刘志勇

中国科学院遗传与发育生物学研究所

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  • 刘志勇
  • 研究员

刘志勇,博士,研究员,博士生导师 1996年和1999年中国农业大学获得硕士和博士学位,1999年至2004年在瑞士ETH Zurich和美国Hawaii Agriculture Research Center进行博士后研究,2004年回国到中国农业大学工作并获得国家杰出青年基金,2016年到中国科学院遗传与发育生物学研究所工作担任课题组长。 刘志勇博士课题组的主要研究方向是小麦基因组学、遗传学和育种,利用遗传学和基因组学手段解析小麦抗病性和重要农艺性状形成的遗传学基础,发掘小麦野生种、地方品种和育成品种中抗病基因和重要农艺性状基因/QTL及其优异等位变异,进行种质创新和新品种培育。主要研究内容: 1.小麦抗病基因发掘、精细定位和图位克隆 小麦锈病(条锈病、叶锈病)、白粉病和叶枯病是严重危害小麦生产的重要病害。课题组收集国内外的小麦野生种、地方品种和育成品种,进行系统的抗病性鉴定和遗传分析,利用分子标记定位种质资源中的抗病基因。利用比较基因组学手段,应用高通量SNP分析和下一代测序手段对抗病基因进行精细定位和图位克隆,旨在解析小麦对重要真菌性病害的抗性遗传和分子机理,研究小麦抗病基因的遗传进化和变异机制,开发抗病基因功能标记应用于小麦分子育种。 2.小麦重要农艺性状基因/QTL定位、精细定位和图位克隆 小麦产量构成因素、株型(株高、叶片形态、茎杆质地等)和抗逆性(根系性状)是影响小麦产量的重要农艺性状。课题组以小麦遗传群体和自然群体为材料,利用高通量SNP分析和下一代测序技术进行遗传作图,对控制重要农艺性状的基因/QTL进行定位、精细定位和图位克隆,应用于小麦产量潜力的遗传改良和分子育种。 3.小麦种质创新和新品种培育 综合利用常规育种和分子育种技术手段,创制和培育适于我国小麦主产区的高产、抗病、抗逆、节水种质资源和新品种。 4.短柄草研究 以短柄草为对象,开展抗大麦条纹花叶病毒(BSMV)基因克隆及其与BSMV互作研究。育成品种: 小麦新品种“农大1108”(豫审麦2012004号)主要育种人(第二完成人) 小麦新品种“农大399”(冀审麦2012004号)主要育种人(第二完成人) 小麦新品种“农大408”(京审麦2010001号)主要育种人(第二完成人) 小麦新品种“农大多系1号”(京审麦2008003号)主要育种人(第二完成人) 小麦新品种“农大413”(京审麦2007003号)主要育种人(第二完成人) 小麦新品种“农大318”(津审麦2006002号)主要育种人(第二完成人)获得奖励: 小麦抗病优质多样化基因资源发掘、创新和利用。2015年度,国家科学技术进步二等奖(第二完成人) 小麦锈病和白粉病多样化抗源发掘、创新和利用。2010年度,教育部科技进步一等奖(第二完成人)主要论文:(*通讯作者)Shengnan Zhai, Zhonghu He, Weie Wen, Hui Jin, Jindong Liu, Yong Zhang, ZhiyongLiu, Xianchun Xia (2016) Genome-wide linkage mapping of flour color?related traits and polyphenol oxidase activity in common wheat. Theor Appl Genet 129:377-394Meiyan Liu, Lei Lei, Carol Powers, ZhiyongLiu, Kimberly G. Campbell, Xianming Chen, Robert L. Bowden, Brett F. Carver, Liuling Yan (2016) TaXA21-A1 on chromosome 5AL is associated with resistance to multiple pests in wheat. Theor Appl Genet 129:345-355Ping Lu, Yong Liang, Delin Li, Zhengzhong Wang, Wenbin Li, Guoxin Wang, Yong Wang, Shenghui Zhou, Qiuhong Wu, Jingzhong Xie, Deyun Zhang, Yongxing Chen, Miaomiao Li, Yan Zhang, Qixin Sun, ChengguiHan, ZhiyongLiu* (2016) Fine genetic mapping of spot blotch resistance gene Sb3 in wheat (Triticumaestivum). Theor Appl Genet 129:577-589Qiuhong Wu, Yongxing Chen, Lin Fu, Shenghui Zhou, Jiaojiao Chen, Xiaojie Zhao, Dong Zhang, Shuhong Ouyang, Zhenzhong Wang, Dan Li, Guoxin Wang, Deyun Zhang, Chengguo Yuan Lixin Wang, Mingshan You, Jun Han, ZhiyongLiu* (2016) QTL mapping of flag leaf traits in common wheat using an integrated high-density SSR and SNP genetic linkage map. Euphytica 208:337-351Ping Lu, Jinxia Qin, Guoxin Wang, Lili Wang, Zhenzhong Wang, Qiuhong Wu, Jingzhong Xie, Yong Liang, Yong Wang, Deyun Zhang, Qixin Sun, ZhiyongLiu* (2015) Comparative fine mapping of the Wax 1 (W1) locus in hexaploid wheat. Theor Appl Genet 128(8):1595-1603Yong Liang, De-Yun Zhang, Shuhong Ouyang, Jingzhong Xie, Qiuhong Wu, Zhenzhong Wang, Yu Cui, Ping Lu, Dong Zhang, Zi-Ji Liu, Jie Zhu, Yong-Xing Chen, Yan Zhang, Ming-Cheng Luo, Jan Dvorak, Naxin Huo,Qixin Sun, Yong-Qiang Gu, ZhiyongLiu* (2015) Dynamic evolution of resistance gene analogs in the orthologous genomic regions of powdery mildew resistance gene MlIW170 in Triticumdicoccoidesand Aegilopstauschii. Theor Appl Genet 128(8):1617-1629Zhenzhong Wang, Hanwen Li, Deyun Zhang, Li Guo, Jiaojiao Chen, Yongxing Chen, Qiuhong Wu, Jingzhong Xie, Yan Zhang, Qixin Sun, Jan Dvorak, Ming-Cheng Luo, ZhiyongLiu* (2015) Genetic and physical mapping of powdery mildew resistance gene MlHLT in Chinese wheat landrace Hulutou. Theor Appl Genet 128:365-373Qiu-Hong Wu, Yong-Xing Chen, Sheng-Hui Zhou, Lin Fu, Jiao-Jiao Chen, Yao Xiao, Dong Zhang, Shu-Hong Ouyang, Xiao-Jie Zhao, Yu Cui, De-Yun Zhang, Yong Liang, Zhen-Zhong Wang, Jing-Zhong Xie, Jin-Xia Qin, Guo-Xin Wang, De-Lin Li, Yin-Lian Huang, Mei-Hua Yu, Ping Lu, Li-Li Wang, Ling Wang, Hao Wang, Chen Dang, Jie Li, Yan Zhang, Hui-Ru Peng, Cheng-Guo Yuan, Ming-Shan You, Qi-Xin Sun, Ji-RuiWang, Li-Xin Wang, Ming-Cheng Luo, Jun Han, Zhi-Yong Liu* (2015) High-density linkage map construction and QTL mapping of grain shape and size in the wheat population Yanda1817 × Beinong6.PloS ONE,10(2): e0118144Dong Zhang, Shuhong Ouyang, Lili Wang, Yu Cui, Qiuhong Wu, Yong Liang, Zhenzhong Wang, Jingzhong Xie, Deyun Zhang, Yong Wang, Yongxing Chen, and ZhiyongLiu* (2015) Comparative genetic mapping revealed powdery mildew resistance gene MlWE4 derived from wild emmer is located in same genomic region of Pm36 and Ml3D232 on chromosome 5BL. Journal of Integrative Agriculture 14:603-609Shuhong Ouyang, Dong Zhang, Jun Han, Xiaojie Zhao, Yu Cui, Wei Song, Naxin Huo, Yong Liang, Jingzhong Xie, Zhenzhong Wang, Qiuhong Wu, Yongxing Chen, Ping Lu, Deyun Zhang, Lili Wang, Hua Sun, TsominYang, Gabriel Keeble-Gagnere, Rudi Appels, Jaroslav Dole?el, Hong-Qing Ling, Mingcheng Luo, Yongqiang Gu, Qixin Sun, ZhiyongLiu* (2014) Fine genetic mapping and toward physical mapping of powdery mildew resistance gene MlIW172 originating from wild emmer (Triticumdicoccoides). PLoS ONE 9(6): e100160.Zhenzhong Wang, Yu Cui, Yongxing Chen, Deyun Zhang, Yong Liang, Dong Zhang, Qiuhong Wu, Jingzhong Xie, Shuhong Ouyang, Delin Li, Yinlian Huang, Ping Lu, Guoxin Wang, Meihua Yu, Shenghui Zhou, QixinSun, ZhiyongLiu* (2014) Comparative genetic mapping and genomic region collinearity analysis of the powdery mildew resistance gene Pm41.Theor Appl. Genet. 127:1741-1751Jingting Li, Zhenzhong Wang, Huiru Peng, ZhiyongLiu* (2014) A MITE insertion into the 3′-UTR regulates the transcription of TaHSP16.9 in common wheat. The Crop Journal 2:381-387Haibin Wu, Jinxia Qin, Jun Han, Xiaojie Zhao, Shuhong Ouyang, Yong Liang, Dong Zhang, Zhenzhong Wang, Qiuhong Wu, Jingzhong Xie, Yu Cui, Huiru Peng, Qixin Sun, ZhiyongLiu* (2013) Comparative High-Resolution Mapping of the Wax Inhibitors Iw1 and Iw2 in Hexaploid Wheat. PLoS ONE 8(12): e84691.Li L, D Li, S Liu, X Ma, CR Dietrich, HC Hu, G Zhang, Z Liu, J Zheng, G Wang, PS Schnable (2013) The maize glossy13 gene, cloned via BSR-Seq and Seq-Walking encodes a putative ABC transporter required for the normal accumulation of epicuticular waxes. Plos One 8(12): e82333. doi:10.1371/journal.pone.0082333Ziji Liu, Jie Zhu, Yu Cui, Yong Liang, Haibin Wu, Wei Song, Qing Liu, Tsomin Yang, Qixin Sun, ZhiyongLiu* (2012) Identification and Comparative Mapping of a Powdery Mildew Resistance Gene Derived from Wild Emmer (Triticumturgidum var. dicoccoides) on Chromosome 2BS. Theor Appl. Genet 124:1041-1049Yu Cui, Mi Yeon Lee, Naxin Huo, Jennifer Bragg, Lijie Yan, Cheng Yuan, Cui Li, Sara J. Holditch, Jingzhong Xie, Ming-Cheng Luo, Dawei Li, Jialin Yu, Joel Martin, Wendy Schackwitz, Yong Qiang Gu, John P. Vogel, Andrew O. Jackson*ZhiyongLiu*, and David F. Garvin (2012) Fine mapping of the Bsr1 barley stripe mosaic virus resistance gene in the model grass Brachypodiumdistachyon. Plos One 7(6): e38333.Mi Yeon Lee1, Lijie Yan, Florien A. Gorter, Brian Y.T Kim, Yu Cui, Yue Hu, Cheng Yuan, Jessica Grindheim, Uma Ganesan, ZhiyongLiu, Chenggui Han, Jialin Yu, Dawei Li and Andrew O. Jackson (2012) A pathogenicity determinant overcoming Brachypodiumdistachyon Bd3-1 resistance resides in the Triple Gene Block 1 movement protein of the Norwich strain of Barley stripe mosaic virus. J. ofGeneral Virology 93:2529-2756Tilin Fang, Kimberly G. Campbell, ZhiyongLiu, Xianming Chen, Anmin Wan, Shan Li, Ziji Liu, Shuanghe Cao, Yihua Chen, Robert L. Bowden, Brett F. Carver, and Liuling Yan (2011) Stripe rust resistance in the wheat cultivar Jagger is due to Yr17 and a novel resistance gene. Crop Science 51: 6: 2455-2465Cheng Yuan, Cui Li, Lijie Yan, Andrew O Jackson, ZhiyongLiu, Chenggui Han, Jialin Yu, Dawei Li (2011) A high throughput Barley Stripe Mosaic Virus vector for virus induced gene silencing in monocots and dicots. PLoS ONE 6(10): e26468.Hongtao Zhang, Haiying Guan, Jingting Li, Chaojie Xie, Xiayu Duan, Yilin Zhou, Tsomin Yang, Qixin Sun, ZhiyongLiu* (2010) Genetic and comparative genomics mapping reveals that a powdery mildew resistance gene Ml3D232originating from wild emmer co-segregates with an NBS-LRR analog in common wheat (Triticumaestivum L.). Theor Appl. Genet. 121:1613-1621The International Brachypodium Initiative (2010) Genome sequencing and analysis of the model grass Brachypodiumdistachyon. Nature 463:763-768Andrea L. Blas, Ray Ming, ZhiyongLiu, Olivia J. Veatch, Robert E. Paull, Paul H. Moore, Qingyi Yu (2010) Cloning of papaya chromoplast specific lycopene β-cyclase, CpCYC-b, controlling fruit flesh color revealed conservedmicrosynteny and a recombination hotspot. Plant Physiology 152:2013-2020Yanjie Wang, Huiru Peng, Gang Liu, Chaojie Xie, Zhongfu Ni, Tsomin Yang, ZhiyongLiu and Qixin Sun (2010) Identification and molecular mapping of a leaf rust resistance gene in spelt wheat landraceAltgold.Euphytica 174:371-375Genqiao Li, Tilin Fang, Hongtao Zhang, Chaojie Xie, Hongjie Li, Tsomin Yang, Eviatar Nevo, Tzion Fahima, Qixin Sun, ZhiyongLiu* (2009) Molecular identification of a new powdery mildew resistance gene Pm41on chromosome 3BL derived from wild emmer (Triticumturgidumvar.dicoccoides). Theor Appl Genet 119:531-539Wei Hua, Ziji Liu, Jie Zhu, Chaojie Xie, Tsomin Yang, Yilin Zhou, Xiayu Duan, Qixin Sun, ZhiyongLiu* (2009) Identification and genetic mapping of pm42, a new recessive wheat powdery mildew resistance gene derived from wild emmer (Triticumturgidumvar.dicoccoides). Theor Appl Genet 119:223-230Wei Song, Chaojie Xie, Jinkun Du, Hao Xie, Qing Liu, Zhongfu Ni, Tsomin Yang, Qixin Sun, ZhiyongLiu* (2009) A‘one-marker-for-two-genes’ approach for efficient molecular discrimination of Pm12 and Pm21 conferring resistance to powdery mildew in wheat. Molecular Breeding 23:357-363Hua W, Soltanloo H., Lu, J, Puchalski B, Frick M, Liu ZY, Laroche A, Gaudet D (2008) Expression of defence-related genes in wheat carrying Lr34/Yr18 genes for adult plant resistance to leaf rust. Canadian Journal of plant pathology 30:368-369Xiaoling Ji, Chaojie Xie, Zhongfu Ni, Tsomin Yang, Eviatar Nevo, Tzion Fahima, ZhiyongLiu, Qixin Sun (2007) Identification and genetic mapping of a powdery mildew resistance gene in wild emmer (Triticum dicoccoides) accession IW72 from Israel. Euphytica 159: 385-390Wei Song, Hao Xie, Qing Liu, Chaojie Xie, Zhongfu Ni, Tsomin Yang, Qixin Sun, ZhiyongLiu* (2007) Molecular identification of Pm12-carrying introgression lines in wheat using genomic and EST-SSR markers. Euphytica 158:95-102Qing Liu, Zhongfu Ni, Huiru Peng,Wei Song, ZhiyongLiu, Qixin Sun (2007) Molecular mapping of a dominant non-glaucousness gene from synthetic hexaploid wheat (Triticumaestivum L.). Euphytica 155:71-78Hongjie Li, R. L. Conner, ZhiyongLiu, Yiwen Li, Yu Chen, Yilin Zhou, Xiayu Duan, Tianmin Shen, Qin Chen, R. J. Graf, and Xu Jia (2007) Characterization of Wheat-Triticale Lines Resistant to Powdery Mildew, Stem Rust, Stripe Rust, Wheat Curl Mite, and Limitation on Spread of WSMV. Plant Disease 91(4):368-374Yingyin Yao, Zhongfu Ni, Yinhong Zhang, Yan Chen, Yuhua Ding, Zongfu Han, ZhiyongLiu, Qixin Sun (2005) Identification of Differentially Expressed Genes in Leaf and Root between Wheat Hybrid and Its Parental Inbreds Using PCR-based cDNA Subtraction. Plant Molecular Biology 58(3):367-384Susan Schenck, Heather M. Pearl, ZhiyongLiu, Paul H. Moore, and Ray Ming (2005) Genetic variation of Ustilago Scitaminea pathotypes in Hawaii evaluated by host range and AFLP markers. Sugar Cane International. 23(1):15-19ZhiyongLiu, Paul H. Moore, Hao Ma, Christine Ackerman, M. Ragiba, Qingyi Yu, P. Heather, Mina Kim, J. Charlton, J.I. Stiles, F.T. Zee, Andrew H. Paterson, Ray Ming. (2004) A primitive Y chromosome in papaya marks incipient sex chromosome evolution. Nature 427:348-352Hao Ma, Paul H. Moore, ZhiyongLiu, Mina S. Kim, Qingyi Yu, M.M.M. Fitch, T. Sekioka, Andrew H. Paterson, Ray Ming (2004) High-density linkage mapping revealed suppression of recombination at the sex determination locus in papaya. Genetics 166:419-436Denise Steiger, Paul H. Moore, F. Zee, ZhiyongLiu, Ray Ming (2003) Genetic relationship of macadamia cultivars and species revealed by AFLP markers. Euphytica 132: 269-277Deputy J. C., Ray Ming, Hao Ma, ZhiyongLiu, M. M. M. Fitch, M. Wang, R. Manshardt, J. I. Stiles (2002) Molecular markers for sex determination in papaya (Carica papaya L.). Theor Appl Genet 106:107-111ZhiyongLiu, Stephen O. Peter, Muhua Long, U. Weingartner, Peter Stamp and Oiliver Kaeser. (2002). A PCR assay for rapid discrimination of cytoplasm types in maize. Crop Sci. 42:566-569ZhiyongLiu, Qixin Sun, Zhongfu Ni, Eviatar Nevo, Tsomin Yang (2002) Molecular characterization of a powdery mildew resistance gene Pm30 in wheat originating from wild emmer (Triticumturgidum var. dicoccoides). Euphytica.123:21-29.Zhongfu Ni, Qixin Sun, ZhiyongLiu, Limin Wu, Xiaoling Wang. (2000) Identification of a hybrid-specific expressed gene encoding novel RNA-binding protein in wheat seedling leaves using differential display of mRNA. Mol Gen Genet.263:934-938ZhiyongLiu, Qixin Sun, Zhongfu Ni, Tsomin Yang (1999) Development of SCAR markers linked to the Pm21 gene conferring resistance to powdery mildew in wheat. Plant Breeding 118: 215-219ZhiyongLiu, Qixin Sun, Hongjie Li, Zhongfu Ni, Borang Tang, Aidong Yang, Tsomin Yang, Xu Jia (1999) Molecular identification and marker assisted selection of Pm21 gene conferring resistance to powdery mildew in wheat. Chinese Journal of Genetics 26:339-347Qixin Sun, Zhongfu Ni, ZhiyongLiu (1999) Differential gene expression between wheat hybrids and their parental inbreds in seedling leaves. Euphytica 106:117-123Qixin Sun, Zhongfu Ni, ZhiyongLiu, Jianwei Gao, Tiecheng Huang (1998) Genetic relationships and diversity among Tibetan wheat, common wheat and European spelt wheat revealed by RAPD makers. Euphytica 99:205-211