- 李云海
- 研究员
李云海，博士，研究员，博士生导师 1996年河南大学学士，1999年中国农业科学院硕士，2003年中国科学院遗传与发育生物学研究所博士。2003-2008年英国John Innes Centre博士后。2008年9月任中国科学院遗传与发育生物学研究所研究员，博士生导师； 中国科学院“百人计划”入选者；2015年“国家杰出青年基金”获得者; 2016年入选科技部“中青年科技创新领军人才”； 2017年获得第三批国家“万人计划”领军人才。研究方向:植物种子和器官大小调控的分子机理 植物是如何感知并决定其种子和器官大小是一个重要的发育生物学问题。同时，植物种子和器官大小也是重要的产量性状，因此对其调控机理的研究将为高产育种提供基因资源和理论基础。我们实验室以水稻和拟南芥为研究材料，通过遗传学、细胞生物学、生物化学和生物信息学等手段研究植物种子与器官大小调控的分子机理,为高产育种提供理论基础和基因资源。 1、 双子叶植物种子和器官大小调控的分子机理研究 我们实验室在模式植物拟南芥中克隆了一系列种子和器官大小调控的关键因子；发现了多个种子和器官大小调控的遗传途径；初步建立了几个种子和器官大小调控的分子遗传网络。目前正在解析种子和器官大小关键调控因子作用的分子遗传机制，建立完善的种子和器官大小调控网络。并应用模式植物的研究结果到作物中，提供作物产量和生物量。 2、单子叶植物种子和器官大小调控的分子机理研究 水稻产量主要由粒重、穗粒数和分蘖数等重要农艺性状决定。水稻种子和器官大小是影响水稻产量的关键因素。通过QTL和GWAS分析等从野生稻和地方水稻品种中发掘种子和器官大小调控的关键因子；利用已分离的一系列水稻种子和器官大小的突变体，已克隆一系列种子和器官大小调控的关键基因；在水稻中建立种子和器官大小调控的遗传和分子网络，阐明其作用的分子机理，为高产育种提供基因资源和理论基础。研究组工作人员 段朋根（副研究员）、张保兰（工程师）、张丽敏（助理研究员）博士后和客座研究生招聘信息： 本实验室目前计划招生2名博士后和2名客座研究生，欢迎对植物种子和器官大小调控研究感兴趣的有志青年申请(yhli@genetics.ac.cn)。近期发表的论文 （* 为通讯作者; #共同第一作者）：2019Zupei Liu #, Gang Chen#, Fan Gao, Ran Xu, Na Li, Yueying Zhang, Yunhai Li*.(2019) Transcriptional Repression of the APC/C Activator Genes CCS52A1/A2 by the Mediator Complex Subunit MED16 Controls Endoreduplication and Cell Growth in Arabidopsis.The Plant Cell. Jun 7. doi: 10.1105/tpc.18.00811.Na Li#, Ran Xu#, Yunhai Li*.(2019) Molecular networks of seed size control in plants. Annual Review of Plant Biology. doi: 10.1146/annurev-arplant-050718-095851. (Invited review)Ran Xu#, Na Li#, Yunhai Li*.(2019) Control of grain size by G protein signaling in rice. J Integr Plant Biol. doi: 10.1111/jipb.12769. (Invited review)2018Yuancheng Peng#, Liangliang Chen#, Shengjun Li#, Yueying Zhang, Ran Xu, Zupei Liu, Wuxia Liu, Jingjing Kong, Xiahe Huang, Yingchun Wang, Beijiu Cheng*, Leiying Zheng* and Yunhai Li* (2018) BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis Nature Communications DOI:10.1038/s41467-018-03884-8Shengjun Li#, Ran Xu#, Aixia Li#, Kan Liu, Liqing Gu, Mu Li, Hairui Zhang, Yueying Zhang, Shangshang Zhuang, Quanhui Wang, Gang Gao, Na Li, Chi Zhang, Yunhai Li*, Bin Yu*. (2018) SMA1, a homolog of the splicing factor Prp28, has a multifaceted role in miRNA biogenesis in Arabidopsis SMA1, a homolog of the splicing factor Prp28, has a multifaceted role in miRNA biogenesis in Arabidopsis. Nucleic Acids Research, https://doi.org/10.1093/nar/gky591.Xu R#, Yu H#, Wang J#, Duan P#, Zhang B, Li J, Li Y, Xu J, Lyu J, Li N, Chai T, Li Y*. (2018) A Mitogen-Activated Protein Kinase Phosphatase influences grain size and weight in rice.Plant Journal, 2018 May 18. doi: 10.1111/tpj.13971.Ran Xu#, Penggen Duan,#, Haiyue Yu#, Zhengkui Zhou, Baolan Zhang, Ruci Wang, Jing Li, Guozheng Zhang, Shangshang Zhuang, Jia Lyu, Na Li, Tuanyao Chai, Zhixi Tian, Shanguo Yao and Yunhai Li* (2018) Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice. Molecular Plant, DOI:10.1016/j.molp.2018.04.004Li N#, Liu Z#, Wang Z, Ru L, Gonzalez N, Baekelandt A, Pauwels L, Goossens A, Xu R, Zu Z, Inzé D, Li Y*. (2018) STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana. PLoS Genetics. 2018 Feb 5;14(2):e1007218.Li N, Xu R, Duan P, Li Y*. (2018) Control of grain size in rice.Plant Reprod. 10. doi: 10.1007/s00497-018-0333-6. (Invited review)Baekelandt A, Pauwels L, Wang Z, Li N, De Milde L, Natran A, Vermeersch M, Li Y, Goossens A, Inzé D, Gonzalez N. (2018) Arabidopsis Leaf Flatness Is Regulated by PPD2 and NINJA through Repression of CYCLIN D3Genes.Plant Physiology. 178(1):217-232.2017Huang K#, Wang D#, Duan P#, Zhang B, Xu R, Li N,Li Y*. (2017)WIDE AND THICK GRAIN 1, which encodes an otubain-like protease with deubiquitination activity, influences grain size and shape in rice.Plant Journal. doi: 10.1111/tpj.13613.Duan P#, Xu J#, Zeng D, Zhang B, Geng M, Zhang G, Huang K, Huang L, Xu R, Ge S, Qian Q and Li Y*. (2017) Natural variation in the promoter of GSE5 contributes to grain size diversity in rice. Molecular Plant 10(5):685-694. Dong H#, Dumenil J#, Lu F#, Li N#., Vanhaeren H, Naumann C, Klecker M, Prior R, Smith C, McKenzie N, Saalbach G, Chen C, Xia T, Gonzalez N, Seguela M, Inze D, Dissmeyer N, Li Y*, Bevan M*. (2017) Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Genes & Development 15;31(2):197-208. Wang J, Tang M, Chen S, Zheng X, Mo H, Li S, Wang Z, Zhu K, Ding L, Liu S, Li Y*, Tan X*. (2017) Down-regulation of BnDA1, whose gene locus is associated with the seeds weight, improves the seeds weight and organ size in Brassica napus. Plant Biotechnology Journal doi: 10.1111/pbi.126962016Li, N., Li, Y* (2016) Signaling pathways of seed size control in plants. Current Opinion in Plant Biology 33:23-32. (Invited review)Chen L#., Peng, Y#., Tian, J., Wang, X, Kong, Z, Mao, T, Yuan, M, Li Y* (2016) TCS1, a microtubule-binding protein, interacts with KCBP/ZWICHEL to regulate trichome cell shape in Arabidopsis thaliana. PLoS Genetics doi: 10.1371/journal.pgen.1006266.Xu, Y#., Jin, W#., Li, N., Zhang, W., Liu, C., Li, C*., Li, Y* (2016) UBIQUITIN-SPECIFIC PROTEASE 14 interacts with ULTRAVIOLET-B INSENSITIVE 4 to regulate endoreduplication and cell and organ growth in Arabidopsis. The Plant Cell 28(5):1200-1214.Wang Z., Li N., Jiang S., Gonzalez N., Huang X., Wang Y., Inze D., Li, Y* (2016) SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. Nature Communications doi:10.1038/NCOMMS11192.Fang N, Xu R, Huang L, Zhang B, Duan P, Li N, Luo Y*, Li Y*. (2016)SMALL GRAIN 11 Controls Grain Size, Grain Number and Grain Yield in Rice.Rice 9(1):64.2015Duan, P#., Ni, S#., Wang, J#., Zhang, B#., Xu, R., Wang, Y., Chen, H., Zhu, X*., and Li Y* (2015) Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice. Nature Plantsdoi: 10.1038/nplants.2015.203. (Cover story)Zhang, Y., Du, L., Xu, R., Cui, R., Hao, J., Sun, C., and Li Y* (2015) Transcription factors SOD7/NGAL2 and DPA4/NGAL3 act redundantly to regulate seed size by directly repressing KLU expression in Arabidopsis thaliana. The Plant Cell 27(3):620-32.Peng, Y#., Chen, L#., Lu, Y., Wu, Y., Dumenil, J., Zhu, Z., Bevan, M., and Li Y* (2015)The ubiquitin receptors DA1, DAR1 and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/14 in Arabidopsis. The Plant Cell 27(3):649-62.Liu, S., Hua, L., Dong, S., Chen, H., Zhu, X., Jiang, J., Zhang, F., Li, Y., Fang, X., and Chen F (2015) OsMAPK6, a mitogen-activated protein kinase, influences rice grain size and biomass production.Plant Journal 14. doi: 10.1111/tpj.13025.Zheng, L*#., Shang, L#., Chen, X., Zhang, L., Xia, Y., Smith, C., Bevan, MW., Li, Y., Jing, HC. (2015) TANG1, Encoding a Symplekin_C Domain-Contained Protein, Influences Sugar Responses in Arabidopsis.Plant Physiology 168(3):1000-12.Li, N., and Li, Y., * (2015) Maternal control of seed size in plants. Journal of Experimental Botany 66(4):1087-1097. (Invited review)2014Du, L#., Li, N#., Chen, L., Xu, Y., L, Y., Zhang, Y., Li, C., Li, Y*. (2014) The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis. The Plant Cell 26(2):665-677.Li, N., Li, Y*. (2014) Ubiquitin-mediated control of seed size in plants. Frontiers in Plant Science doi: 10.3389/fpls.2014.00332. (Invited review)Duan, P#., Rao, Y#., Zeng, D#., Yang, Y., Xu, R., Zhang, B., Dong, G., Qian, Q.*, Li, Y*. (2014) SMALL GRAIN 1, which encodes a mitogen-activated protein kinase kinase 4 (MKK4), influences grain size in rice. The Plant Journal 77(4):547-57.Colas des Francs-Small C, Falcon de Longevialle A, Li Y, Lowe E, Tanz S, Smith C, Bevan M, Small I. (2014) THE PPR PROTEINS TANG2 AND OTP439 ARE INVOLVED IN THE SPLICING OF THE MULTIPARTITE nad5 TRANSCRIPT ENCODING A SUBUNIT OF MITOCHONDRIAL COMPLEX I. Plant Physiology pii: pp.114.2446162013Xia T#., Li, N#., Dumenil, J., Li, J., Kamenski, A., Bevan, M., Gao, F., Li, Y*. (2013) The Ubiquitin Receptor DA1 Interacts with the E3 Ubiquitin Ligase DA2 to Regulate Seed and Organ Size in Arabidopsis. The Plant Cell 25(9):3347-59.Peng, Y#., Ma, W#., Chen, L., Yang, L., Li, S., Zhao, H., Zhao, Y., Jin, W., Li, N., Bevan, MW., Li, X., Tong, Y*., Li, Y*. (2013) Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 161(3):1542-56.Peng Y, Chen L, Lu Y, Ma W, Tong Y, Li Y*. (2013) DAR2 acts as an important node connecting cytokinin, auxin, SHY2 and PLT1/2 in root meristem size control.Plant Signal Behav. Mar 21;8(6). doi:pii: e24226.2012Fang, W#., Wang, Z#., Cui, R., Li, J., and Li, Y*. (2012) Maternal control of seed size by EOD3/CYP78A6 in Arabidopsis thaliana. The Plant Journal 70(6):929-39.Li, S#., Liu, Y#., Zheng, L., Chen, L., Li, N., Corke, F., Lu, Y., Fu, X., Zhu, Z., Bevan, M., and Li, Y*. (2012) The plant specific G protein γ subunit AGG3 influences organ size and shape in Arabidopsis thaliana. New Phytologist 194(3):690-703.Li S, Liu W, Zhang X, Liu Y, Li N, Li, Y*. (2012) Roles of the Arabidopsis G protein γ subunit AGG3 and its rice homologs GS3 and DEP1 in seed and organ size control. Plant Signal Behav. 7(10):1357-9Xu, R and Li, Y*. (2012). The Mediator complex subunit 8 regulates organ size in Arabidopsis thaliana. Plant Signal Behav. 7(2):182-3.2011Xu, R and Li, Y*. (2011) Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana. Development 138:4545-4554. 2010以前Li, Y*,Zheng, L., Corke, F., Smith, C., and Bevan, M.W*. (2008) Control of seed and organ size by the DA1 gene family in Arabidopsis thaliana. Genes & Development 22:1331-1336.Li, Y., Smith, C., Corke, F., Zheng, L., Merali, Z., Ryden, P., Derbyshire, P., Waldron, K., and Bevan, M.W*. (2007) Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana. ThePlant Cell 19:2500-2515.Li, Y., Lee, K.K., Walsh, S., Smith, C., Hadingham, S., Sorefan, K., Cawley, G., and Bevan, M.W*. (2006) Establishing glucose- and ABA-regulated transcription networks in Arabidopsis by microarray analysis and promoter classification using a Relevance Vector Machine. Genome Research 16:414-427.Rook F, Hadingham S, Li Y and Bevan MW*. (2006) Sugar and ABA response pathways and the control of gene expression. Plant Cell & Enviroment29 (3):426-434.Li, Y#., Sorefan, K#., Hemmann, G#., and Bevan, M.W*. (2004) Arabidopsis NAP and PIR regulate actin-based cell morphogenesis and multiple developmental processes. Plant Physiology 136:3616-3627.Li, Y#., Qian, Q#., Zhou, Y#., Yan, M., Sun, L., Zhang, M., Fu, Z., Wang, Y., Han, B., Pang, X., Chen, M., and Li, J*. (2003) BRITTLE CULM1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. ThePlant Cell 15:2020-2031.
