陈艾莉

中国科学院北京基因组研究所

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  • 陈艾莉
  • 研究员

陈艾莉 ( Aili Chen )

职 称: 副研究员
职 务:
E-Mail: chenal@big.ac.cn
学科类别: 基因组学
学习经历:

2005年9月-2009年7月 山东农业大学 生物技术专业 理学学士学位

2006年6月-2009年6月 山东农业大学 英语专业 文学学士学位

2009年9月-2014年6月 中国科学院北京基因组研究所 基因组学专业 理学博士学位

工作经历:

2012年4月-2014年4月 美国辛辛那提儿童医院医学中心 访问学者

2014年7月-2019年7月 中国科学院北京基因组研究所 助理研究员

2019年7月至今 中国科学院北京基因组研究所 副研究员

主要研究领域:
白血病精准基因组医学研究
承担科研项目情况:

1.国家自然科学基金面上项目,单细胞组学技术鉴定白血病化疗耐药的恶性细胞亚群及关键分子,2020.01-2023.12,在研,项目负责人;

2.中国科学院青年创新促进会,人才项目,2019.01-2022.12,在研,项目负责人;

3.国家自然科学基金青年科学基金项目,组蛋白修饰酶SETD2功能缺失促进MLL白血病发生的表观遗传调控机制,2016.01-2018.12,已结题,项目负责人;

4.儿科重大疾病研究教育部重点实验室开放课题,AIF1在MLL白血病中的致病机制研究,2015.03-2016.12,已结题,项目负责人;

5.CancerFree KIDS,Identification and Targeting Mutations of a Novel Tumor Suppressor SETD2 in Pediatric Cancer,2013.04-2014.04,已结题,项目负责人;

6.中国科学院重点部署项目,经典化疗药物治疗肿瘤的新理论构建和创新应用,2018.09-2020.08,在研,课题骨干;

7.江苏省科技计划项目(社会发展),儿童急性髓系白血病化疗耐药的新靶点与血浆分子标记物研究,2017.07-2020.06,在研,参与;

8.中国科学院战略性先导科技专项,儿童白血病化疗耐药基因突变和新靶标SETD2的功能研究,2016.01-2017.12,已结题,参与;

9.中国科学院重点部署项目,中国人群精准医学研究计划-恶性肿瘤的基因组演化和精准医学研究,2015.09-2018.12,已结题,参与。

代表论著:

1.Yixin Hu#, Aili Chen#, Xinchang Zheng#, Jun Lu#, Hailong He, Jin Yang, Ya Zhang, Pinpin Sui, Jingyi Yang, Fuhong He, Yi Wang, Peifang Xiao, Xin Liu, Yinmei Zhou, Deqing Pei, Cheng Cheng, Raul C. Ribeiro*, Shaoyan Hu*, Qian-fei Wang*. Ecological Principle Meets Cancer Treatment: Treating Children with Acute Myeloid Leukemia with Low-Dose Chemotherapy. National Science Review, 2019,6(3): 469-479. (共同一作, IF(2018)=13.222, Q1)

2.Aili Chen, Jingyi Yang, Shaoyan Hu*, Qian-fei Wang*. The priming inducton regimen of HAG as a low dose strategy in AML clonal evolution. Science China Life Sciences, 2015, 58(12): 1302-1305. (IF(2018)=3.583, Q1)

3.Xiaofan Zhu#, Fuhong He#, Huimin Zeng#, Shaoping Ling#, Aili Chen#, Yaqin Wang, Xiaomei Yan, Wei Wei, Yakun Pang, Hui Cheng, Chunlan Hua, Yue Zhang, Xuejing Yang, Xin Lu, Lihua Cao, Lingtong Hao, Lili Dong, Wei Zou, Jun Wu, Xia Li, Si Zheng, Jin Yan, Jing Zhou, Lixia Zhang, Shuangli Mi, Xiaojuan Wang, Li Zhang, Yao Zou, Yumei Chen, Zhe Geng, Jianmin Wang, Jianfeng Zhou, Xin Liu, Jianxiang Wang, Weiping Yuan, Gang Huang*, Tao Cheng*, Qian-fei Wang*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature Genetics, 2014, 46(3): 287-293. (共同一作, IF(2018)=25.455, Q1)

4.Xinghui Zhao#, Aili Chen#, Xiaomei Yan, Yue Zhang, Fuhong He, Yoshihiro Hayashi, Yunzhu Dong, Yalan Rao, Bo Li, Rajeana M. Conway, Alba Maiques-Diaz, Shannon E. Elf, Nuomin Huang, Johannes Zuber, Zhijian Xiao, William Tse, Daniel G. Tenen, Qianfei Wang, Wei Chen, James C. Mulloy, Stephen D. Nimer, Gang Huang*. Down-regulation of RUNX1/CBFβ by MLL fusion proteins enhances HSC self-renewal. Blood, 2014, 123(11):1729-1738. (共同一作, IF(2018)=16.562, Q1)

5.Aili Chen, Gang Huang, Epigenetic Technological Applications Chapter20 - Animal Model Study of Epigenetic Inhibitors, Academic Press, 2015. (专著)

6.Yoshihiro Hayashi#, Yue Zhang#, Asumi Yokota#, Xiaomei Yan, Jinqin Liu, Kwangmin Choi, Bing Li, Goro Sashida, Yanyan Peng, Zefeng Xu, Rui Huang, Lulu Zhang, George M. Freudiger, Jingya Wang, Yunzhu Dong, Yile Zhou, Jieyu Wang, Lingyun Wu, Jiachen Bu, Aili Chen, Xinghui Zhao, Xiujuan Sun, Kashish Chetal, Andre Olsson, Miki Watanabe, Lindsey E. Romick-Rosendale, Hironori Harada, Lee-Yung Shih, William Tse, James P. Bridges, Michael A. Caligiuri, Taosheng Huang, Yi Zheng, David P. Witte, Qian-fei Wang, Cheng-Kui Qu, Nathan Salomonis, H. Leighton Grimes, Stephen D. Nimer, Zhijian Xiao*, Gang Huang*. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery. 8(11); 1438–57. (IF(2018)=26.37, Q1)

7.Jiachen Bu, Aili Chen, Xiaomei Yan, Fuhong He, Yunzhu Dong, Yile Zhou, Jianlin He, Di Zhan1, Peipei Lin, Yoshihiro Hayashi, Yanling Sun, Yue Zhang, Zhijian Xiao, H. Leighton Grimes, Qian-fei Wang*, Gang Huang*. SETD2 mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia. 2018, 32(4):890-899. (IF(2018)=9.944, Q1)

8.于雪新, 陈艾莉, 李玥莹,刘丹,王前飞, 白血病的精准基因组医学研究与转化应用. 遗传, 2018. 40(11): p. 988-997.

9.Di Zhan#, Yingchi Zhang#, Peifang Xiao#, Xinchang Zheng, Min Ruan, Jingliao Zhang, Aili Chen, Yao Zou, Yumei Chen, Gang Huang, Shaoyan Hu, Qian-fei Wang*, Xiaofan Zhu*. Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia. Leukemia Research. 2018, 65:20-24. (IF(2018)=2.066, Q3)

10.Jing Zhou#, Jun Wu#, Bo Li#, Dan Liu, Jian Yu, Xiaomei Yan, Si Zheng, Jiguang Wang, Lixia Zhang, Lin Zhang, Fuhong He, Qiang Li, Aili Chen, Yue Zhang, Xinghui Zhao, Yinghui Guan, Xiaohong Zhao, Jin Yan, Jun Ni, Marcelo Nobrega, Bob L?wenberg, Ruud Delwel, Peter J. Valk, Ashish Kumar, Lu Xie, Daniel G. Tenen, Gang Huang*, Qian-fei Wang*. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 2014.01.21, 28(7): 1436~1448. (IF(2018)=9.944, Q1)

11.Yue Zhang, Aili Chen, Xiao-Mei Yan, Gang Huang*. Disordered epigenetic regulation in MLL-related leukemia. International Journal of Hematology. 2012, 96(4): 428-37. (IF(2018)=2.251, Q3)

12.Aili Chen, Yixin Hu, Xinchang Zheng, Jun Lu, Peifang Xiao, Jin Yang, Ya Zhang, Pinpin Sui, Jingyi Yang, Fuhong He, Hailong He, Yi Wang, Chung-I Wu, Xin Liu, Yinmei Zhou, Deqing Pei, Cheng Cheng, Raul C. Ribeiro, Shaoyan Hu and Qianfei Wang. Clinical Outcomes and Mutation Clearance in Children with Acute Myeloid Leukemia Treated with Low-Dose Chemotherapy Plus G-CSF for Remission Induction. 59th American Society of Hematology Annual Meeting, Blood (Abstracts) 2017, 130:1397. Atlanta, United States, 2017.12.9-12.12 (会议论文)

13.Aili Chen, Yixin Hu, Xin Liu, Jun Lu, Peifang Xiao, Xinchang Zheng, Jin Yang, Ya Zhang, Jingyi Yang, Fuhong He, Pinpin Sui, Hailong He, Yi Wang, Cheng Cheng, Raul C. Ribeiro, Shaoyan Hu, Qianfei Wang, Clinical Outcome and Non-Synonymous Mutation Clearance in Chinese Children with Acute Myeloid Leukemia Treated with a Low-Intensity Induction Chemotherapy Regimen, 58th American Society of Hematology Annual Meeting, Blood (Abstracts) 2016, 128:2848, San Diego, United States, 2016.12.3-12.6 (会议论文)

社会任职:
中国研究型医院学会血液病精准诊疗专业委员会青年委员 中国生理学会会员
获奖及荣誉:

2019年 第三届中国血液生理学大会 十佳优秀壁报

2017年 2014年 中国科学院大学 优秀毕业生

2010年 中国科学院研究生院 优秀学生干部

2010年 中国科学院研究生院 三好学生