和夫红

中国科学院北京基因组研究所

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  • 和夫红
  • 研究员

和夫红 ( HE Fuhong )

职 称: 副研究员
职 务:
E-Mail: hefh@big.ac.cn
学科类别: 基因组学,生物信息学
学习经历:
2000年9月-2004年7月 安徽大学 生物科学专业 理学学士学位 2004年9月-2009年7月 中国科学院北京基因组研究所 基因组学专业 理学博士学位
工作经历:

2015年1月至今 中国科学院北京基因组研究所 副研究员

2009年7月-2014年12月 中国科学院北京基因组研究所 助理研究员

主要研究领域:

白血病的基因组学与表观遗传学

承担科研项目情况:

1. 江苏省科技计划项目(社会发展),儿童急性髓系白血病化疗耐药的新靶点与血浆分子标记物研究,2017.07-2020.06,在研,参加;

2. 国家自然科学基金面上项目,组蛋白去甲基化酶LSD1的抑制剂通过调节转录因子治疗MLL白血病的研究,2015.01-2018.12,结题,主持;

3. 中国科学院青年人才项目,中国科学院青年创新促进会会员,2015.01-2018.12,结题,主持;

4. 科技部973项目,肿瘤异质性的基因组和表观遗传机制,2014.01-2018.08,结题,参加;

5. 中国科学院战略性先导科技专项,儿童白血病化疗耐药基因突变和新靶标SETD2的功能研究,2016.01-2017.12,结题,参加;

6. 国家自然科学基金重大研究计划项目(培育),药物干预下选择肿瘤细胞增殖的基因组变异与进化规律,2014.01-2016.12,结题,参加;

7. 国家自然科学基金青年科学基金项目,转录因子AML1特异性募集组蛋白修饰酶MLL在白血病发病机制中的作用,2011.01-2013.12,结题,主持;

8. 中国科学院北京基因组研究所青年人才领域前沿项目,转录因子PU.1调控造血干细胞向粒系和淋巴系前体细胞定向分化的机制研究,2009.09-2011.08,结题,主持。

代表论著:

1) Peng Zhang#, Fuhong He#, Jie Bai#, Shohei Yamamoto, Shi Chen, Lin Zhang, Mengyao Sheng, Lei Zhang, Ying Guo, Na Man, Hui Yang, Suyun Wang, Tao Cheng, Stephen D. Nimer, Yuan Zhou, Mingjiang Xu*, Qian-Fei Wang*, Feng-Chun Yang*. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. Journal of Clinical Investigation. 2018.12.03;128(12):5383-5398. (1区, 共同第一, IF(2018)=12.282) 2) Jianping Li#, Fuhong He#, Peng Zhang#, Shi Chen, Hui Shi, Yanling Sun, Ying -Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen -D. Nimer, Peng Yu, Qian-Fei Wang*, Mingjiang Xu*, Feng-Chun Yang*. Loss of Asxl2 leads to myeloid malignancies in mice. Nature Communications. 2017.06.08;8:15456. (2区, 共同第一, IF(2018)=11.878) 3) Xiaofan Zhu#, Fuhong He#, Huimin Zeng#, Shaoping Ling#, Aili Chen#, Yaqin Wang, Xiaomei Yan, Wei Wei, Yakun Pang, Hui Cheng, Chunlan Hua, Yue Zhang, Xuejing Yang, Xin Lu, Lihua Cao, Lingtong Hao, Lili Dong, Wei Zou, Jun Wu, Xia Li, Si Zheng, Jin Yan, Jing Zhou, Lixia Zhang, Shuangli Mi, Xiaojuan Wang, Li Zhang, Yao Zou, Yumei Chen, Zhe Geng, Jianmin Wang, Jianfeng Zhou, Xin Liu, Jianxiang Wang, Weiping Yuan, Gang Huang*, Tao Cheng*, Qian-fei Wang*, Identification of functional cooperative mutations of SETD2 in human acute leukemia, Nature Genetics, 2014.02.09, 46(3):287~293. (1区, 共同第一, IF(2018)=25.455) 4) Xuejing Yang#, Yedan Lu, Fuhong He, Fenxia Hou, Caihong Xing*, Peiyu Xu*, Qian-fei Wang*. Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway. Carcinogenesis. 2019.02.16. pii: bgy157. doi: 10.1093/carcin/bgy157. (2区, IF(2018)=4.004) 5) Yixin Hu#, Aili Chen#, Xinchang Zheng#, Jun Lu#, Hailong He, Jin Yang, Ya Zhang, Pinpin Sui, Jingyi Yang, Fuhong He, Yi Wang, Peifang Xiao, Xin Liu, Yinmei Zhou, Deqing Pei, Cheng Cheng, Raul C. Ribeiro*, Shaoyan Hu*, Qian-fei Wang*. Ecological Principle Meets Cancer Treatment: Treating Children with Acute Myeloid Leukemia with Low-Dose Chemotherapy. National Science Review, nwz006. 22 January 2019. (1区, IF(2018)=13.222) 6) Yingchi Zhang#, Yufeng Gao#, Hui Zhang#, Jingliao Zhang, Fuhong He, Ale? Hnízda, Maoxiang Qian, Xiaoming Liu, Yoshihiro Gocho, Ching-Hon Pui, Tao Cheng, Qianfei Wang, Jun J Yang*, Xiaofan Zhu*, Xin Liu*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood. 2018.05.17. 131(20):2256-2261. (1区, IF(2018)=16.562) 7) Jiachen Bu#, Aili Chen, Xiaomei Yan, Fuhong He, Yunzhu Dong, Yile Zhou, Jianlin He, Di Zhan, Peipei Lin, Yoshihiro Hayashi, Yanling Sun, Yue Zhang, Zhijian Xiao, H. Leighton Grimes, Qian-Fei Wang*, Gang Huang*. SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia. 2018.04, 32(4):890-899. (1区, IF(2018)=9.944) 8) Peng Zhang#,Caihong Xing#,Steven D. Rhodes,Yongzheng He,Kai Deng,Zhaomin Li,Fuhong He,Caiying Zhu,Nguyen Lihn,Yuan Zhou,Shi Chen,Khalid S. Mohammad,Theresa A. Guise,Omar Abdel-Wahab,Mingjiang Xu,Qian-Fei Wang*,Feng-Chun Yang*,Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cells, Leading to Bohring-Opitz-like Syndrome in Mice,Stem Cell Reports,2016.06.14,6(6):914~925. (1区, IF(2018)=5.449) 9) 杨雪静#,和夫红,黄伊子,闫进,王前飞*,组蛋白去甲基化酶LSD1抑制剂对MLL-ENL白血病细胞诱导分化的研究,发育医学电子杂志,2015.4.30,(02):91~95. 10) Xinghui Zhao#,Aili Chen#,Xiaomei Yan,Yue Zhang,Fuhong He,Yoshihiro Hayashi,Yunzhu Dong,Yalan Rao,Bo Li,Rajeana M. Conway,Alba Maiques-Diaz,Shannon E. Elf,Nuomin Huang,Johannes Zuber,Zhijian Xiao,William Tse,Daniel G. Tenen,Qian-fei Wang,Wei Chen,James C. Mulloy,Stephen D. Nimer,Gang Huang*,Downregulation of RUNX1/CBFb by MLL fusion proteins enhances hematopoietic stem cell self-renewal,Blood,2014.3.13,123(11):1729~1738. (1区, IF(2018)=16.562) 11) Jing Zhou#,Jun Wu#,Bo Li#,Dan Liu,Jian Yu,Xiaomei Yan,Si Zheng,Jiguang Wang,Lixia Zhang,Lin Zhang,Fuhong He,Qiang Li,Aili Chen,Yue Zhang,Xinghui Zhao,Yinghui Guan,Xiaohong Zhao,Jin Yan,Jun Ni,Marcelo Nobrega,Bob L?wenberg,Ruud Delwel,Peter J. Valk,Ashish Kumar,Lu Xie,Daniel G. Tenen,Gang Huang*,Qian-fei Wang*,PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway,Leukemia,2014.01.21,28(7):1436~1448 (1区, IF(2018)=9.944) 12) Chunlan Hua#,Huidong Guo,Jiachen Bu,Mi Zhou,Hui Cheng,Fuhong He,Jinhong Wang,Xiaomin Wang,Yinchi Zhang,Qian-fei Wang,Jianfeng Zhou,Tao Cheng,Mingjiang Xu,Weiping Yuan*,Rictor/mammalian target of rapamycin 2 regulates the development of notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3,Experimental Hematology,2014.12.01,42(12):1031~1040. (3区, IF(2018)=2.462) 13) Yanfeng Liu#,Hui Cheng#,Shuai Gao,Xin Lu,Fuhong He,Linping Hu,Di Hou,Zhengyong Zou,Yanxin Li,Hongyan Zhang,Jing Xu,Lan Kang,Qian-fei Wang,Weiping Yuan,Shaorong Gao*,Tao Cheng*,Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells,Leukemia (2014),2013.11.15,28(5):1071~1080. (1区, IF(2018)=9.944) 14) Qian-Fei Wang#*,Yajun Li,Jingfang Dong,Bo Li,Joseph J. Kaberlein,Lin Zhang,Fábio Eiji Arimura,Roger T. Luo,Jun Ni,Fuhong He,Jun Wu,Ryan Mattison,Jing Zhou,Chongzhi Wang,Shyam Prabhakar,Marcelo Nobrega,Michael J. Thirman*,Regulation of MEIS1 by distal enhancer elements in acute leukemia,Leukemia (2014),2013.10.15,28(1):138~146. (1区, IF(2018)=9.944) 15) Gang Wu#,Jiang Zhu,Fuhong He,Weiwei Wang,Songnian Hu,Jun Yu*,Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs),Plos One,2012.10.10,7(10):e46961~e46973. (3区, IF(2018)=2.776) 16) Qian-fei Wang#,George Wu,Shuangli Mi,Fuhong He,Jun Wu,Jingfang Dong,Roger T. Luo,Ryan Mattison,Joseph J. Kaberlein,Shyam Prabhakar,Hongkai Ji,Michael J. Thirman*,MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome,Blood,2011.06.23,117(25):6895~6905. (1区, IF(2018)=16.562) 17) Jiang Zhu#,Fuhong He,Dapeng Wang,Kan Liu,Dawei Huang,Jingfa Xiao,Jiayan Wu,Songnian Hu,Jun Yu*,A Novel Role for Minimal Introns: Routing mRNAs to the Cytosol,Plos One,2010.4.12,5(4):e10144~e10151. (3区, IF(2018)=2.776) 18) Dapeng Wang#,Song Zhang,Fuhong He,Jiang Zhu,Songnian Hu,Jun Yu*,How Do Variable Substitution Rates Influence Ka and Ks Calculations?,Genomics, Proteomics & Bioinformatics,2009.9.1,7(3):116~127. (1区, IF(2018)=6.597) 19) Jiang Zhu#,Fuhong He#,Songnian Hu,Jun Yu*,On the nature of human housekeeping genes,Trends in Genetics,2008.09.09,24(10):481~484. (1区, 共同第一, IF(2018)=10.627) 20) Jiang Zhu#,Fuhong He#,Shuhui Song,Jing Wang*,Jun Yu*,How many human genes can be defined as housekeeping with current expression data?,BMC Genomics,2008.4.16,9(1):172~182. (2区, 共同第一, IF(2018)=3.501) 21) Jiang Zhu#,Fuhong He,Jing Wang*,Jun Yu*,Modeling Transcriptome Based on Transcript-Sampling Data,Plos One,2008.2.20,3(2):e1659~e1667. (3区, 共同第一, IF(2018)=2.776)

社会任职:
1.中国研究型医院学会血液病精准诊疗专业委员会,委员 2.中国科学院青年创新促进会,会员
获奖及荣誉:

1.2018年,基因组医学前沿与健康普惠论坛海报评比一等奖

2.2014年,2015年度中国科学院青年创新促进会会员

3.2009年,中国科学院地奥奖学金(二等奖)

4.2004年,安徽省品学兼优毕业生