秦占芬

中国科学院生态环境研究中心

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  • 秦占芬
  • 研究员
  • 北京海淀区双清路18号
简历:

2002年中国科学院生态环境研究中心研究生毕业,获得博士学位。之后在中国科学院生物物理所做博士后研究,2004年10月进入生态中心工作至今。长期以两栖动物(国际通用种非洲爪蟾和我国本土种黑斑蛙)为实验动物开展化学品生殖和发育毒理学研究。同时,发展简单易行的化学品毒性识别方法,为我国化学品环境管理提供技术支持。先后承担自然科学基金项目、“863”课题、环保公益项目、中国科学院方向性项目等多项课题。在Environ Health Perspect、Environ Sci Technol等环境类有影响的杂志上发表SCI论文三十多篇,获专利授权1项,编制国家/行业标准多项。

研究方向:
环境激素导致的性逆转及性激素受体介导的作用机制;化学污染物的甲状腺激素信号干扰作用及对脑发育影响的分子机制;化学品毒性识别方法
招生方向:
专家类别:
高级
职务:
社会任职:
承担科研项目情况:

1.中国科学院战略性先导科技专项子课题《甲状腺激素信号介导的化学污染物脑发育毒性研究》(2014.7-2019.7)

2.国家自然科学基金面上项目《双酚类化合物的甲状腺激素信号通路干扰及相关神经毒性》(2014.1-2017.12)

3.国家自然科学基金面上项目《基于两栖动物的全氟辛烷磺酸基化合物替代产品的生态毒理学评价》(2011.1-2013.12)

4.国家自然科学基金面上项目《多溴联苯醚对两栖动物的生态毒理学效应》(2007.1-2009.12)

5.环保公益性行业科研专项项目《基于我国本土生物种的化学品毒性评价方法和管理技术》(2011.1-2013.12)

6.科技部863计划资源环境领域重大项目《化学品风险评估与风险控制技术》中课题《化学品毒性高通量生物测试与评价技术》之子课题(2012.1-2014.12)

获奖及荣誉:
代表论著:

1.Yin-Feng Zhang, Wei Xu, Qin-Qin Lou, Yuan-Yuan Li, Ya-Xian Zhao, Wu-Ji Wei, Zhan-Fen Qin*, Hui-Li Wang*, Jian-Zhong Li. Tetrabromobisphenol A disrupts vertebrate development via thyroid hormone signaling pathway in a developmental stage-dependent manner. Environ Sci Technol, 48(14):8227–8234.

2. Xiao-Min Ren, Yin-Feng Zhang, Liang-Hong Guo*, Zhan-Fen Qin*, Qi-Yan Lv, Lian-Ying Zhang. Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor. Arch Toxicol, 2014, DOI 10.1007/s00204-014-1258-y.

3. Yuan-Yuan Li, We i Xu, Xiao-Ran Chen, Qin-Qin Lou, Wu-Ji Wei, Zhan-Fen Qin *. Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus. DOI:10.1016/j.aquatox.2014.11.017

4. Shan Cao, Wei Xu, Qin-Qin Lou, Yin-Feng Zhang, Ya-Xian Zhao, Wu-Ji Wei*, Zhan-Fen Qin*. Environmental (anti-)androgenic chemicals affect germinal vesicle breakdown (GVBD) of Xenopus laevis oocytes in vitro. Toxicol in vitro, 2014, 28: 426–431.

5. Qin-Qin Lou, Yin-Feng Zhang, Dong-Kai Ren, Hai-Ming Xu, Ya-Xian Zhao, Zhan-Fen Qin*, Wu-Ji Wei. Molecular characterization and developmental expression patterns of thyroid hormone receptors (TRs) and their responsiveness to TR agonist and antagonist in Rana nigromaculata. J Environ Sci, 2014, 26: 2084 – 2094.

6. Ya-Xian Zhao, Xian-Li Ruan, Yan Li, Min-Chan Yan, Zhan-Fen Qin*. Polybrominated diphenyl ethers (PBDEs) in aborted human fetuses and placental transfer during the first trimester of pregnancy. Environ Sci Technol, 2013, 47(11):5939-5946.

7. Qin-Qin Lou, Yin-Feng Zhang, Zhen Zhou, Ya-Li Shi, Ya-Nan Ge, Dong-Kai Ren, Hai-Ming Xu, Ya-Xian Zhao, Wu-Ji Wei*, Zhan-Fen Qin*. Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis. Ecotoxicology, 2013, 22:1133-1144.

8. Peng-Yan Liu, Ya-Xian Zhao, Yi-Yang Zhu, Zhan-Fen Qin*, Xian-Li Ruan, Yong-Chuan Zhang, Bao-Jun Chen, Yan Li, Shi-Shuai Yan, Xiao-Fei Qin, Shan Fu, Xiao-Bai Xu. Determination of polybrominated diphenyl ethers in human semen. Environ Int, 2012, 42:132–137.

9. Peng-Yan Liu, Guo-Dong Du, Ya-Xian Zhao, Yun-Song Mu, Ai-Qian Zhang, Zhan-Fen Qin*, Xiao-You Zhang, Shi-Shuai Yan, Yan Li, Rong-Guo Wei , Xiao-Fei Qin, Yong-Jian Yang. Bioaccumulation, maternal transfer and elimination of polybrominated diphenyl ethers in wild frogs. Chemosphere, 2011, 84:972–978.

10. Rong-Guo Wei, Ya-Xian Zhao, Peng-Yan Liu, Zhan-Fen Qin*, Shi-Shuai Yan, Yan Li, Xiao-Fei Qin, Xi-Juan Xia, Xiao-Bai Xu, Min-Chan Yan. Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies. Toxicol in Vitro, 2010, 24(4):1078-1085.

11. Xiao-Fei Qin, Xi-Juan Xia, Zhong-zhi Yang, Yan Shi-Shuai, Ya-Xian Zhao, Rong-Guo Wei, Yan Li, Mi Tian, Xing-Ru Zhao, Zhan-Fen Qin*, Xiao-Bai Xu. Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis. J Environ Sci, 2010, 22(5):744-751.

12. Zhan-Fen Qin, Xiao-Fei Qin, Lei Yang, Huan-Ting Li, Xing-Ru Zhao, Xiao-Bai Xu*. Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis. Aquat Toxicol, 2007, 84(3):321-327.

13. Lin Cong,Zhan-Fen Qin*, Xiang-Ning jiang,Jing-Ming Zhou, Lei Yang, Xiao-Bai Xu. Xenopus laevis a model animal species to study reproductive toxicity of phytoestrogens. Aquatic Toxicol, 2006, 77(3):250-256.

14. Zhan-Fen Qin, Jing-Ming Zhou,Lin Cong, Xiao-Bai Xu.Potential ecotoxic effects of polychlorinated biphenyls on Xenopus laevis. Environ Toxicol Chem, 2005, 24:2573-2578.

15. Zhan-Fen Qin, Jing-Ming Zhou, Shao-gang Chu, Xiao-Bai Xu. Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis. Environ Health Perspect, 2003, 111(4):553-556.