• 姓      名:    翟巍巍
• 职      务:   
• 职      称:    研究员
• 通讯地址:    北京市朝阳区北辰西路1号院5号

简历介绍：

翟巍巍，男，博士，研究员，博士生导师，中国科学院动物所进化与群体基因组学研究组组长。中组部第14批青年千人入选者。2002年毕业于中国科学技术大学生物系，先后在2004和2008年从美国康奈尔大学和加州大学伯克利分校取得生物统计的硕士和群体遗传学博士。2009年6月回到中国科学院北京基因组研究所工作（任副研究员）。2013年9月到2018年6月，在新加坡基因组研究所工作(PI)。2018.6 到中国科学院动物研究所工作，主要从事群体遗传学，细胞的种群遗传学以及癌症基因组学，分子进化等研究方向上的研究。

研究领域：

群体遗传学，细胞群体遗传学，肿瘤基因组学，分子进化，基因组学，计算生物学。

研究方向：

1. 检测适应性进化的方法学 在分子进化研究里，如何在大规模重测序序列(n>1000)的基础上检测适应性进化是领域面临的一个重要的科学问题。常见的密码子模型对于小规模的数据(n<100)有了比较好的模型方法，如何在大规模的时间序列的数据上检测适应性进化成为领域的一个难点。从2002年开始，我们一直致力于发展一个基于随机取样的统计学模型（Nielsen 2002），能对适应性进化的动态规律做系统的检测和描绘(Zhai et al 2007, Chen et al 2016 and 2019)。 2. 细胞群体遗传学和肿瘤基因组学 细胞群体遗传学是一个新兴的交叉学科。它以多细胞物种里的细胞为研究对象，研究细胞群体进化的动态规律。从2009年开始，我们以肝癌和肺癌细胞群体为研究对象，研究细胞群体的异质性和进化规律 (Tao et al 2009, Hu et al 2013, Zhai et al 2017, Nahar*, Zhai* and Zhang* et al 2018)，阐述适应性进化对细胞群体进化以及疾病发展的推动作用。这个研究方向既有面向进化生物学的基础研究，又有面向临床科学问题的转化研究。 3.面向自然物种的群体遗传学 从研究生开始，我一直关注包括人在内的自然种群的演化规律，特别是对物种演化历史以及适应性进化特别感兴趣。 这个研究方向涉猎了人（例如尼安德特人的起源进化Green et al 2010）, 驯化物种（例如家犬 Wang*, Zhai* et al 2013, Wang*, Zhai*, Yang* and Wang* et al 2016）。在动物所的研究，我们将探索新的模式生物体系，继续拓展群体遗传学的研究。

社会任职：

获奖及荣誉：

2010年，AAAS Newcomb Cleveland Prize (Joint work on the Neanderthal project)2012年，中国科学院青年创新促进会2017年，Sanofi-Cell Research outstanding paper award of 2016 (joint work on dog evolution)中组部青年千人计划 2018-2020

承担科研项目情况：

国家自然科学基金面上项目， 用进化基因组学的手段探究癌症的空间异质性的分布和演化, 2020.1-2013.12， 在研，主持

代表论著：

Xu M*, Yao Y*, Chen H*, Zhang S*, et al Zhai W#, Zeng YX#, Liu J#. Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma., Nat Genet. 2019 Jul;51(7):1131-1136. (co-corresponding author).Chen H, Alvarez JJS, Ng SH, Nielsen R, Zhai W. Passage adaptation correlates with the reduced efficacy of the influenza vaccine. Clinical Infectious Disease 2019 Sep 13;69(7):1198-1204.Yang H, Lu B, Lai L, Lim A Alvarez J, Zhai W, PSiTE: a Phylogeny guided Simulator for Tumor Evolution, Bioinformatics, 2019, Sep 1;35(17):3148-3150.Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW, Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer, J Clin Oncol. 2019 Jan 24:JCO1800177.Liu Y, Fu Y, Wang Q, Li M, Zhou Z, Dabbagh D, Fu C, Zhang H, Li S, Zhang T, Gong J, Kong X, Zhai W, Su J, Sun J, Zhang Y, Yu XF, Shao Z, Zhou F, Wu Y, Tan X. Proteomic profiling of HIV-1 infection of human CD4+ T cells identifies PSGL-1 as an HIV restriction factor. Nat Microbiol. 2019 Mar 4.Nahar R*, Zhai W*, Zhang T*, Takano A, Khng AJ, Lee YY, Liu X, Lim CH, Koh TPT, Aung ZW, Lim TKH, Veer avalli L, Yuan J, Teo ASM, Chan CX, Poh HM, Chua IML, Liew AA, Lau DPX, Kwang XL, Toh CK, Lim WT, Lim B, Tam WL, Tan EH, Hillmer AM#, Tan DSW# 'Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing.' Nat Commun 2018 Jan 15 ; 9(1) : 216 (* Equal contribution)Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q 'Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy.' Gut 2018 Mar 30Yang H, Wang G, Wang M, Ma Y, Yin T, Fan R, Wu H, Zhong L, Irwin DM, Zhai W#, Zhang Y# 'The origin of chow chows in the light of the East Asian breeds.' BMC Genomics 2017 Feb 16 ; 18(1) : 174 (# Co-corresponding)Zhai W*,#, Lim TK*, Zhang T*, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS#, Chow PK# 'The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma.' Nat Commun 2017 Feb 27 ; 8 : 4565 (* Joint first, # Corresponding authors)Liu YH, Wang L, Xu T, Guo X, Li Y, Yin TT, Yang HC, Yang H, Adeola AC, J Sanke O, O Otecko N, Wang M, Ma Y, S Charles O, S Sinding MH, Gopalakrishnan S, Samaniego JA, Hansen AJ, Fernandes C, Gaubert P, Budd J, M Dawuda P, Rueness EK, Jiang L, Zhai W, Gilbert MTP, Peng MS, Qi X, Wang GD, Zhang YP 'Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.' Mol Biol Evol 2017 Oct 10Tan WL, Jain A, Takano A, Newell EW, Iyer NG, Lim WT, Tan EH, Zhai W, Hillmer AM, Tam WL, Tan DS 'Novel therapeutic targets on the horizon for lung cancer.' Lancet Oncol 2016 Aug ; 17(8) : e347-62Wu Z, Periaswamy B, Sahin O, Yaeger M, Plummer P, Zhai W, Shen Z, Dai L, Chen SL, Zhang Q 'Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni.' Proc Natl Acad Sci U S A 2016 Sep 20 ; 113(38) : 10690-5 Epub 2016 Sep 6Chen H, Deng Q, Ng SH, Lee RT, Maurer-Stroh S, Zhai W 'Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution.' Mol Biol Evol 2016 Sep 7 Epub 2016 Sep 7Wang GD*, Zhai W*, Yang HC*, Wang L*, Zhong L, Liu YH, Fan RX, Yin TT, Zhu CL, Poyarko v AD, Irwin DM, Hytonen MK, Lohi H, Wu CI, Savolainen P#, Zhang YP# 'Out of southern East Asia: the natural history of domestic dogs across the world.' Cell Res 2015 Dec 15 (* Equal contribution, Cover story)Wang GD, Fan RX, Zhai W, Liu F, Wang L, Zhong L, Wu H, Yang HC, Wu SF, Zhu CL, Li Y, Gao Y, Ge RL, Wu CI, Zhang YP 'Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau.' Genome Biol Evol 2014 Aug ; 6(8) : 2122-8Hu Z, Fu YX, Greenberg AJ, Wu CI#, Zhai W# 'Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis.' PLoS Genet 2013 ; 9(2) : e1003326 Epub 2013 Feb 28 (# co-corresponding author)Wang GD*, Zhai W*, Yang HC, Fan RX, Cao X, Zhong L, Wang L, Liu F, Wu H, Cheng LG, Poyarkov AD, Poyarkov NA, Tang SS, Zhao WM, Gao Y, Lv XM, Irwin DM, Savolainen P, Wu CI#, Zhang YP# 'The genomics of selection in dogs and the parallel evolution between dogs and humans.' Nat Commun 2013 ; 4 : 1860 (* joint first author)Chong Z*, Zhai W*, Li C, Gao M, Gong Q, Ruan J, Li J, Jiang L, Lv X, Hungate E, Wu CI# 'The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster.' Mol Biol Evol 2013 Dec ; 30(12) : 2699-708 Epub 2013 Sep 26 (* joint first author)Ruan J, Jiang L, Chong Z, Gong Q, Li H, Li C, Tao Y, Zheng C, Zhai W, Turissini D, Cannon CH, Lu X, Wu CI 'Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology.' BMC Genomics 2013 ; 14 : 711 Epub 2013 Oct 17Zhai W, Nielsen R, Goldman N, Yang Z 'Looking for Darwin in genomic sequences--validity and success of statistical methods.' Mol Biol Evol 2012 Oct ; 29(10) : 2889-93 Epub 2012 Apr 3Sun M, Gao L, Liu Y, Zhao Y, Wang X, Pan Y, Ning T, Cai H, Yang H, Zhai W#, Ke Y #'Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.' PLoS One 2012 ; 7(5) : e36577 Epub 2012 May 4 (# co-corresponding author)He Z*, Zhai W*, Wen H*, Tang T, Wang Y, Lu X, Greenberg AJ, Hudson RR, Wu CI#, Shi S# 'Two evolutionary histories in the genome of rice: the roles of domestication genes.' PLoS Genet 2011 Jun ; 7(6) : e1002100 Epub 2011 Jun 9 (* joint first author)Tao Y*, Ruan J*, Yeh SH*, Lu X*, Wang Y*, Zhai W*, Cai J*, Ling S, Gong Q, Chong Z, Qu Z, Li Q, Liu J, Yang J, Zheng C, Zeng C, Wang HY, Zhang J, Wang SH, Hao L, Dong L, Li W, Sun M, Zou W, Yu C, Li C, Liu G, Jiang L, Xu J, Huang H, Li C, Mi S, Zhang B, Chen B, Zhao W, Hu S, Zhuang SM, Shen Y, Shi S, Brown C, White KP, Chen DS#, Chen PJ#, Wu CI# 'Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.' Proc Natl Acad Sci U S A 2011 Jul 19 ; 108(29) : 12042-7 Epub 2011 Jul 5 (* joint first author)Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, Albrechtsen A, Skotte L, Lindgreen S, Metspalu M, Jombart T, Kivisild T, Zhai W, Eriksson A, Manica A, Orlando L, De La Vega FM, Tridico S, Metspalu E, Nielsen K, ávila-Arcos MC, Moreno-Mayar JV, Muller C, Dortch J, Gilbert MT, Lund O, Wesolowska A, Karmin M, Weinert LA, Wang B, Li J, Tai S, Xiao F, Hanihara T, van Driem G, Jha AR, Ricaut FX, de Knijff P, Migliano AB, Gallego Romero I, Kristiansen K, Lambert DM, Brunak S, Forster P, Brinkmann B, Nehlich O, Bunce M, Richards M, Gupta R, Bustamante CD, Krogh A, Foley RA, Lahr MM, Balloux F, Sicheritz-Pontén T, Villems R, Nielsen R, Wang J, Willerslev E 'An Aboriginal Australian genome reveals separate human dispersals into Asia.' Science 2011 Oct 7 ; 334(6052) : 94-8 Epub 2011 Sep 22Green RE*, Krause J*, Briggs AW*, Maricic T*, Stenzel U*, Kircher M*, Patterson N*, Li H, Zhai W, Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T, Alkan C, Prüfer K, Meyer M, Burbano HA, Good JM, Schultz R, Aximu-Petri A, Butthof A, Hober B, Hoffner B, Siegemund M, Weihmann A, Nusbaum C, Lander ES, Russ C, Novod N, Affourtit J, Egholm M, Verna C, Rudan P, Brajkovic D, Kucan Z, Gusic I, Doronichev VB, Golovanova LV, Lalueza-Fox C, de la Rasilla M, Fortea J, Rosas A, Schmitz RW, Johnson PL, Eichler EE, Falush D, Birney E, Mullikin JC, Slatkin M, Nielsen R, Kelso J, Lachmann M, Reich D, Paabo S 'A draft sequence of the Neandertal genome.' Science 2010 May 7 ; 328(5979) : 710-22Zhai W, Nielsen R, Slatkin M 'An investigation of the statistical power of neutrality tests based on comparative and population genetic data.' Mol Biol Evol 2009 Feb ; 26(2) : 273-83 Epub 2008 Oct 14Zhai W, Slatkin M, Nielsen R 'Exploring variation in the d(N)/d(S) ratio among sites and lineages using mutational mappings: applications to the influenza virus.' J Mol Evol 2007 Sep ; 65(3) : 340-8 Epub 2007 Sep 11Zhai W, Todd MJ, Nielsen R 'Is haplotype block identification useful for association mapping studies?' Genet Epidemiol 2004 Jul ; 27(1) : 80-3

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