卫涛涛

中国科学院生物物理研究所

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  • 卫涛涛
  • 研究员

卫涛涛 博士 研究员 博士生导师

中国科学院生物物理研究所,生物大分子国家重点实验室,研究组长

研究方向:细胞能量代谢

讲授课程:中国科学院大学本科生《细胞生物学》课程

电子邮件(E-mail) weitt(AT)ibp.ac.cn

电话(Tel) 010-64888566

邮政编码 100101

英文版个人网页

简历 & 研究组工作摘要

1989-1993年 华中科技大学,化学系,学士

1993-1996年 湖北省化学研究所,硕士

1996-1999年 中国科学院生物物理研究所,博士

1999-2001年 中国科学院生物物理研究所,助理研究员

2001-2008年 中国科学院生物物理研究所,副研究员

2008年-至今 中国科学院生物物理研究所,研究员

获奖情况

1999年,中国科学院院长奖

2018年,中国科学院大学生命科学学院精品课程

学术兼职

中国生物物理学会理事

中国生物物理学会膜生物学分会秘书长

中华预防医学会自由基预防医学专业委员会常务委员

中国生物物理学会自由基生物学分会理事

中国抗癌协会纳米肿瘤学专业委员会委员

《生物化学与生物物理进展》编委

研究方向

线粒体是细胞的能量代谢中心,也是细胞命运决定的调控中枢之一。在正常生理条件下,线粒体网络不断发生动态变化、实现稳态维持,通过进行能量代谢与物质代谢维持细胞生命活动;在特定病理条件下,线粒体稳态被破坏,直接影响线粒体的功能,对生命过程造成显著影响。本课题组结合结构生物学、单分子生物物理学、蛋白组学及修饰组学等技术手段发现了多种维持线粒体稳态的蛋白质机器,解析了它们影响细胞命运决定的分子机制,并揭示了它们参与代谢性疾病及恶性肿瘤发生发展的重要作用;还构建了一系列靶向线粒体、调控细胞能量代谢并有效阻遏肿瘤的纳米生物材料。

培养研究生获奖情况

赵凯,2011年,中国科学院三好学生标兵

周合江,2013年,国家奖学金;2014年,保罗生物科技奖学金

贺小龙,2015-2017年,中国科学院三好学生;2018年,所长奖学金一等奖

胡昊,2018年,所长奖学金二等奖

代表性论文(* 通讯作者):

1. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye, Taotao Wei* and Ming Li*. Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation. Nano Letters 19(2019), 6937-6944.

2. Peng Wei, Yan Xie, Peter W. Abel, Yapei Huang, Qin Ma, Linghai Li, Junfeng Hao, Dennis W. Wolff, Taotao Wei* and Yaping Tu*. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death and Disease 10(2019), 670.

3. Yang Xu, Jinqi Ren, Xiaolong He, Han Chen, Taotao Wei* and Wei Feng*. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 15(2019), 1017-1030.

4. Yipeng Du, Hao Hu, Xiaoxia Pei, Kang Du and Taotao Wei*. Genetically encoded FapR-NLuc as a biosensor to determine Malonyl-CoA in situ at subcellular scales. Bioconjugate Chemistry 30(2019), 826-832.

5. Yipeng Du*, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, JunfengHao, Pingsheng Liu, Fuquan Yang, Tingting Li* and Taotao Wei*. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis inob/ob mice. EBioMedicine 36(2018), 347-357.

6. Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, FugenShangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, DeyaoXie, Linhua Lan, XiangdongXue, Xingjie Liang, Bin Lv*, Taotao Wei* and Yan Qin*. Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch. Cancer Research 78(2018), 2813-2824.

7. Bo Zhang, PengWei, Zhixiang Zhou and Taotao Wei*. Interactions of graphene with mammalian cells: Molecular mechanismsand biomedical insights. Advanced Drug Delivery Reviews 105 (2016) 145–162.

8. Chuu-Yun A. Wong, Haihong Jiang, Peter W. Abel, Margaret A. Scofield, Yan Xie, Taotao Wei* and Yaping Tu*. Phorbolmyristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression. Protein & Cell 7(2016), 417-433.

9. Bo Zhang, Wei Chu, Peng Wei, Ying Liu and Taotao Wei*. Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I. Free Radical Biology & Medicine 89(2015), 486-497.

10. Yipeng Du, Tanxi Cai, Tingting Li, Peng Xue, Bo Zhou, Xiaolong He, Peng Wei, Pingsheng Liu, Fuquan Yang* and Taotao Wei*. Lysine malonylation is elevated in type 2 diabeticmouse models and enriched in metabolicassociated proteins. Molecular & Cellular Proteomics 14(2015), 227-236.

11. Bo Zhang, Jing Wang, Zhen Huang, Peng Wei, Ying Liu, Junfeng Hao, Lijing Zhao, Fenglin Zhang, Yaping Tu and Taotao Wei*. Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer. Oncotarget 6(2015), 44495-44508.

12. Teng Zhou, Meifang Yu, Bo Zhang, Liming Wang, Xiaochun Wu, Hejiang Zhou, Yipeng Du, JunfengHao, YapingTu, Chunying Chen* and Taotao Wei*. Inhibition of cancer cell migration by gold nanorods: molecular mechanisms and implications for cancer therapy. Advanced Functional Materials 24(2014), 6922-6932.

13. Qianqian Chen, Juan Zhang, Kai Zhao, Wei Li, Qi Miao, Yang Sun, Xingyu Zhao, Taotao Wei* and Fuyu Yang*. Lysosomal chymotrypsin inducesmitochondrial fission in apoptotic cellsby proteolytic activation of calcineurin. Protein & Cell 5(2014), 643-647.

14. Teng Zhou, Bo Zhang, Peng Wei, Yipeng Du, Hejiang Zhou, Meifang Yu, Liang Yan, Wendi Zhang, Guangjun Nie, Chunying Chen, Yaping Tu and Taotao Wei*. Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets. Biomaterials 35(2014), 9833-9843.

15. Hejiang Zhou, Bo Zhang, Jiajia Zheng, Meifang Yu, Teng Zhou, Kai Zhao, YanxiaJia, Xingfa Gao*, Chunying Chen* and Taotao Wei*. The inhibition of migration and invasion of cancer cells by graphenevia the impairment of mitochondrial respiration. Biomaterials 35(2014), 1597-1607.

16. Wenjuan Duan, Juefei Zhou, Wei Li, Teng Zhou, Qianqian Chen, Fuyu Yang* and Taotao Wei*. Plasma membrane calcium ATPase 4binhibits nitric oxide generation throughcalcium-induced dynamic interaction withneuronal nitric oxide synthase. Protein & Cell 4(2013), 286-298.

17. Kai Zhao, Hejiang Zhou, Xingyu Zhao, Dennis W. Wolff, YapingTu, Huili Liu,Taotao Wei* and Fuyu Yang*. Phosphatidic acid mediates the targeting of tBid toinduce lysosomal membrane permeabilizationand apoptosis. Journal of Lipid Research 53(2012), 2102-2114.

18. Hejiang Zhou, Kai Zhao, Wei Li, Na Yang, Ying Liu, Chunying Chen* and Taotao Wei*. The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways. Biomaterials 33(2012), 6933-6942.

19. Wei Li, Lina Zhao, Taotao Wei*, Yuliang Zhao* and Chunying Chen*. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles. Biomaterials 32(2011), 4030-4041.

20. Kai Zhao, Xingyu Zhao, YapingTu, Qi Miao, Dongxu Cao, WenjuanDuan, Yang Sun, Jincheng Wang, Taotao Wei* and Fuyu Yang*. Lysosomal chymotrypsin B potentiates apoptosis via cleavageof Bid. Cellular and Molecular Life Sciences 67(2010), 2665-2678.

资料来源:卫涛涛研究员,2019-10-10网页更新