
社会任职:

Environmental Science: Processes and Impacts副主编

《环境化学》主编

《分析化学》编委,

《生态毒理学报》编委

承担科研项目情况:

(1)国家基金委重大研究计划重点项目:“基于颗粒物模型研究PM2.5氧化应激效应的分子机制”,2016.01-2017.12

(2)国家基金委面上项目:“DNA损伤的电化学发光传感检测方法与应用研究”,2014.01-2017.12

(3)国家科技部重大科学研究计划项目(973项目):“纳米材料的水处理器件化方法及其应用基础研究”,2010.10-2015.08

(4)国家基金委面上项目:“基于酪氨酸电化学的蛋白质磷酸化检测” ,2009.01-2011.12

(5)国家基金委杰出青年基金项目:“生物分析化学” ,2009.01-2012.12

(6)国家基金委重大项目课题:“典型持久性污染物的累积代谢及其与生物分子的相互作用” ,2009.01-2012.12

(7)中国科学院重大科研装备研制项目:“环境化合物遗传毒性快速检测仪” ,2008.03-2010.06

(8)国家科技部高技术研究发展计划(863)项目:“环境中具有遗传毒性化学污染物的光电化学快速筛查技术” ,2007.01-2009.12

(9)国家基金委面上项目:“电化学方法研究环境化合物与核酸的相互作用及其基因毒理” ,2007.01-2009.12

(10)中国科学院“百人计划”项目:“生物分析与生态毒理” ,2004.06-2007.05

获奖及荣誉:

2009中国科学院优秀研究生指导教师奖

2013中国科学院杰出科技成就奖

2013国家百千万人才工程“有突出贡献中青年专家”

2014英国皇家化学学会会士(FRSC)

代表论著:

(94) Hui Zhang , Liang-Hong Guo,* Lixia Zhao, Bin Wan, and Yu Yang

“Switching Oxygen Reduction Pathway by Exfoliating Graphitic Carbon Nitride for Enhanced Photocatalytic Phenol Degradation”

J. Phys. Chem. Lett. 2015, 6, 958?963.

(93) Yiping Wu, XiqiangYang, BintianZhang, Liang-HongGuo*

“An Electrochemiluminescence Biosensor for 8-oxo-7,8-Dihydro-2-deoxyguanosine Quantification and DNA Repair Enzyme Activity Analysis Using a Novel Bifunctional Probe”

Biosensors and Bioelectronics, 2015, 69. 235–240.

(92) Hui Zhang, Liang-Hong Guo,* Dabin Wang, Lixia Zhao, and Bin Wan

“Light-Induced Efficient Molecular Oxygen Activation on a Cu(II)-Grafted TiO2/Graphene Photocatalyst for Phenol Degradation”

ACS Appl. Mater. Interfaces, 2015, 7, 1816?1823.

(91) Qiyan Lv, Bin Wan,* Liang-Hong Guo,* Lixia Zhao,Yu Yang

“In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction”

Chemosphere. 2015, 120, 621-630.

(90) Xiao-Min Ren, Yin-Feng Zhang, Liang-Hong Guo,* Zhan-Fen Qin,* Qi-Yan Lv, Lian-Ying Zhang

“Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor”

Arch. Toxicol. 2015, 89, 233–242.

(89) Jing Sun, Liang-Hong Guo,* Hui Zhang,* Lixia Zhao

“UV Irradiation Induced Transformation of TiO2 Nanoparticles in Water: Aggregation and Photoreactivity”

Environ. Sci. Technol. 2014, 48, 11962?11968.

(88) Dabin Wang, Lixia Zhao,* Liang-Hong Guo,* Hui Zhang

“Online Detection of Reactive Oxygen Species in Ultraviolet (UV)-Irradiated Nano-TiO2 Suspensions by Continuous Flow Chemiluminescence”

Anal. Chem. 2014, 86, 10535?10539.

(87) Dapeng Zhanga, Lei Yin, Zihui Meng, Anchi Yu, Liang-hong Guo, Hailin Wang*

“A sensitive fluorescence anisotropy method for detection of lead (II)ion by a G-quadruplex-inducible DNA aptamer”

Analytica Chimica Acta, 2014, 812, 161– 167.

(86) Sufang Wang, Bin Wan, Lianying Zhang, Yu Yang,* Liang-Hong Guo*

“In vitro inhibition of lysine decarboxylase activity by organophosphate esters”

Biochemical Pharmacology. 2014, 92, 506-516.

(85) Sufang Wang, Qiyan Lv, Yu Yang,* Liang-Hong Guo,* Bin Wan, Lixia Zhao

“Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase”

Science of the Total Environment. 2014, 496, 381-388.

(84) Lianying Zhang, Xiao-Min Ren, Bin Wan, Liang-Hong Guo*

“Structure-dependent binding and activation of per?uorinated compounds on human peroxisome proliferator-activated receptor γ”

Toxicology and Applied Pharmacology. 2014, 279, 275-283.

(83) Lixia Zhao,* Fanglan Gen, Fan Di, Liang-Hong Guo,* Bin Wan, Yu Yang, Hui Zhang

“Polyamine-functionalized carbon nanodots: a novel chemiluminescence probe for selective detection of iron(III) ions”

RSC Adv. 2014, 4:, 45768-45771.

(82) 吴一萍,郭良宏*

“DNA损伤的光电化学传感器检测”

《化学进展》,2014, 26, 1-9.

(81) Qiang Ma*, Hua Bai, Chao Wang, Guang-Cheng Xi, Qing Zhang, Xian-Shuang Meng, Yun-Xia Chen, Jing-Rui Li, Hui-Juan Ma, Liang-Hong Guo*

“Investigation of noncovalent interactions between hydroxylatedpolybrominated diphenyl ethers and bovine serum albumin usingelectrospray ionization-ion mobility-mass spectrometry”

International Journal of Mass Spectrometry, 2014, 357, 34-44.

(80) Jing Sun, Hui Zhang,* Liang-Hong Guo,* and Lixia Zhao

“Two-Dimensional Interface Engineering of a Titania?Graphene Nanosheet Composite for Improved Photocatalytic Activity”

ACS Appl. Mater. Interfaces, 2013, 5, 13035-13041.

(79) 刘世利, 陈守臻, 赵倩, 徐政虎,李玉贾,继辉, 郭良宏*

“光电化学竞争法检测生物素”

《分析化学》,2013, 10, 1477 -1481

(78) Lianying Zhang, Xiao-Min Ren, Liang-Hong Guo*

“Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein”

Environ. Sci. Technol. 2013, 47, 11293?11301.

(77) 李敏杰, 吴一萍, 张斌田, 郭良宏*

“DNA 脱碱基位点的检测与应用”

《分析化学》,2013, 7, 965-972.

(76) Yiping Wu, Bintian Zhang, Liang-Hong Guo*

“Label-Free and Selective Photoelectrochemical Detection of Chemical DNA Methylation Damage Using DNA Repair Enzymes”

Analytical Chemistry,2013, 85, 6908?6914.

(75) P.-X. Dong, B. Wan*, Z.-X. Wang, L.-H. Guo*, Y. Yang, L. Zhao

“Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages”

Nanotoxicology, 2013, 7, 1028-1042.

(74) Wan, B*.; Wang Z. X.; Lv, Q. Y.; Dong, P. X.; Zhao, LX; Yang, Y; Guo, L. H*.

“Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarilycultured murine peritoneal macrophages”

Toxicology Letters, 2013, 221, 118-127.

(73) Li, X. X.; Gao, Y.; Guo, L. H.*; Jiang, G. B.

“Structure-dependent activities of hydroxylated polybrominated diphenyl ethers on human estrogen receptor”

Toxicology, 2013, 309, 15-22.

(72) Zhao, LX.*; Di, F.; Wang, DB.; Guo, L. H.*; Yang, Y.; Wan, B.; Zhang, H.

“Chemiluminescence of carbon dots under strong alkaline solutions: a novel insight into carbon dot optical properties”

Nanoscale, 2013, 5, 2655-2658.

(71) Ren, X. M.; Guo, L. H.*

“Molecular toxicology of polybrominated diphenyl ethers: nuclear hormone receptor mediated pathways”

Environmental Science: Processes & Impacts,2013, 15, 702-708.

(70) Ren, X.M.; Guo, L. H.*; Gao, Y.; Zhang, B. T.; Wan, B.

“Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination”

Toxicology and Applied Pharmacology, 2013, 268, 256-263.

(69) C. Liang, M. Zou*, L.-H. Guo, W. Gui, G. Zhu

“Development of a bead-based immunoassay for detection of triazophos

and application validation”

Food and Agricultural Immunology, 2013, 24, 9-20

(68) Y. Gao, X. Li, L.-H. Guo*

“Assessment of Estrogenic Effects of Perfluoroalkyl Acids by Monitoring Ligand-induced Conformation State of Human Estrogen Receptor”

Environmental Science & Technology, 2013, 47, 634-641.

(67) Y. Gao, L.-H. Guo*

“Development of a Label-free Competitive Ligand Binding Assay with Human Serum Albumin on Molecularly Engineered Surface Plasmon Resonance Sensor Chip”

Analytical Methods, 2012, 4, 3718-3723.

(66) M.-Y. Wei, L.-H. Guo*, P. Famouri

“Electrocatalytic oxidation of tyrosines shows signal enhancement in label-free protein biosensors”

TRAC-Trends in Analytical Chemistry,2012, 39, 130-148.

(65) Z. Fan, Y. S. Keum, Q. X. Li, W. L. Shelver, L.-H. Guo*

“Development of indirect competitive fluorescence immunoassay for 2,2’,4,4’-tetrabromodiphenyl ether using DNA/dye conjugate as antibody multiple labels”

Journal of Environmental Science, 2012, 24, 1334-1340.

(64) B. Zhang, L.-H. Guo*, M. Greenburg*

“Quantification of 8-OxodGuo Lesions in Double-Stranded DNA Using

a Photoelectrochemical DNA Sensor”

Analytical Chemistry,2012, 84, 6048?6053

(63) B. Zhang, L.-H. Guo*

“Highly sensitive and selective photoelectrochemical DNA sensor for the detection of Hg2+ in aqueous solutions”

Biosensor & Bioelectronics, 2012, 37, 112–115.

(62) X. M. Ren, L.-H. Guo*

“Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transport Proteins Using a Site-Specific Fluorescence Probe”

Environmental Science & Technology, 2012, 46, 4633?4640

(61) P. X. Dong, B. Wan*, L.-H. Guo

“In vitro toxicity of acid-functionalized single-walled carbon nanotubes: effects on murine macrophages and gene expression profiling”

Nanotoxicology, 2012, 6, 288-303.

(60) Z. Fan, Y. S. Keum, Q. X. Li, W. L. Shelver, L.-H. Guo*

“Sensitive immunoassay detection of multiple environmental chemicals on protein microarrays using DNA/dye conjugate as a fluorescent label”

Journal of Environmental Monitoring, 2012, 14, 1345–1352.

(59) Q. Ma?, G.-C. Xi, C. Wang, H. Bai, Q. Zhang, H.-W. Xi, L.-H. Guo?

“Comprehensive two-dimensional separation for the analysis of alkylphenol ethoxylates employing hydrophilic interaction chromatography coupled with ion mobility-mass spectrometry”

International Journal of Mass Spectrometry, 2012, 315, 31– 39.

(58) Y. Liu, S. Jia, L.-H. Guo?

“Development of microplate-based photoelectrochemical DNA biosensor array

for high throughput detection of DNA damage”

Sensors and Actuators B, 2012, 161, 334– 340.

(57) M.-Y. Wei, R. Huang, L.-H. Guo*

“High catalytic activity of indium tin oxide nanoparticle modified electrode towards electro-oxidation of ascorbic acid”

Journal of Electroanalytical Chemistry, 2012, 664, 156–160.

(56) Chizhou Liang, Mingqiang Zou,* Liang-hong Guo, Guoyang Huang, Jianfei Lu, Yong Xu, Linfei Shou

“Comparison of Different Elisa Formats for the Detection of Cephalexin and Application Validation”

Analytical Letters, 2012, 45, 1617–1631.

(55) J. Cao, L.-H. Guo*, B. Wan, Y. Wei

“In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A”

Journal of Environmental Sciences, 2011, 23, 315–321.

(54) Y. Yang, L.-H. Guo?, N. Qu, M.-Y. Wei, L.-X. Zhao, B. Wan

“Label-free electrochemical measurement of protein tyrosine kinase activity and

inhibition based on electro-catalyzed tyrosine signaling”

Biosensors and Bioelectronics, 2011, 28, 284– 290.

(53) Q. Ma, C. Wang, H. Bai, H.-W. Xi, G.-C. Xi, X.-M. Ren, Y. Yang, L.-H. Guo*

“Comprehensive Two-Dimensional Separation of Hydroxylated Polybrominated Diphenyl Ethers by Ultra-Performance Liquid Chromatography Coupled with Ion Mobility-Mass Spectrometry”

J. Am. Soc. Mass Spectrom. 2011,

(52) B. Zhang, X. Du, S. Jia, J. He, L.-H. Guo*

“Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor”

Science China: Chemistry, 2011, 54, 1260–1265.

(51) R. Huang, M.-Y. Wei, L.-H. Guo?

“Enhanced electrogenerated chemiluminescence of Ru(bpy)32+ /tripropylamine

system on indium tin oxide nanoparticle modified transparent electrode”

Journal of Electroanalytical Chemistry, 2011, 656, 136–139.

(50) M.-Y. Wei?, L.-H. Guo?, P. Famouri

“DNA biosensors based on metallo-intercalator probes and electrocatalytic amplification”

Microchim Acta, 2011, 172, 247–260

(49) N. Qu, L.-H. Guo?, B.-Z. Zhu?

“An electrochemical biosensor for the detection of tyrosine oxidation induced by

Fenton reaction”

Biosensors and Bioelectronics, 2011, 26, 2292–2296.

(48) 万斌?,郭良宏

“多溴联苯醚的环境毒理研究进展”

《环境化学》,2011, 30,

(47) Yin Wei?, Yuan Lin, Ai-Qian Zhang?, Liang-Hong Guo, Jie Cao

“Evaluation of the noncovalent binding interactions between polycyclic aromatic

hydrocarbon metabolites and human p53 cDNA”

Science of the Total Environment, 2010, 408, 6285–6290.

(46) J. Cao, Y. Lin, L.-H. Guo?, A.-Q. Zhang?, Y. Wei, Y. Yang

“Structure-based investigation on the binding interaction of hydroxylated

polybrominated diphenyl ethers with thyroxine transport proteins”

Toxicology, 2010, 277, 20–28.

(45) R. Huang, L.-R. Wang, L.-H. Guo?

“Highly sensitive electrochemiluminescence displacement method for the study of DNA/small molecule binding interactions”

Anal. Chim. Acta. 2010, 676, 41–45.

(44) R. Huang, L.-H. Guo*

“Lack of nano size effect on electrochemistry of dopamine at a gold nanoparticle modified indium tin oxide electrode”

Sci. China Chem., 2010, 53, 1778–1783.

(43) S. Jia, B.-Z. Zhu, L.-H. Guo*

“Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor”

Anal. Bioanal. Chem. 2010, 397, 2395–2400

(42) 杨郁, 郭良宏*

“超分子主体化合物环糊精应用于环境污染物分离分析的研究进展”

《科学通报》,2009, 54, 128 – 137.

(41) L-R. Wang, Y. Wang, J.-W. Chen?, L.-H. Guo?

“A structure-based investigation on the binding interaction of hydroxylated

polycyclic aromatic hydrocarbons with DNA”

Toxicology, 2009, 262, 250–257.

(40) Q. Zhang, R. Huang, L.-H. Guo?

“One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles”

Chinese Sci Bull, 2009, 54, 2620-2626.

(39)M.-Y. Wei, S.-D. Wen, X.-Q. Yang, L.-H. Guo*

“Development of redox-labeled electrochemical immunoassay for polycyclic aromatic hydrocarbons with controlled surface modification and catalytic voltammetric detection”

Biosensors and Bioelectronics, 2009, 24, 2909–2914.

(38)Y. Wei, L.-H. Guo*

“Binding interaction between polycyclic aromatic compounds and DNA by fluorescence displacement method”

Environmental Toxicology and Chemistry, 2009, 28, 940–945.

(37) 韦明元,郭良宏*

“环境污染物的免疫传感检测方法进展’’

《化学进展》,2009, 21, 492-502.

(36)X.-Q. Yang, L.-H. Guo*

“Enhanced Electrochemical Activity of Redox-labels in Multi-layered Protein Films on Indium Tin Oxide Nanoparticle-based Electrode”

Analytica Chimica Acta, 2009, 21, 373.

(35) Y. Chen, L.-H. Guo*

“Combined fluorescence and electrochemical investigation on the binding interaction between organic acid and human serum albumin”

Journal of Environmental Sciences. 2009, 632, 15.

(34) M. Liang, L.-H. Guo*

“Application of nanomaterials in environmental analysis and monitoring”

Journal of Nanoscience and Nanotechnology. 2009, 9, 2283.

(33) Y. Chen, L.-H. Guo*

“Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin”

Archives of Toxicology. 2009, 83, 255.

(32) N. Qu, B. Wan, L.-H. Guo*

“Label-free electrochemical differentiation of phosphorylation and non-phosphorylated peptides by electro-catalyzed tyrosine oxidation”

The Analyst. 2008, 133, 1246.

(30) L. Wang, N. Qu, L.-H. Guo*

“Electrochemical displacement method for the investigation of the binding interaction of polycyclic organic compounds with DNA”

Analytical Chemistry. 2008, 80, 3910.

(29) S. Jia, M. Liang, L.-H. Guo*

“Photoelectrochemical detection of oxidative DNA damage induced by Fenton reaction with low concentration and DNA-associated Fe2+”

Journal of Physical Chemistry B. 2008, 112, 4461.

(28) S. Zhu, Q. Zhang, L.-H. Guo*

“Part-per-trillion level detection of estradiol by competitive fluorescence immunoassay using DNA/dye conjugate as antibody multiple labels”

Analytica Chimica Acta. 2008, 624, 141.

(27) M. Liang, S. Jia, S. Zhu, L.-H. Guo*

“Photoelectrochemical Sensor for the Rapid Detection of in Situ DNA Damage Induced by Enzyme-Catalyzed Fenton Reaction”

Environmental Science & Technology, 2008, 42, 635.

(26)Q. Zhang, L.-H. Guo*

“Multiple Labeling of Antibodies with Dye/DNA Conjugate for Sensitivity Improvement in Fluorescence Immunoassay”

Bioconjugate Chemistry, 2007, 18, 1668.

(25)M. Liang, L.-H. Guo*

“Photoelectrochemical DNA Sensor for the Rapid Detection of DNA Damage Induced by Styrene Oxide and Fenton Reaction”

Environmental Science & Technology, 2007, 41, 658.

(24) L.-H. Guo*, N. Qu.

“Chemical-Induced Unfolding of Cofactor-Free Protein Monitored by Electrochemistry”.

Analytical Chemistry, 2006, 78, 6275.

(23) M. Liang, S. Liu, M. Wei, L.-H. Guo*

“Photoelectrochemical Oxidation of DNA by Ruthenium Tris(bipyridine) on a Tin Oxide Nanoparticle Electrode”.

Analytical Chemistry. 2006, 78, 621

(22) L.-H. Guo*, M. Wei, H. Chen*

“Multiple DNA Binding Modes of a Metallointercalator Revealed by DNA Film Voltammetry”.

Journal of Physical Chemistry B, 2006, 110, 20568.

(21)M. Wei, L.-H. Guo*, H. Chen*

“Determination of Surface-Immobilized Double-Stranded DNA Using a Metallointercalator and Catalytic Voltammetry”.

Microchimica Acta, 2006, 155, 409.

(20) C. Li, S. Liu, L.-H. Guo*

“A New Chemically Amplified Electrochemical System for DNA Detection in Solution”

Electrochemistry Communications. 2005, 7, 23

(19) L.-H. Guo*, X.-Q. Yang

“A New Chemically Amplified Electrochemical System for the Detection of Biological Affinity Reactions: Direct and Competitive Biotin Assay”

The Analyst. 2005, 130, 1027

(18) D. Dong, D. Zheng, F. Wang, X. Yang, N. Wang, Y. Li, L.-H. Guo*, J. Cheng

“Quantitative Photoelectrochemical Detection of Biological Affinity Reaction: The Biotin-Avidin Interaction”.

Analytical Chemistry. 2004, 76, 499.

(17)G. Yi*, H. Lu, S. Zhao, Y. Ge, W. Yang, D. Chen*, L.-H. Guo*

“Synthesis, characterization, and biological application of size-controlled nanocrystalline NaYF4:Yb,Er infrared-to-visible up-conversion phosphors”.

Nano Letters. 2004, 4, 2191.

(16) H. Lu, G. Yi, S. Zhao, D. Chen*, L.-H. Guo*, J. Cheng

“Synthesis and Characterization of Multi-functional Nanoparticles Possessing Magnetic, Up-conversion Fluorescence and Bio-affinity Properties”

Journal of Materials Chemistry. 2004, 14, 1336.

(15) D. Zheng, N. Wang, F. Wang, D. Dong, Y. Li, X. Yang, L.-H. Guo*, and J. Cheng

“Sensitive Chemically Amplified Electrochemical Detection of Ruthenium Tris-(2,2’-bipyridine) on Tin-doped Indium Oxide Electrode”

Analytica Chimica Acta. 2004, 508, 225.

(14)L. Su, X. Qiu*, L.-H. Guo, F. Zhang, and C. Tung

“Amperometric Glucose Sensor Based on Enzyme-modified Boron-doped Diamond Electrode by Cross-linking Method ”

Sensors and Actuators B. 2004, 99, 499.

(13)L.-H. Guo; G. McLendon*; H. Razafitrimo; Y. Gao.

“Photo-active and electro-active protein films prepared by reconstitution with metalloporphyrins self-assembled on gold”.

Journal of Materials Chemistry. 1996, 6, 369.

(11) H. Razafitrim; E. Ettedgui; Y. Gao*; L.-H. Guo; G. L. McLendon.

“X-ray photoemission study of the interface formation between calcium and self-assembled alkanethiol monolayers”.

Applied Physics Letters. 1995, 67, 2621.

(10) L.-H. Guo; S. Mukamel; G. McLendon*.

'Photophysical probes of a protein/semiconductor electrode interface'.

Journal of the American Chemical Society.1995, 117, 546.

(9) L.-H. Guo*; J.S. Facci; G. McLendon*

'Distance dependence of electron transfer rates in bilayers of a ferrocene Langmuir-Blodgett monolayer and a self-assembled monolayer on gold'.

Journal of Physical Chemistry.1995, 99, 8458.

(8)L-H. Guo; J.S. Facci*; G. McLendon*.

'Effect of structure on the electrochemistry of Langmuir-Blodgett monolayers of 16-ferrocenylhexadecanoic acid on a self-assembled alkanethiol monolayer'.

Journal of Physical Chemistry.1995, 99, 4106.

(7)L.-H. Guo; J. S. Facci*; G. McLendon*; R. Mosher.

'Effect of gold topography and surface pretreatment on the self-assembly of alkanethiol monolayers'.

Langmuir. 1994, 10, 4588.

(6) A. L. Burrows; L.-H. Guo; H. A. O. Hill*; G. L. McLendon; F. Sherman.

'Direct electrochemistry of proteins: investigation of yeast cytochrome c mutants and their complexes with cytochrome b5'.

European Journal of Biochemistry.1991, 202, 543.

(4)L.-H. Guo, H. O. A, Hill*, D. J. Hopper, G. A. Lawrance, G. S. Sanghera

'Direct voltammetry of the Chromatium vinosum enzyme, sulfide:cytochrome coxidoreductase (flavocytochrome c552)'.

Journal of Biological Chemistry.1990, 265, 1958.

(3) S. Bagby; P. D. Barker; L.-H. Guo; H. A. O. Hill*.

'Direct electrochemistry of protein-protein complexes involving cytochrome c, cytochrome b5and plastocyanin'

Biochemistry. 1990, 29, 3213.

(2) L.-H. Guo; H. A. O. Hill*; D. J. Hopper; G. A. Lawrance; G. S. Sanghera.

'Direct unmediated electrochemistry of the enzyme p-cresolmethylhydroxylase'

Journal of Electroanalytical Chemistry.1989, 266, 379.

(1) P. D. Barker; L.-H. Guo; H. A. O. Hill*; G. S. Sanghera.

'The direct, unmediated electrochemistry of protein-protein complexes'

Biochemical Society Transaction. 1988, 16, 957.

Book Chapters

(9) H. Zhang, L.-H. Guo

“Nano-Photo-catalytic Materials for Environmental Applications”

In Aquananotechnology: Global Prospects, Ed. D. E. Reisner, T. Pradeep, CRC Press, FL, USA. 2015, pp 193-216.

(8)R. Huang; L.-H. Guo

'Nanomaterial-based Electrochemiluminescence Biosensors'.

In “Biosensors Based on Nanomaterials and Nanodevices”. Eds. J. Li, N. Wu, CRC Press, FL, USA. 2014, pp 209-242.

(7)史建波,李英明,杨郁,刘景富,蔡亚岐,张庆华,汪海林,郭良宏,江桂斌

'环境分析化学'. 《分析化学学科前沿与展望》,庄乾坤,刘虎威,陈洪渊主编,科学出版社,2011, 442-483.

(6)万斌,郭良宏

'基于毒理基因组学的化合物毒性分类与预测'. 《环境化学学科前沿与展望》,王春霞,朱利中,江桂斌主编,科学出版社,2011, 577-583.

(5) Q. Zhang, S. Zhu, L.-H. Guo

“DNA/Dye conjugates as multiple labels for antibodies in sensitive fluorescence immunoassays”

In Bioconjugation Protocols: Strategies and Methods (2nd edition), Ed. S. S. Mark, Humana Press, 2011, pp 43-54.

(4)郭良宏

'环境污染物与生物大分子的相互作用'. 《10000个科学难题》, “10000个科学难题”化学编委会,科学出版社,2009, 590-592.

(3)郭良宏,邵元华

'可控电化学信号放大方法研究'. 《10000个科学难题》, “10000个科学难题”化学编委会,科学出版社,2009, 437-439.

(2)H. A. O. Hill; L.-H. Guo; G. McLendon

'Direct electrochemistry of cytochrome c'.

In “Cytochrome c: A Multidisciplinary Approach”. eds. R. A. Scott, A. G. Mauk, 1996, pp. 317-333. University Science Books, California.

(1) L.-H. Guo; H. A. O. Hill

'Direct electrochemistry of proteins and enzymes'.

In Advances in Inorganic Chemistry, 1991, Vol. 36 (ed. S.G.Sykes). pp 341-375. Academic Press, Inc. California, USA.