李新建

中国科学院生物物理研究所

浏览次数

15

收藏次数

0

接洽次数

0

  • 李新建
  • 研究员

李新建 博士 研究员 博士生导师

国家“青年千人计划”获得者

中国科学院生物物理所,中国科学院感染与免疫重点实验室,研究组Co-PI

研究方向:肿瘤与血管内皮细胞代谢重编程

电子邮件(E-mail) lixinjian(AT)ibp.ac.cn

电话(Tel) 010-64888557

邮政编码 100101

英文版个人网页

简历 & 研究组工作摘要

2019 - 至今 中国科学院生物物理研究所(研究员)

2016 - 2019 美国MD安德森癌症中心(讲师)

2011 - 2016 美国MD安德森癌症中心(博士后)

2007 - 2011 中山大学(博士)

2004 - 2007 华南理工大学(硕士)

2000 - 2004 华南农业大学(学士)

代表性奖励

2019 青年千人计划

2018 美中抗癌协会和美国亚洲癌症研究基金会(USCACA-AFCR)奖学金

2016 MD安德森癌症中心Caroline Ross Endowed Fellowship

2016 MD安德森癌症中心The Harold C. and Mary L. Daily Endowment Fund Fellowship

2015 MD安德森癌症中心The Anne Eastland Spears Fellowship

2013 MD安德森癌症中心Odyssey Fellowship

主要研究方向

细胞代谢重编程是肿瘤的重要特征之一。大量研究表明肿瘤细胞发生了代谢重编程,诸多代谢通路包括糖酵解、三羧酸循环、尿素循环、尿酸代谢、核酸代谢、脂肪酸代谢、胆固醇代谢、谷氨酰胺代谢、丝氨酸代谢、一碳单位代谢、胆碱代谢等,在肿瘤细胞中均发生了重编程变化。近年来,研究重要代谢异常在细胞恶性转化中的作用及其分子机制已成为活跃的国际学术前沿。我们课题组结合蛋白质组学、代谢组学、生物信息学以及转基因/基因敲除小鼠肿瘤模型研究肿瘤细胞的代谢物异常,通过深入探讨并回答肿瘤细胞如何感受代谢物异常、代谢异常在细胞恶性转化中的作用等重要前沿科学问题,为肿瘤预防、早期诊断和治疗提供新思路。

此外,我们课题组目前还对血管内皮细胞衰老过程中的代谢重编程感兴趣,致力于揭示血管内皮细胞从年轻到衰老转变过程中的代谢规律,为防治血管衰老提供理论依据。

代表性论文

1. Li XJ*, Qian X*, Jiang HF, Xia Y, Zheng YH, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z. Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Molecular Cell 2018; 72(4): 650-660

2. Li XJ*, Egervari G*, Wang YG, Berger SL, and Lu Z. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology 2018; 19(9): 563-578 (Cover story)

3. Qian X*, Li XJ* (co-first author), Tan L, Lee JH, Xia Y, Cai QS, Zheng YH, Wang HX, Lorenzi PL, and Lu Z. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery 2018; 8 (1): 94-107

4. Li XJ, Qian X and Lu Z. Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Autophagy 2017, 13(10): 1790-1791

5. Li XJ, Yu W, Qian X, Xia Y, Zheng YH, Lee JH, Li W, Lyu JX, Rao G, Zhang XC, Qian CN, Rozen SG, Jiang T, and Lu Z. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell 2017; 66 (5): 684-697 (Research Highlight of Nature Reviews Molecular Cell Biology)

6. Li XJ, Qian X, and Lu Z. Fructokinase A acts as a protein kinase to promote nucleotide synthesis. Cell Cycle 2016, 15(20): 2689-90

7. Li XJ, Qian X, Peng LX, Jiang YH, Hawke D, Zheng YH, Xia Y, Lee JH, Cote G, Wang HX, Wang LW, Qian CN, and Lu Z. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology 2016; 18 (5): 561-571(Research Highlight of Science Signaling)

8. Li XJ, Zheng YH, and Lu Z. PGK1 is a new member of the protein kinome. Cell Cycle 2016;15(14): 1803-4

9. Li XJ, Jiang YH, Meisenhelder J, Yang WW, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang LW, and Lu Z. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Molecular Cell 2016; 61 (5): 705-719

10. Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ,Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling.Carcinogenesis 2012; 33 (7): 1302-1309

11. Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.Cancer Research 2011;71 (8):3162-3172

12. Qian X, Li XJ, and Lu Z. Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis. Autophagy 2017, 13(7): 1246-1247

13. Qian X, Li XJ, Cai QS, Zhang CB, Yu QJ, Jiang YH, Lee JH, Hawke D, Wang YG, Xia Y, Zheng YH, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy. Molecular Cell 2017; 65 (5): 917-931

14. Zheng YH, Li XJ, Qian X, Wang YG, Lee JH, Xia Y, Hawke D, Zhang G, Lyn JX, and Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nature Cell Biology 2015; 17(10):1348-55

15. Jiang YH, Li XJ, Yang WW, Hawke D, Zheng YH, Xia Y, Aldape K, Wei CY, Guo F, Chen Y, Lu Z. PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells. Molecular Cell 2014; 53(1): 75-87

16. Li XJ, Qian CN.Serglycin in human cancers.Chin J Cancer 2011; 30 (9): 585-589

资料来源:李新建研究员,2019-11-22网页更新