- 滕兆乾
- 研究员
- 北京市海淀区北四环西路25-1号
| 姓 名： | 滕兆乾 |
|---|---|
| 学 科： | 发育生物学 |
| 电话/传真： | +86-10-82619699 / |
| 电子邮件： | tengzq@ioz.ac.cn；teng.zhaoqian@gmail.com |
| 通讯地址： | 北京市海淀区北四环西路25-1号 中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100190 |
| 更多信息： | 干细胞与脑损伤修复研究组 |
简历介绍：
滕兆乾，博士，研究员，博士生导师，干细胞与脑损伤修复研究组组长。 2005年博士毕业于中国科学院动物研究所，先后在中国农业大学、美国新墨西哥大学医学院、路易斯安那州立大学健康科学中心以及约翰霍普金斯大学医学院做博士后与Research Associate，2015年获得中国科学院“百人计划”资助。主要从事神经发生、脑损伤与神经退行性疾病方面的研究，研究成果发表在Cell、 Cell Stem Cell、Stem Cell Reports、The Neuroscientist、Stem Cells、Journal of Neuroscience、Frontiers in Molecular Neuroscience、Journal of Cerebral Blood Flow and Metabolism等国际学术期刊上。
研究领域：
研究工作主要集中在创伤性脑病的发病机理、神经发生与胶质发生的分子调控、以及干细胞在脑损伤修复中的应用研究。研究组的主要研究方向包括：（1）脑损伤后，大脑内环境变化对神经发生、胶质发生与神经再生影响的分子机理；（2）慢性创伤性脑病的分子致病机制；（3）功能性小胶质细胞与星形胶质细胞的定向分化；（4）探索通过干细胞移植和改善神经再生与可塑性内环境而实现脑损伤修复的有效途径。
社会任职：
获奖及荣誉：
承担科研项目情况：
1. 2015-2017 中国科学院“百人计划”，主持，在研 2. 2016-2019 国家自然科学基金面上项目，主持，在研
代表论著：
Pei-Pei Liu, Gang-Bin Tang, Ya-Jie Xu, Yu-Qiang Zeng, Shuang-Feng Zhang, Hong-Zhen Du, Zhao-Qian Teng*, Chang-Mei Liu*. MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells. Stem Cell Reports. 2017, 9(1):190-202. (*Co-correspondence author)Gang-Bin Tang, Yu-Qiang Zeng, Pei-Pei Liu, Ting-Wei Mi, Shuang-Feng Zhang, Shang-Kun Dai, Qing-Yuan Tang, Yang Lin, Ya-Jie Xu, Hai-Liang Yan, Hong-Zhen Du, Zhao-Qian Teng*, Feng-Quan Zhou*, Chang-Mei Liu**. The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice. Front. Mol. Neurosci. 2017, 10:267. doi: 10.3389/fnmol.2017.00267 (*Co-correspondence author)Pei-Pei Liu, Ya-Jie Xu, Zhao-Qian Teng*, Chang-Mei Liu*. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. The Neuroscientist 2017, doi: 10.1177/1073858417747839. (In press)Ping Li, Zhao-Qian Teng, Chang-Mei Liu*. Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury. Neural Plasticity. 2016: 1279051.Jian Zhang, Zhao-Qian Teng, Yunping Song, Mei Hu, Chu Chen. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. J Cereb Blood Flow Metab. 2015 Mar;35(3): 443-453.Jian Zhang, Mei Hu, Zhao-Qian Teng, Yunping Song, Chu Chen. Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease. J Neurosci. 2014 Nov 5;34(45):14919-14933.Rongqing Chen*, Jian Zhang*, Ni Fan*, Zhao-Qian Teng*, Yan Wu*, Hongwei Yang, YaPing Tang, Hao Sun, Yunping Song, Chu Chen.Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling. Cell, 2013, 155 (5), 1154-1165. (*Co-first author)Changmei Liu, Zhao-Qian Teng, Andrea L McQuate, Emily M Jobe, Christa C Christ, Sergei J von Hoyningen-Huene, Marie D Reyes, Eric D Polich, Yina Xing, Yue Li, Weixiang Guo, Xinyu Zhao. An Epigenetic Feedback Regulatory Loop Involving MicroRNA195 and MBD1 Governs Neural Stem Cell Differentiation. PLoS ONE, 2013, 8 (1): e51436. doi:10.1371/journal.pone.0051436.Rongqing Chen, Jian Zhang, Yan Wu, Dongqing Wang, Guoping Feng, Ya-Ping Tang, Zhao-Qian Teng, Chu Chen. Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease. Cell Reports, 2012, 2 (5): 1329-1339.Manavendra Pathania, Juan Torres-Reveron, Lily Yan, Tomoki Kimura, Tiffany V Lin, Valerie Gordon, Zhao-Qian Teng, Xinyu Zhao, Tudor A Fulga, David Van Vactor, Angélique Bordey. miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons. PLoS ONE, 2012, 7 (5): e38174. doi:10.1371/journal.pone.0038174.Weixiang Guo, Li Zhang, Devin M. Christopher, Zhao-Qian Teng, Sarah R. Fausett, Changmei Liu, Olivia L. George, John Klingensmith, Peng Jin, Xinyu Zhao. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression. Neuron, 2011, 70: 924-938.Changmei Liu*, Zhao-Qian Teng*, Nicholas J. Santistevan, Keith E. Szulwach, Weixiang Guo, Peng Jin, Xinyu Zhao. Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation. Cell Stem Cell, 2010, 6: 433-444. (*Co-first author)Richard D. Smrt, Keith E. Szulwach, Rebecca L. Pfeiffer, Xuekun Li, Weixiang Guo, Manavendra Pathania, Zhao-Qian Teng, Yuping Luo, Junmin Peng, Angelique Bordey, Peng Jin, Xinyu Zhao. MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1. Stem Cells, 2010, 28:1060-1070.
写给考生的话：
