郭彩霞 ( GUO Caixia )

1999年10月至2001年1月 美国肯塔基大学生理系 博士后2001年1月至2004年 美国德克萨斯州西南医学中心病理系 博士后2004年至2008年 美国德克萨斯州西南医学中心病理系Instructor2008年3月至2009年8月 美国德克萨斯州西南医学中心病理系 助理教授2009年至今 中国科学院北京基因组研究所 研究员

DNA损伤应答与基因组稳定性、核酸代谢与疾病、肿瘤精准医学

在研基金：

1. 国家自然科学基金面上项目, 错配修复蛋白MSH2调控跨损伤DNA合成与疾病发生研究, 2015/01-2018/12, 课题负责人；

2. 国家自然科学基金面上项目, DNA聚合酶eta O-GlcNAc糖基化修饰对其功能的调控研究, 2017/01-2020/12, 课题负责人；

3. 国家自然科学基金重点项目, 非编码RNA及其互作因子表观调控DNA损伤修复研究, 2017/01-2021/12, 课题负责人

近五年发表文章（*代表通讯作者）

1. Huang M, Zhou B, Gong J, Xing L, Ma X, Wang F, Wu W, Shen H, Sun C, Zhu X, Yang Y, Sun Y, Liu Y, Tang TS*, Guo C*. RNA-splicing factor SART3 regulates translesion DNA synthesis. Nucleic Acids Res. (2018). Online.

2. Xie C, Shen H, Zhang H, Yan J, Liu Y, Yao F, Wang X, Cheng Z*, Tang TS*, Guo C*. Quantitative proteomics analysis reveals alterations of lysine acetylation in mouse testis in response to heat shock and X-ray exposure. Biochim Biophys Acta. (2018). 1866(3): 464-472.

3. Sun Z, Zhang H, Wang X, Wang Q, Zhang C, Wang J ,Wang Y, An C, Yang K, Wang Y, Gao F, Guo C*, Tang TS*. TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells. Cell Death Differ. (2018). doi:10.1038/s41418-018-0067-x

4. Zhu, X, Ma X, Tu Y, Huang M, Liu H, Wang F, Gong J, Wang J, Li X, Chen Q, Shen H, Zhu S, Wang Y, Liu Y, Guo C*, Tang TS*. Parkin regulates translesion DNA synthesis in response to UV radiation. Oncotarget. (2017). 8, 36423-36437.

5. Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, Xing L, Zhu X, Zheng H, Fang J, Li X, Wang Q, Wang J, Sun Z, Wang X, Wang Y, Guo C*, Tang TS*. RBM45 competes with HDAC1 for binding to FUS in response to DNA damage. Nucleic Acids Res. (2017).45, 12862–12876.

6. Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS*, Guo C*. Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nat Commun. (2017). 8, 1941.

7. Tu, Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C*, Tang TS*. Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res. (2017).45, 4532-4549.

8. Sun X, Cai X, Yang J, Chen J, Guo C*, Cao P*. Overcomes Imatinib Resistance by Depleting BCR-ABL in Chronic Myeloid Leukemia. Mol Cells. (2016). 39(12):869-876.

9. Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C*, Wang Q*, Tang TS*. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLOS Biol. (2016). 14(11):e2000733.

10. Wang K, Ma X, Zhang X, Wu D, Sun C, Sun Y, Lu X, Wu CI, Guo C*, Ruan J*. Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. Sci Rep. (2016). 6:25310.

11. Sun Y, Yang Y, Shen H, Huang M, Wang Z, Liu Y, Zhang H, Tang TS, Guo C*. iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage. Biochem Biophys Res Commun. (2016). 471(1):142-8.

12. Wang Z, Huang M, Ma X, Li H, Tang T, Guo C*. REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18. J Cell Sci. (2016). 129:1223-1233.

13. Yan J, Zhang H, Liu Y, Zhao F, Zhu S, Xie C, Tang TS, Guo C*. Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice. J Cell Sci. (2016). 129: 492-501.

14. Liu Y, Ma X, Guo C*. Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct. J Biochem. (2015).pii: mvv118.

15. Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin Y, Huang M, Zhang T, Pei H, Chen B, Jansen JG, Wind N, Fischhaber P, Friedberg EC, Tang TS and Guo C*. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. (2015).43, 8325-8339

16. Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J. The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection. Curr Biol. (2014).24(18):2097-110.

17. Wang F, Fischhaber PL, Guo C, Tang TS. Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics. (2014).6(3):287-97.

18. Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo C, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Res. (2014). 24(5):532-41.

19. Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg EC, Yang W, Guo C*. Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct. Proc Natl Acad Sci USA. (2014).111(5): 1789-1794.

20. Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acid Res. (2013).41(22):10312-10322.

21. Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C*, Tang TS*. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Mol Genet. (2013).22(18):3641-3653.

22. Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Jia Y, Qian L, Chen B, Zhang Y, Friedberg C, Tang T and Guo C*. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair. (2013).12(5):377-88.

2016年 中国科学院“朱李月华优秀教师”奖