- 焦仁杰
- 研究员
焦仁杰 博士 研究员 博士生导师 中国科学院生物物理所，脑与认知科学国家重点实验室，研究组长 研究方向：Mechanisms of cell proliferation and differentiation （细胞增殖与分化的机制） 电子邮件(E-mail ) rjiao@ibp.ac.cn 电话(Tel) 010-64867568 传真(Fax) 010-64871293 邮政编码 100101 英文版个人网页 |
简历 & 研究组工作摘要
焦仁杰研究员1965年1月30日生于江苏、泰兴。1987年毕业于北京大学生物学系细胞生物学及遗传学专业，获学士学位。1991年获北京大学细胞生物学硕士学位。同年留校任教。历任助教、讲师。1999年获苏黎世大学分子生物学研究所博士学位。2004年受聘于中国科学院生物物理研究所，任课题组长。2011年获中国科学院优秀导师称号。2017年受聘于广州医科大学，任课题组长、中法霍夫曼研究所所长。现任《Journal of Genetics and Genomics》副主编；英国癌症研究基金会(Cancer Research UK)、奥地利国家自然科学基金（Austrian National Science Foundation）等基金评审人；《Nature Communications》、《Journal of Cell Science》、《Journal of Molecular Cell Biology》等科技期刊论文评阅人。国家自然科学基金委二审专家。
焦仁杰实验室主要研究方向是：细胞增殖与分化和细胞免疫调控的信号转导机制。他至今已在 Nature Cell Biol., Dev. Cell, Cell Res., Nat. Commun., Cancer Res., Development, Genetics, Mol. Cell. Biol., Mol. Biol. Cell, J. Cell Sci., Oncogene, J. Neurosci.等专业期刊上发表研究论文七十多篇。
研究团队/课题组成员
梁雪红 高级实验师 Email: liang@moon.ibp.ac.cn | 伍洪刚 博士生 Email: whg9014@163.com |
朱南南 博士生 Email: nannanzhu88@hotmail.com | 郭雅文 博士生 Email: yawen_guo90@hotmail.com |
学生获奖
宋延俊 2007 所长奖二等奖
杜贵平 2010 朱李月华奖
黄海 2011 院长奖特别奖
于忠胜 2013 国家奖学金
伍洪刚 2015 国家奖学金
代表性论文（2010 - 2018）
焦仁杰实验室近年发表论文（2010 - 2018）：
1. Chen, J., N. Xu, C. Wang, P. Huang, H. Huang, Z. Jin, Z. Yu, T. Cai, R. Jiao and R. Xi. 2018. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nature Cell Biol., 20(2): 152-161.
2. H. WANG, Y. Yan, L. Min, L.-Y. ZHU, D.-Y. Zhang, R.Jiao*. 2017. CRISPR/Cas9 System: an Important Tool for Brain and Cognitive Science. Prog. Biochem. Biophys., 44(9): 799~805. [Perspectives]
3. Yan, Y., H. Wang, M. Hu, L. Jiang, Y. Wang, P. Liu, X. Liang, J. Liu, C. Li, A. Lindstr？m-Battle, W.-M. Deng and R. Jiao*. 2017. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Dev. Cell. 43: 99–111.
4. Jiao, R.* and C. Gao*. 2017. Anything impossible with CRISPR/Cas9? Sci China: Life Sci., 60: 445-446. [Editorial review]
5. Xie, G., H. Chen, D. Jia, Z. Shu, W. Palmer, X. Zeng, S. Hou, R. Jiao* and W.-M. Deng*, 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res., 77: 862-873.
6. Jiao, R.* and C. Gao*. 2016. The CRISPR/Cas9 genome editing revolution. J. Genet. Genomics, 43: 227-228. [Editorial review]
7. Yan, Y., Y. Zhu, L. Liu and R. Jiao*. 2016. Transgenerational epigenetic inheritance of learning and memory: can flies tell us the truth? PiBB, 43: 337 – 347. [review]
8. Peng, Q., Y. Wang, M. Li, D. Yuan, M. Xu, C. Li, Z. Gong, R. Jiao* and L. Liu*. 2016. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function. J. Neurosci. 36: 4635 - 4646.
9. Yan, Y. and R. Jiao*. 2016. HDAC6: A Molecule with Multiple Functions in Neurodegenerative Diseases. pp: 146-165. In “The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria”. Eds: V. K. Gribkoff, E. A. Jonas and J. M. Hardwick. John Wiley & Sons, Inc. [invited book chapter]
10. Liu J., Y. Guo, C. Li, Y. Chen and R. Jiao* 2016. Methods for TALEN-Mediated Genomic Manipulations in Drosophila. Pp: 179-190. In “Methods in Molecular Biology” Series 1338 – Book: TALEN – Methods and Protocols. Eds: R. Kühn, W. Wurst and B. Wefers. Humana Press, Springer New York Heidelberg Dordrecht London. [invited book chapter]
11. Su, F., Z. Huang, Y. Guo, R. Jiao, Z. Li, J. Chen, J. Liu. 2016. From random mutagenesis to precise genome editing: the development and evolution of genome editing techniques in Drosophila. Hereditas (Beijing), 38: 17―27.
12. Zhu N., H. Wu, B. Yang, C. Li and R. Jiao*. 2015. F-Box Proteins: Multiple Functions Through One Platform. Gene Gene Edit., 1: 126-136. [invited review]
13. Wu, H., Manu, R. Jiao and J. Ma. 2015. Temporal and spatial dynamics of scaling-specific features of a gene regulatory network. Nature Communications, 6: 10031.
14. Yan Y., H. Wang, H. Chen, A. Lindstr？m-Battle and R. Jiao*. 2015. Ecdysone and Insulin Signaling Play Essential Roles in Readjusting the Altered Body Size Caused by the dGPAT4 Mutation in Drosophila. J. Genet. Genomics, 42: 487-494.
15. He, F.#, C. Wei#, H. Wu, D. Cheung, R. Jiao and J. Ma. 2015. Fundamental origins and limits for scaling a maternal morphogen gradient. Nature Communications, 6: 6679. DOI: 10.1038/ncomms7679
16. Yu, Z., J. Liu, W.-M. Deng and R. Jiao*. 2015. Histone chaperone CAF-1: essential roles in multi-cellular organism development. Cell. Mol. Life Sci., 72(2): 327-337. [invited review]
17. Zhang, H.#, C. Li#, H. Chen, H. Wu, W. Dui, F. Dai, W.-M. Deng* and R. Jiao*. 2015. SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Res., 25: 93-109.
18. Xie, G., Z. Yu, D. Jia, R. Jiao* and W.-M. Deng*. 2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. J. Cell Sci., 127: 3830 – 3839.
19. Liu, J., Y. Chen and R. Jiao*. 2014. TALEN-Mediated Drosophila Genome Editing: Protocols and Applications. Methods, 69: 22-31.
20. Yu, Z.#, H. Chen#, J. Liu, H. Zhang, Y. Yan, N. Zhu, Y. Guo, B. Yang, Y. Chang, F. Dai, X. Liang, Y. Chen, Y. Shen, W.-M. Deng, J. Chen, B. Zhang, C. Li*, and R. Jiao*. 2014. Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome. Biol. Open, 3: 271-280.
21. Yu, Z., M. Ren, Z. Wang, B. Zhang, Y.S. Rong, R. Jiao* and G. Gao*. 2013. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics, 195: 289-291.
22. Yu, Z., H. Wu, H. Chen, R. Wang, X. Liang, J. Liu, C. Li, W.-M. Deng* and R. Jiao*. 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development. Development, 140: 3635-3644.
23. Dui, W., B. Wei, F. He, W. Lu, C. Li, X. Liang, J. Ma* and R. Jiao*. 2013. The Drosophila F-box protein dSkp2 regulates cell proliferation through targeting Dacapo for degradation. Mol. Biol. Cell., 24: 1676-1687.
24. Wei, C., J. Liu, Z. Yu, B. Zhang*, G. Gao* and R. Jiao*. 2013. TALEN or Cas9 -- rapid, efficient and specific choices for genomic modifications. J. Genet. Genomics, 40: 281-289.
25. Zhang, Q., J. Wu, R. Wu, J. Ma, G. Du, R. Jiao, Y. Tian, Z. Zheng, Z. Yuan. 2012. DJ-1 Promotes the Proteasomal Degradation of Fis1: Implication of DJ-1 in the Neuronal Protection. Biochem. J., 447: 261-269.
26. Zhou, C., H. Huang, S. Kim, H. Lin, X. Meng, K.-A. Han, A.-S. Chiang, J. W. Wang, R. Jiao, and Y. Rao. 2012. Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J. Neurosci., 32: 14281–14287.
27. Wu, Q., J. Liu, Y. Chen and R. Jiao*. 2012. dCAF-1-p55 is essential for Drosophila development and involved in the maintenance of chromosomal stability. Prog. Biochem. Biophys., 39: 1073-1081.
28. Dui, W., W. Lu, J. Ma* and R. Jiao*. 2012. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. J. Genet. Genomics, 39: 397-413.
29. Xie, G., H. Zhang, G. Du, Q. Huang, X. Liang, J. Ma* and R. Jiao*. 2012. Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. PLoS One, 7: e36362.
30. Liu, J., C. Li, Z, Yu, P. Huang, H. Wu, C. Wei, N. Zhu, Y. Shen, Y. Chen, B. Zhang, W.-M. Deng* and R. Jiao*. 2012. Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J Genet Genomics, 39: 209-215.
31. Huang, H. and R. Jiao*. 2012. The roles of chromatin assembly factor 1 in the epigenetic control of chromatin plasticity. Sci. China Life Sci., 55: 15-19. [invited review]
32. Huang, H., N. Zhu and R. Jiao*. 2011. The sumoylation pathway modulates JNK signaling in Drosophila. Prog. Biochem. Biophys., 38: 568-574. [Scientific News and Perspectives]
33. Liu, J., Q. Wu, D. H, T. Ma, L. Du, W. Dui, X. Guo and R. Jiao*. 2011. Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. J. Genet. Genomics, 38: 225-234.
34. Huang, H., G. Du, H. Chen, X. Liang, C. Li, N. Zhu, L. Xue, J. Ma and R. Jiao*. 2011. Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development, 138: 2477-2485.
35. Du, G. and R. Jiao*. 2011. To prevent neurodegeneration: HDAC6 uses different strategies for different challenges. Commun. Integr. Biol., 4: 139-142. [Invited review]
36. Huang, H., Z. Yu, S. Zhang, X. Liang, J. Chen, C. Li, J. Ma and R. Jiao*. 2010. Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. J. Cell Sci., 123: 2853-2861.
37. Yu, Z. and R. Jiao*. 2010. Advances in Drosophila gene targeting and related techniques. Front. Biol., 5(3): 238-245. [Invited review]
38. Chen, Y., W. Dui, Z. Yu, C. Li, J. Ma and R. Jiao*. 2010. Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo. Protein & Cell. 1(5): 478-490.
39. Du, G., X. Liu, X. Chen, M. Song, Y. Yan, R. Jiao* and C.-C. Wang*. 2010. Drosophila histone deacetylase 6 protects dopaminergic neurons against α-synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell. 21: 2128-2137.
40. He, F., Y. Wen, D. Cheung, J. Deng, L.J. Lu, R. Jiao* and J. Ma*. 2010. Distance measurements via the Bicoid morphogen gradient in Drosophila embryos. BMC Dev. Biol., 10: 80-93.
41. He, F., T. Saunders, Y. Wen, D. Cheung, R. Jiao, P. Rein ten Wolde, M. Howard, and J. Ma. 2010. Shaping a morphogen gradient for positional precision. Biophys. J. 99: 97-107.
教材编著：
1、陈毅序、焦仁杰。2011年10月。染色质可塑性与基因组稳定性（第四章）。《分子细胞生物学》（第二版）主编：陈晔光、张传茂、陈佺。清华大学出版社。北京
2、焦仁杰。2011年6月。细胞核与染色质（第十一章）。《细胞生物学》（第四版）主编：翟中和、王喜中、丁明孝。高等教育出版社。北京。
教材翻译：
1、谢更强、焦仁杰。2011年3月。精编干细胞生物学研究方法。pp408-483。科学出版社。北京。
2、焦仁杰。2009年1月。精编干细胞生物学。pp56-70 and 90-105。科学出版社。北京。
资料来源：焦仁杰研究员，2018-04-26网页更新
