何顺民

中国科学院生物物理研究所

浏览次数

60

收藏次数

0

接洽次数

0

  • 何顺民
  • 研究员

何顺民 博士 研究员 博士生导师

中国科学院生物物理所,健康大数据研究中心,常务副主任,首席技术专家

中国科学院大学, 教授

研究方向:生物信息、非编码和表观遗传

北京市朝阳区大屯路15号,邮编100101

个人网页:http://people.ucas.edu.cn/~heshunmin

邮箱:heshunmin(AT)ibp.ac.cn

电话(Tel):+86-010-64887032

英文版个人网页

简历 & 研究组工作摘要

1997 - 2001 南京理工大学,电子工程专业,学士。

2001 - 2004 北京NEC电子有限公司,软件工程师。

2004 - 2009 中国科学院生物物理研究所,生物信息学,硕博连读,博士。

2009 - 2017 中国科学院动物研究所;先后担任副研究员,创新研究员岗位

研究方向:生物信息学、组学大数据整合分析和精准医学。

2010 - 2011 哈佛大学Dana-farber癌症研究所&哈佛大学公共卫生学院,生物统计系,博士后。

研究方向:癌症和表观遗传学。

2016/04 - 2016/07 美国加州大学圣地亚哥分校,细胞与分子医学系,访问学者。

2017 - 至今 中国科学院生物物理研究所,研究员。

健康大数据研究中心,常务副主任,首席技术专家。

中国科学院大学,教授。

研究方向:生物信息、非编码和表观遗传

生物信息方面,主要围绕高通量组学数据的分析和处理,开发相关的算法、软件和数据库;围绕全基因组测序数据的变异位点分析和解读,尤其是针对基因组中97%的非编码区域的变异位点的解读;围绕多组学数据的整合分析等。

非编码方面,主要研究piRNA、microRNA和lncRNA的调控机制和调控网络。

表观遗传方面,主要研究DNA的6mA甲基化修饰的功能和作用方式。

目前工作主要集中在三个方面:

1. 基于大规模人群队列全基因组数据的大数据多组学整合分析平台建设。

2. 基于单细胞多组学的肿瘤发生、发展、转移和临床应用研究。

3. 基于非编码调控区变异分析解读的基因组学数据和临床信息的整合和关联分析。

代表性论文:((#第一/并列第一作者, *通讯/共同通讯作者))

一共发表SCI论文30余篇,更多的信息可以参考:http://people.ucas.edu.cn/~heshunmin

1. Xueye Teng#, Xiaomin Chen#, Hua Xue#, Yiheng Tang, Peng Zhang, Quan Kang, Yajing Hao, Runsheng Chen*, Yi Zhao*, Shunmin He*. (2019). NPInter v4.0: An integrated database of ncRNA interactions. Nucleic Acids Res. DOI: https://doi.org/10.1093/nar/gkz969

2. Shunmin He#, Guoqiang Zhang#, Jiajia Wang#, Yaji Gao#, Ruidi sun, Zhijie Cao, Zhenping Chen, Xiudeng Zheng, Jiao Yuan, Yuewan Luo, Xiaona Wang, Wenxin Zhang, Peng Zhang, Yi Zhao, Chuan He, Yi Tao*, Qinmiao Sun*, Dahua Chen*. (2019). 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nature Communication. 10(1). 2219. DOI: https://doi.org/10.1038/s41467-019-10202-3

3. The RNAcentral Consortium. (2019). RNAcentral: a hub of information for non-coding RNA sequences. Nucleic Acids Res. DOI: https://doi.org/10.1093/nar/gky1034

4. Jiajia Wang#, Peng Zhang#, Yiping Lu#, Yanyan Li, Yu Zheng, Yunchao Kan, Runsheng Chen*, Shunmin He*. (2019). piRBase: a comprehensive database of piRNA sequences. Nucleic Acids Res. DOI: https://doi.org/10.1093/nar/gky1043

5. Liang Chen#, Jia-Yu Chen#, Yi-Jou Huang#, Ying Gu, Jinsong Qiu, Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, Yu Zhou, Omar Abdel-Wahab, Dong-Er Zhang*, Xiang-Dong Fu*. (2018). The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Molecular Cell. 69(3), 412-425 DOI: https://doi.org/10.1016/j.molcel.2017.12.029

6. Xiaowei Chen, Yajing Hao, Ya Cui, Zhen Fan, Shunmin He, Jianjun Luo, Runsheng Chen. (2017). LncVar: a database of genetic variation associated with long non-coding genes. Bioinformatics. 33(1), 112-118 DOI: https://doi.org/10.1093/bioinformatics/btw581

7. Jiao Yuan#, Peng Zhang#, Ya Cui, Jiajia Wang, Geir Skogerbo, Da-Wei Huang, Runsheng Chen*, Shunmin He*. (2016). Computational identification of piRNA targets on mouse mRNAs. Bioinformatics. 32,1170-1177 DOI: https://doi.org/10.1093/bioinformatics/btv729

8. Guoqiang Zhang#, Hua Huang#, Di Liu#, Ying Cheng, Xiaoling Liu, Wenxin Zhang, Ruichuan Yin, Dapeng Zhang, Peng Zhang, Jianzhao Liu, Chaoyi Li, Baodong Liu, Yuewan Luo, Yuanxiang Zhu, Ning Zhang, Shunmin He, Chuan He, Hailin Wang*, Dahua Chen*. (2015). N(6)-methyladenine DNA modification in Drosophila. Cell. 161(4): 893-906. DOI: https://doi.org/10.1016/j.cell.2015.04.018

9. Peng Zhang#, Jun-Yan Kang#, Lan-Tao Gou#, Jiajia Wang, Yuanchao Xue, Geir Skogerboe, Peng Dai, Da-Wei Huang, Runsheng Chen, Xiang-Dong Fu*, Mo-Fang Liu*, Shunmin He*. (2015) MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Research. 25(2): 193-207. DOI: https://doi.org/10.1038/cr.2015.4

10. Peng Zhang#, Xiaohui Si#, Geir Skogerbo, Jiajia Wang, Dongya Cui, Yongxing Li, Xubin Sun, Li Liu, Baofa Sun, Runsheng Chen*, Shunmin He*, Da-wei Huang*. (2014) piRBase: a web resource assisting piRNA functional study. Database(Oxford). 2014, bau110. DOI: https://doi.org/10.1093/database/bau110

11. JiaJia Wang#, Dongya Cui#, Tengfei Xiao#, Xubing Sun, Peng Zhang, Runsheng Chen*, Shunmin He*, Da-Wei Huang*. (2014) The influences of PRG-1 on the expression of small RNAs and mRNAs. BMC Genomics. 15:321. DOI: https://doi.org/10.1186/1471-2164-15-321

12. Jin-Hua Xiao#, Zhen Yue#, Ling-Yi Jia#, Xin-Hua Yang#, Li-Hua Niu#, Zhuo Wang#, Peng Zhang#, Bao-Fa Sun, Shunmin He,…James M Cook*, JunWang* and Da-Wei Huang*. (2013). Obligate Mutualism within a Host Drives the Extreme Specialization of a Fig Wasp Genome. Genome Biology. 14, no. 12: R141. DOI: https://doi.org/10.1186/gb-2013-14-12-r141

13. Li Liu#, Xiaowei Chen#, Geir Skogerb?, Peng Zhang, Runsheng Chen*, Shunmin He*, Da-wei Huang*. (2012). The human microbiome: A hot spot of microbial horizontal gene transfer. Genomics. 100(5):265-270. DOI: https://doi.org/10.1016/j.ygeno.2012.07.012

14. Dongsheng Yan#, Dandan He#, Shunmin He#, Xiaoyan Chen, Zhen Fan and Runsheng Chen. (2011). Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. PLoS One. 6(7): e21652. DOI: https://doi.org/10.1371/journal.pone.0021652

15. Shunmin He#, Hua Su#, Changning Liu#, Geir Skogerbo, Housheng He, Dandan He, Xiaopeng Zhu, Tao Liu, Yi Zhao*, Runsheng Chen* (2008). MicroRNA-encoding long non-coding RNAs. BMC Genomics. vol. 9 pp. 236; DOI: https://doi.org/10.1186/1471-2164-9-236

16. Yi Zhao#, Shunmin He#, Changning Liu#, Songwei Ru, Haitao Zhao, Zhen Yang, Pengcheng Yang, Xiongyin Yuan, Shiwei Sun, Dongbo Bu, Jiefu Huang, Geir Skogerbo*, Runsheng Chen*. (2008). MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control. Trends Genet. vol. 24 (7) pp. 323-7; DOI: https://doi.org/10.1016/j.tig.2008.04.004

17. Shunmin He#, Zhen Yang#, Geir Skogerbo, Fei Ren, Hongliang Cui, Haitao Zhao, Runsheng Chen, Yi Zhao. (2008). The properties and functions of virus encoded microRNA, siRNA, and other small noncoding RNAs. Critical Revs. in Microbiology. vol. 34 (3-4) pp. 175-88. DOI: https://doi.org/10.1080/10408410802482008

18. Shunmin He#, Changning Liu#, Geir Skogerbo, Haitao Zhao, Jie Wang, Tao Liu, Baoyan Bai, Yi Zhao*, Runsheng Chen*. (2008). NONCODE v2.0: decoding the non-coding. Nucleic Acids Res. DOI: https://doi.org/10.1093/nar/gkm1011

19. 吴涛,何顺民,陈润生(2007). 非编码基因的功能、调控与双色网络.《2007科学发展报告》

资料来源:何顺民研究员,2019-11-26网页更新