渠鸿竹

中国科学院北京基因组研究所

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  • 渠鸿竹
  • 硕士生导师
  • 研究员

渠鸿竹 ( QU Hongzhu )

职 称: 副研究员
职 务: 硕士生导师
E-Mail: quhongzhu@big.ac.cn
学科类别: 基因组学,生物信息学
学习经历:
2000年9月-2004年7月 东北农业大学 生物技术专业 理学学士学位 2004年9月-2009年6月 中国科学院北京基因组研究所 基因组学专业 理学博士学位
工作经历:

2015年1月至今 中国科学院北京基因组研究所 副研究员

2009年10月-2012年9月 美国华盛顿大学基因组科学系 访问学者

2009年7月-2014年12月 中国科学院北京基因组研究所 助理研究员

主要研究领域:

生物信息学,肿瘤组学研究与转化

承担科研项目情况:

1.国家重点研发计划,精准医疗临床决策支持系统研发,2018.6-2020.12,在研,参加;

2.国家自然科学基金青年基金,FOXO3调控脐血干细胞红系分化的系统组学数据挖掘,2015.01-2017.12,结题,主持;

3.法医遗传学公安部重点实验室开放性课题,DNA甲基化与年龄推断模型建立与验证评估,2014.12-2016.11,结题,主持;

4.诺和诺德与中国科学院联合基金, Identify novel SLE targets using GWAS and ENCODE non-coding variants, 2013.03-2015.02,结题,主持;

5.中国科学院人才项目,中国科学院青年创新促进会,2014.01-2017.12,结题,主持;

6.中国科学院知识创新工程青年人才领域前沿项目,基于DNase-Seq与ChIP-Seq等组学数据研究红细胞分化的调控机制,2011.07-2013.06,结题,主持;

7.科技部973项目,肿瘤异质性的转录组和蛋白质组研究,2014.01-2018.08,结题,参加;

8.国家自然科学基金面上项目,转录因子KLFs调控干细胞红系分化的分子网络机制,2015.01-2018.12,结题,参加;

9.中国科学院战略性科技先导专项子课题,利用高通量组学平台和系统生物学分析技术筛选肿瘤干细胞的特异性标记物和治疗靶点,2012.07-2016.12,结题,参加。

代表论著:

1. Yang Y, Zhang T, Xiao R, Hao X, Zhang H, Qu H, Xie B, Wang T, Fang X. Platform-independent approach for cancer detection from gene expression profiles of peripheral blood cells. Brief Bioinform. 2019. pii: bbz02

2. Zhang Q, Ding N, Zhang L, Zhao X, Yang Y, Qu H, Fang X. Biological Databases for Hematology Research. Genomics Proteomics Bioinformatics. 2016;14(6):333-337.

3. Li Y, Zhang Q, Du Z, Lu Z, Liu S, Zhang L, Ding N, Bao B, Yang Y, Xiong Q, Wang H, Zhang Z, Qu H, Jia H, Fang X. MicroRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB. Br J Haematol. 2017;176(1):50-64

4. Li Y, Liu S, Sun H, Yang Y, Qi H, Ding N, Zheng J, Dong X, Qu H, Zhang Z, Fang X. MiR-218 Inhibits Erythroid Differentiation and Alters Iron Metabolism by Targeting ALAS2 in K562 Cells. Int J Mol Sci. 2015;16(12):28156-68

5. Xu C#, Qu H#, Wang G#, Xie B, Shi Y, Yang Y, Zhao Z, Hu L, Fang X, Yan J, Feng L. A novel strategy for forensic age prediction by DNA methylation and support vector regression model. Sci Rep. 2015;5:17788

6. Liang F#, Qu H#, Lin Q#, Yang Y, Ruan X, Zhang B, Liu Y, Yu C, Zhang H, Fang X, Hao X. Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes. World J Surg Oncol. 2015;13:258

7. Wang H, Li Y, Wang S, Zhang Q, Zheng J, Yang Y, Qi H, Qu H, Zhang Z, Liu F, Fang X*. Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. Biochem Biophys Res Commun. 2015; 460(4):923-30.

8. Yang Y, Dong X, Xie B, Ding N, Chen J, Li Y, Zhang Q, Qu H, Fang X*. Databases and Web Tools for Cancer Genomics Study. Genomics Proteomics & Bioinformatics. 2015; 13(1):46-50.

9. Yang Y, Wang H, Chang KH, Qu H, Zhang Z, Xiong Q, Qi H, Cui P, Lin Q, Ruan X, Yang Y, Li Y, Shu C, Li Q, Wakeland EK, Yan J, Hu S, Fang X*. Transcriptome dynamics during human erythroid differentiation and development. Genomics. 2013; 102(5-6):431-41.

10. Chang KH, Huang A, Han H, Jiang Y, Fang X, Song CZ, Padilla S, Wang H, Qu H, Stamatoyannopoulos J, Li Q, Papayannopoulou T*. Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny. Exp Hematol. 2013; 41(11):967-979.

11. Xiong Q, Zhang Z, Chang KH, Qu H, Wang H, Qi H, Li Y, Ruan X, Yang Y, Yang Y, Li Y, Sandstrom R, Sabo PJ, Li Q, Stamatoyannopoulos G, Stamatoyannopoulos JA, Fang X*. Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors. BMC Genomics. 2013; 14:587.

12. Qu H, Fang X*. A brief review on the Human Encyclopedia of DNA Elements (ENCODE) project. Genomics Proteomics & Bioinformatics. 2012; 11(3):135-41.

13. Wang H#, Maurano MT#, Qu H#, Varley KE, Gertz J, Pauli F, Lee K, Canfield T, Weaver M, Sandstrom R, Thurman RE, Kaul R, Myers RM, and Stamatoyannopoulos JA*. Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res. 22(9): 2012; 1680-8. (# Contributed equally)

14. Maurano MT#, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, Shafer A, Neri F, Lee K, Kutyavin T, Stehling-Sun S, Johnson AK, Canfield TK, Giste E, Diegel M, Bates D, Hansen RS, Neph S, Sabo PJ, Heimfeld S, Raubitschek A, Ziegler S, Cotsapas C, Sotoodehnia N, Glass I, Sunyaev SR, Kaul R, and Stamatoyannopoulos JA*. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012; 337(6099): 1190-5.(# Contributed equally)

15. Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC., Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, Canfield TK, Diegel M, Dunn D, Ebersol AK, Frum T, Giste E, Johnson AK, Johnson EM, Kutyavin T, Lajoie B, Lee BK, Lee K, London D, Lotakis D, Neph S, Neri F, Nguyen ED, Qu H, Reynolds AP, Roach V, Safi A, Sanchez ME, Sanyal A, Shafer A, Simon JM, Song L, Vong S, Weaver M, Yan Y, Zhang Z, Zhang Z, Lenhard B, Tewari M, Dorschner MO, Hansen RS, Navas PA, Stamatoyannopoulos G, Iyer VR, Lieb JD, Sunyaev SR, Akey JM, Sabo PJ, Kaul R, Furey TS, Dekker J, Crawford GE, and Stamatoyannopoulos JA*. The accessible chromatin landscape of the human genome. Nature. 2012; 489(7414): 75-82.

16. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012; 489(7414): 57-74.

17. Wu H, Qu H, Wan N, Zhang Z, Hu S, and Yu J*. Strand-biased gene distribution in bacteria is related to both horizontal gene transfer and strand-biased nucleotide composition. Genomics Proteomics & Bioinformatics. 2012; 10(4): 189-96.

18. Qu H, Wu H, Zhang T, Zhang Z, Hu S, Yu J*. Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes. Res Microbiol. 2010; 161(10):838-46.

19. Song S, Huang Y, Wang X, Wei G, Qu H, Wang W, Ge X, Hu S, Liu G, Liang Y, Yu J*. HRGD: a database for mining potential heterosis-related genes in plants. Plant Mol Biol. 2009; 69(3):255-60.

20. Song S#, Qu H#, Chen C, Hu S, Yu J*. Differential gene expression in an elite hybrid rice cultivar (Oryza sativa, L) and its parental lines based on SAGE data. BMC Plant Biol. 2007;7:49

社会任职:
获奖及荣誉:

2013年 2014年度中国科学院青年创新促进会会员