• 姓      名:    林海燕
• 职      务:   
• 职      称:    副研究员
• 通讯地址:    北京市朝阳区北辰西路1号院5号

简历介绍：

博士，副研究员。1997年和2000年于北京师范大学分别获理学学士和硕士学位。2005年于中国科学院动物研究所获理学博士学位。2006年6月至2008年6月在加拿大不列颠哥伦比亚大学做博士后研究。2016年9月至2017年2月在英国巴布拉汉研究所做访问学者研究。目前主要从事鸟类的适应性进化和分子进化研究，包括发育与免疫进化过程中的性状变化及分子机理。先后主持国家优秀青年基金项目、中加国际合作与交流项目、国家自然科学基金青年科学基金和面上项目、中国科学院知识创新工程领域前沿项目等，国家重点基础研究发展计划研究骨干。迄今在Mol Aspects Med、J Clin Endocrinol Metab、J Biol Chem、Mol Cell Endocrinol等期刊发表论文50余篇，其中第一作者或通讯作者论文20篇。指导已毕业研究生3名。

研究领域：

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

（*，通讯作者） Gu AQ, Li DD, Wei DP, Liu YQ, Ji WH, Yang Y, Lin HY, Peng JP*. Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy. J Cell Mol Med. 2019, 23(8), 5403-5414.Zheng R, Li Y, Sun H, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY*, Wang H. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction,2017, 153, 35-48.Lu X, He Y, Zhu C, Wang H, Chen S*, Lin HY*. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta, 2016, 39, 45-54.Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adhesion & Migration, 2016, 10(1-2), 39-55.Lei JH, Yang XK, Peng S, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab, 2015, 100, 1819-1827.Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, Wang H, Lin HY, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction, 2015, 150, 139-149.Li Y, Zheng R, Wang R, Lu X, Zhu C, Lin HY, Wang H, Yu X*, Fu J*. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction, 2015, 149, 339-346.Zhou Z, Wang R, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta, 2014, 35, 907-918.Wang R, Dang YL, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod, 2014, 90, 117.Chang W, Yang Q, Zhang H, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction, 2014, 148, 343-352.Li W, Liu D, Chang W, Lu XY, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis, 2014, 5, e1025.Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis, 2013, 4, e593.Zhang S#, Lin HY#, Kong S#, Wang S, Wang Hongmei, Wang Haibin*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med, 2013, 34, 939-980.Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 2013, 4, e502.Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS ONE, 2013, 8, e50479.Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab, 2012, 97, E678-E686.Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem, 2012, 113, 3266-3275.Li Y, Wu L, Lei JH, Zhu C, Wang H, Yu XG*, Lin HY*. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci, 2012, 55, 699-708.Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA*. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS ONE, 2012, 7, e52759.Wu L, Zhou HH, Lin HY, Qi JG, Zhu C, Gao ZY*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction, 2012, 143, 389-397.Yang XK, Zhou Y, Peng S, Wu L, Lin HY, Wang SY*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction, 2012, 144, 235-244.Lin HY*, Muller YA, Hammond GL*. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol, 2010, 316, 3-12Fu J, Lv X, Lin HY, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem, 2010, 285, 10870-10879.Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL*. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem, 2009, 284, 884-896.Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY*. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem, 2009, 57, 605-612.Zhang B, Zhou Z, Lin HY, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol, 2009, 132, 169-179.Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta, 2009, 30, 929-938.Zhang H, Lin HY, Yang Q, Wang HX, Chai KX, Chen LM, Zhu C*. Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy. J Histochem Cytochem, 2007, 55, 1237-1244.Yang Q, Lin HY, Wang HX, Zhang H, Zhang XP, Wang H, Zhu C*. Expression of smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy. J Histochem Cytochem, 2007, 55, 453-460.Zhang X, Zhu C, Lin HY, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod, 2007, 77, 358-364.Zhang H, Li Q, Lin HY, Yang Q, Wang H, Zhu C*. Role of PPARgamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro. Neuroendocrinol Lett, 2007, 28, 289-294.Lin HY, Yang Q, Wang H, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C*. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-β1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci, 2006, 11, 637-646.Lin HY, Zhang H, Yang Q, Wang HX, Wang H, Chai KX, Chen LM*, Zhu C*. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. J Histochem Cytochem, 2006, 54, 1139-1147.Lin HY, Qian D, Zhang X, Liu GY, Wang H, Zhu C*. Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci, 2006, 78, 2669-2675.Wang HX, Wang H, Lin HY, Yang Q, Zhang H, Tsang BK, Zhu C*. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol, 2006, 206, 616-623.Liu GY, Zhang X, Lin HY, Wang H, Li QL, Ni J, Zhu C*. Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9. Biochem Biophys Res Commun, 2006, 343, 832-838.Yang Q, Wang HX, Zhao YG, Lin HY, Zhang H, Wang H, Sang QA, Zhu C*. Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci, 2006, 78, 2804-2811.Zhang X, Lin HY, Liu GY, Wang H, Li QL, Zhu C*. Expressions and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy. Front Biosci, 2005, 10, 3172-3182.Wang HX, Zhao YG, Wang H, Yang Q, Lin HY, Sang QA, Zhu C*. Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Mol Hum Reprod, 2005, 11, 429-435.Lin HY, Wang H, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C*. Expression of Smad2 and Smad4, transforming growth factor-β signal transducers, in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci, 2004, 80, 303-316.Qian D, Lin HY, Wang H, Zhang X, Liu DL, Li QL, Zhu C*. Normoxic induction of the hypoxic-inducible factor-1α by interleukin-1β involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells. Biol Reprod, 2004, 70, 1822-1827.Liu G, Lin HY, Zhang X, Li Q, Wang H, Qian D, Ni J, Zhu C*. Expression of Smad2 and Smad4 in mouse uterus during the estrous cycle and early pregnancy. Placenta, 2004, 25, 530-537.Qian D, Lin HY, Wang H, Zhang X, Li QL, Liu DL, Zhu C*. Involvement of ERK1/2 pathway in TGF-β1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev, 2004, 68, 198-204.Zhang X, Wang H, Lin HY, Liu GY, Li QL, Zhu C*. Regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) during mouse peri-implantation: role of nitric oxide. Placenta, 2004, 25, 243-252.Wang H, Zhang X, Qian D, Lin HY, Li QL, Liu DL, Liu GY, Yu XD, Zhu C*. Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9. Biol Reprod, 2004, 70, 481-487.Wang HX, Wang H, Li QL, Lin HY, Qian D, Zhu C*. Expression of proteasome subunits LMP2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta)during early pregnancy. Biol Reprod, 2004, 71, 1317-1324.Lin HY, Wang H, Zhu C*. The Smad pathway in transforming growth factor-beta signaling. Sci China C Life Sci, 2003, 46, 449-463.Wang H, Li QL, Lin HY, Yu XD, Qian D, Dai JJ, Duan EK, Zhu C*. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Mol Reprod Dev, 2003, 65, 123-131.Qian D, Wang H, Lin HY, Zhang X, Li QL, Liu DL, Liu GY, Zhu C*. Effect of UPP on the expression of VEGF and its receptors in mouse uterus during peri-implantation. Chin Sci Bull, 2003, 48, 338-342.Li QL, Wang H, Lin HY, Zhu C*. Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Mol Reprod Dev, 2002, 63, 273-281.Liu DL, Li QL, Lin HY, Liu WZ, Wang H, Zhang X, Zhu C*. Expression and localization of RAP250 mRNA in the rat ovary: Possible implications in follicular development and ovulation. Endocrine, 2002, 18, 173-178.Li QL, Wang H, Lin HY, Shao LJ, Ni J, Duan EK, Zhu C*. Expression of VEGF in the pregnant and postpartrum rat ovaries. Sci China C Life Sci, 2002, 45, 379-387.Zhang X, Wang H, Lin HY, Li QL, Liu DL, Qian D, Liu GY, Zhu C*. Regulation of blastocyst implantation by nitric oxide in mouse. Chin Sci Bul, 2002, 47, 1461-1465.Li QL, Wang H, Zhao YG, Lin HY, Sang QA, Zhu C*. Identification and specific expression of endometase/matrilysin-2 (MMP-26) in endometrium of rhesus monkey during early pregnancy. Mol Hum Reprod, 2002, 8, 934-940.

写给考生的话：