黄韶辉

中国科学院生物物理研究所

浏览次数

52

收藏次数

0

接洽次数

0

  • 黄韶辉
  • 研究员

黄韶辉 博士 研究员

中国科学院“杰出引进技术人才”(技术百人)

中国科学院生物物理所,交叉科学所重点实验室,转化研究核心组研究组长

研究方向:

光学仪器研发和产业化,细胞器生物生成的分子机制

电子邮件(E-mail):shaohuih@ibp.ac.cn

电话(Tel):86-10-64887732

地址:北京市朝阳区大屯路15号3号楼3302室

邮政编码 100101

英文版个人网页

简历 & 研究组工作摘要

1989-1991 中山大学生物化学系,本科生

1991-1993 堪萨斯大学分子生命科学系,生物化学学士

1993-1998 堪萨斯大学分子生命科学系,生物化学、细胞和分子生物学博士

1998-2002 康奈尔大学应用和工程物理系,博士后

2002-2009 马萨诸塞大学医学院分子医药系,研究助理教授

2009-2013 宾夕法尼亚大学医学院环境医学研究所,研究员

2009-2013 宾夕法尼亚大学医学院环境医学研究所,研究员

2009-2013 宾夕法尼亚大学医学院环境医学研究所肺成像和形态学中心,主任

2013-至今 中国科学院生物物理研究所,研究员、课题组长

主要研究方向:

一、光学仪器研发和产业化

课题组开发了目前全球市场上唯一一款荧光相关光谱POCT(Point-of-care Testing)分析仪CorTectorTMSX100。在此基础上与广东中山翠亨新区合作实施“荧光相关光谱仪和其他光学仪器的产业化项目”。该项目致力于科研、医疗仪器及相关试剂的研发、制造和销售。此外,课题组还搭建了具世界领先水平的单分子研究平台“全参数荧光检测光谱仪-原子力显微镜整合系统”,并应用于生物医学领域的前沿研究。

二、生物材料、纳米化学/医学及细胞器生物生成的分子机制

课题组开展新型靶向药物、功能高分子材料及药物智能递送系统的研究。开发光敏感纳米材料和基于纳米技术的重大疾病诊疗一体化系统。应用先进光学成像、光谱分析技术对纳米材料在细胞内转运机制进行定量分析。开展与肺纤维化疾病相关的肺泡II型细胞中板层小体(Lamellar Body)巨大化病变的分子机制研究。

三、脑功能研究及相关技术开发

课题组从事脑功能研究,开发用于医学和神经科学研究的光电一体脑功能检测技术和仪器。

研究团队/课题组成员:

在职研究人员:

梁艳琴博士副研究员

肖茜博士副研究员

天津大学化工学院博士

中国科学院生物物理研究所博士

北京大学药学院博士后

德国鲁尔大学&加拿大女王大学博士后

团队职责:化学与生物学分组组长

团队职责:脑功能研究及仪器研发分组组长

研究方向:生物材料、纳米化学/医学及新光学成像技术从单分子层面上分析纳米材料体内转运

研究方向:光学仪器在医学和神经科学方面的应用

项目及成果:主持2项国家级项目,正式发表SCI论文表10多篇,申请中国发明专利2项。

项目及成果:主持1项国家级项目,正式发表多篇SCI论文,申请中国发明专利1项。

E-mail:yqinliang@ibp.ac.cn

E-mail:qianxiao@ibp.ac.cn

王柱楼硕士工程师

吴岩硕士科研助理(兼)

天津大学精密仪器与光电子工程学院硕士

北京农学院食品工程学院硕士

研究方向:光学仪器研发和产业化

E-mail:wuy@ibp.ac.cn

E-mail:wangzhulou@126.com

在读研究生:

朱亚珂

刘琳

康宁

孟权

薛威

2015级硕士研究生

2015级硕士研究生

2015级硕士研究生

2017级硕士研究生

2017级硕士研究生

代表性论文

1. Liang Y., Li S., Wang X., Zhang Y., Sun Y., Wang Y., Wang X., He B., Dai W., Zhang H., Wang X., Zhang Q., A comparative study of the antitumor efficacy of responsive prodrug-nanosystem consisting of amphiphilic small-molecule targeting peptide-doxorubicin conjugates with different linkers, J Control Release, 2018, Accept.

2. Liang Y., Li S., Wang X., He B., He B., Dai W., Zhang H., Wang X., Wang Y., Zhou D., ZhangQ., A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid, Theranostics, 2017, 7(13): 3306-3318.

3. Yang Y., Wang Q., Wang S.R., Wang Y.*, Xiao Q.*, Representation of time interval entrained by periodic stimuli in the visual thalamus of pigeons, Elife, 2017, 6: e27995.

4. Liang Y.*, Dong C., Zhang J., Deng L., Dong A., A reconstituted thermosensitive hydrogel system based on paclitaxel-loaded amphiphilic copolymer nanoparticles and antitumor efficacy, Drug Dev Ind Pharm,2017, 43(6): 972-979.

5. Xu L., Ren Z., Chow F.E., Tsai R., Liu T., Rizzolio F., Boffo S., Xu Y., Huang S., Lippa C.F., Gong Y., Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast, 2017, 2017: 3270725.

6. Stacho M., Str?ckens F., Xiao Q.*, Güntürkün O., Functional organization of telencephalic visual association fields in pigeons, Behav Brain Res, 2016,303: 93-102.

7. Liang Y., Xiao L., Zhai Y., Xie C., Deng L., Dong A., Preparation and Characterization of Biodegradable Poly(sebacic anhydride) Chain Extended by Glycol as Drug Carrier, J Appl Polym Sci, 2013, 127(5): 3948-3953.

8. Xiao Q.*, Frost B.J., Motion parallax processing in pigeon (Columba livia) pretectal neurons, Eur J neurosci, 2013, 37(7): 1103-1111.

9. Roszell B.R., Tao J.Q., Yu K.J., Gao L., Huang S., Ning Y., Feinstein S.I., Vite C.H., Bates S.R., Pulmonary Abnormalities in Animal Models Due to Niemann-Pick Type C1 (NPC1) or C2 (NPC2) Disease, PLoS One, 2013, 8(7): e67084.

10. Liang Y., Qiao Y., Guo S., Wang L., Zhai Y., Xie C., Hu R., Deng L., Dong A., Investigation on injectable, thermally and physically gelable poly(ethylene glycol)/poly(octadecanedioic anhydride) amphiphilic triblock copolymer nanoparticles, J Biomater Sci Polym Ed, 2012, 23(1-4): 465-482.

11. Rahaman H., Zhou S., Dodia C., Feinstein S.I., Huang S., Speicher D.W., Fisher A.B., Increased phospholipase A(2) activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein, Biochemistry, 2012, 51(27): 5521-5530.

12. Yu M., Huang S., Yu K.J., Clyne A.M., Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture, Int J Mol Sci, 2012, 13(5): 5554-5570.

13. Feng S., Knodler A., Zhang J., Zhang X., Hong Y., Huang S., Peranen J., Guo W., A Rab8 GEF-effector interaction network regulates primary ciliogenesis, J Biol Chem, 2012, 287(19): 15602-15609.

14. Roszell B.R., Tao J.Q., Yu K.J., Huang S., Bates S.R., Characterization of the Niemann-Pick type C pathway in the lamellar body cholesterol content of alveolar type II cells, Am J Physiol Lung Cell Mol Physiol, 2012, 302(9): L919-932.

15. Zhang L., Yu K., Robert K.W., DeBolt K.M., Hong N., Tao J.-Q., Fukuda M., Fisher A.B., Huang, S.*, Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells, Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L461-477.

16. Liang Y., Deng L., Chen C., Zhang J., Zhou R., Li X., Hu R., Dong A., Preparation and properties of thermoreversible hydrogels based on methoxy poly(ethylene glycol)-grafted chitosan nanoparticles for drug delivery systems, Carbohydr Polym, 2011, 83(4): 1828-1833.

17. Liang Y., Xiao L., Li Y., Zhai Y., Xie C., Deng L., Dong A., Poly(ester anhydride)/mPEG Amphiphilic Block Co-polymer Nanoparticles as Delivery Devices for Paclitaxel, J Biomater Sci Polym Ed, 2011, 22(4-6): 701-715.

18. Thom S.R., Bhopale V.M., Yang M., Bogush M., Huang S., Milovanova T.N., Neutrophil β2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with s-nitrosylated actin, J Biol Chem, 2011, 286(37): 32854-32865.

19. Thom S.R., Yang M., Bhopale V.M., Huang S., Milovanova T.N., Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries, J Appl Physiol, 2011, 110(2): 340-351.

20. Shuvaev V.V., Han J., Yu K.J., Huang S., Hawkins B.J., Madesh M., Nakada M., Muzykantov V.R., PECAM-targeted delivery of SOD inhibits endothelial inflammatory response, FASEB J, 2011, 25(1): 348-357.

21. Liang Y., Qiao Y., Guo S., Wang L., Xie C., Zhai Y., Deng L., Dong A., Thermoreversible gelation of poly(ethylene glycol)/poly(ester anhydride) triblock copolymer nanoparticles for injectable drug delivery systems, Soft Matter, 2010, 6(9): 1915-1922.

22. Saito T., Jones C.C., Huang S., Czech M.P., Pilch P.F., The interaction of AKT with APPL1 is required for insulin-stimulated Glut4 translocation, J Biol Chem, 2007, 282(44): 32280-32287.

23.DiNtto J.P., Delprato A., Gabe Lee M.T., Cronin T.C., Huang S., Guilherme A., Czech M.P., Lambright D.G., Structural basis and mechanism of autoregulation in 3-phosphoinositide dependent Arf GTPase exchange factors, Mol Cell, 2007, 28(4): 569-583.

24. Huang S., Czech M.P., The GLUT4 glucose transporter, Cell Metab, 2007, 5(4): 237-252.

25. Huang S., Lifshitz L., Jones C., Bellve K.D., Standley C., Fonseca S., Corvera S., Fogarty K., Czech M.P., Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes, Mol Cell Biol, 2007, 27(9): 3456-3469.

26. Bose A., Guilherme A., Huang S., Hubbard A.C., Lane C.R., Soriano N.A., Czech M.P., The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes, J Biol Chem, 2005, 280(44): 36946-36951.

27. Huang S., Lifshitz L., Patki-Kamath V., Tuft R., Fogarty K., Czech M.P., Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes, Mol Cell Biol, 2004, 24(20): 9102-9123.

28.Hess S.T., Huang S., Heikal A.A., Webb W.W., Biological and Chemical Applications of Fluorescence correlation spectroscopy: a review, Biochemistry, 2002, 41(3): 697-705.

29. Huang S., Heikal A.A., Webb W.W., Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein, Biophys J, 2002, 82(5): 2811-2825.

30. Wenseleers W., Stellacci F., Pond S., Parker T., Mangel T., Halik M., Meyer-Friedrichsen T., Perry J.W., Marder S.R., Heikal A.A., Huang S., Webb, W.W., Two-photon fluorescent labels with enhanced sensitivity for biological imaging, 2000, IEEE (LEOS 2000) 1:330-331.

31. Negash S., Huang S., Squier T.C., Rearrangement of domain elements of the Ca-ATPase in cardiac sarcoplasmic reticulum membranes upon phospholamban phosphorylation, Biochemistry, 1999, 38(25): 8150-8158.

32. Huang S., Squier T.C., Enhanced rotational dynamics of the phosphorylation domain of the Ca-ATPase upon calcium activation, Biochemistry, 1999, 37(51): 18064-18073.

33. Huang S., Negash S., Squier T.C., Erythrosin isocyanate selectively labels lysine464 within an ATP-protectable binding site on the Ca-ATPase in skeletal sarcoplasmic reticulum membranes, Biochemistry, 1998, 37(19): 6949-6957.

资料来源:黄韶辉研究员,2018-02-01网页更新