陈华 ( CHEN Hua )

2015年至今 北京基因组研究所，研究员

2013年-2014年 美国天普大学进化医学研究所，计算遗传学与基因组中心 研究助理教授：

2008年-2012年 哈佛医学院和公共卫生学院，Broad研究所 博士后

本课题组的研究方向是群体遗传学和进化基因组学，侧重于其中的理论与计算方法方面的问题。我们发展新的统计分析方法,同时也会将这些方法应用于分析基因组大数据, 来回答和进化相关的科学问题。

1. Chen H*, Hey J, Chen K. (2015). Inferring Very Recent Population Growth Rate from Population-Scale Sequencing Data: Using a Large-Sample Coalescent Estimator. Molecular Biology and Evolution. 32(11):2996-3011.

2.Chen H.*, Hey J., and Slatkin M. (2015). A hidden Markov model for investigating recent positive selection. Theoretical Population Biology. 99:18-30.

3.Chen H*. (2015). Population genetic studies in the genomic sequencing era. Zoological Research. 36(1): 1-11.

4.Macholdt E., Lede V., Barbieria C., Mpolokab SW., Chen H., Slatkin M., Pakendorfd B., and Stoneking M. (2014). Tracing prehistoric pastoralist migrations: lactase persistence alleles in southern Africa. Current Biology. 24(8): 875-879.

5.López S., García ó., Yurrebaso I., Flores C., Acosta-Herrera M., Chen H., Gardeazabal J., Careaga JM., Boyano MD., Sánchez A., Ratón-Nieto JA., Sevilla A., Smith-Zubiaga I., Galdeano AG., Martinez-Cadenas C., Izagirre N., Rúa C., and Alonso S. (2014). The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population. PloS One. 9(8): e104367.

6.Chen H.* and Chen K. (2013). Asymptotic distributions of coalescence times and ancestral lineage numbers for populations with temporally varying size. Genetics. 194 (3): 721–736.

7.Chen H.* and Slatkin M. (2013). Inferring selection intensity and allele age from multi-locus haplotype structure. Genes, Genomics, Genetics. 3 (8): 1429–1442.

8.Chen H.* (2013). Intercoalescence time distribution of incomplete genealogies in temporally varying populations, and applications in population genetic inference. Annals of Human Genetics. 77 (2): 158-173.

9.Yana K., Wang S., Tan J., Gerbault P., Wark A., Tan L., Yang Y., Li S., Tang K., Chen H., Powell A., Itan Y., Fuller D., Lohmueller J., Mao J., Schachar A., Paymer M., Hostetter E., Byrne E., Burnett E., McMahon AP., Thomas MG., Lieberman DE., Jin L., Tabin CJ., Morgan BA. and Sabeti PC. (2013). Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell. 152 (4): 691-702.

10.Qi X., Cui C., Peng Y., Zhang X., Yang Z., Zhong H., Xiang K, Cao X, Wang Y, Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, Wu T, Chen H, Shi H, and Su B. (2013). Genetic evidence of Paleolithic colonization and Neolithic expansion of modern humans on the Tibetan Plateau. Molecular Biology and Evolution. 30(8):1761-1778.

11.Xiang K., Ouzhuluobu, Peng Y., Yang Z., Zhang X., Cui C., Zhang H., Li M., Zhang Y., Bianba, Gonggalanzi, Basang, Ciwangsangbu, Wu T., Chen H., Shi H., Qi X., and Su B. (2013). Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation. Molecular Biology and Evolution. 30(8):1889-1898.

12.Chen H.* (2012). The joint allele frequency spectrum of multiple populations: A coalescent theory approach. Theoretical Population Biology. 81(2):179-195.

13.Peng Y., Yang Z., Zhang H., Cui C., Qi X., Luo X., Tao X., Wu T., Ouzhuluobu, Basang, Ciwangsangbu, Danzengduohie, Chen H., Shi H., and Su B. (2011). Genetic variations in Tibetan populations and high altitude adaptation at the Himalayas. Molecular Biology Evolution 28(2): 1075-1081.

14.Kosoy R., Ransom RM., Chen H., Marconi M., Macciardi F., Glorioso N., Gregersenm PK., Cusiand D., and Seldin MF. (2011). Evidence for malaria selection of a CR1 haplotype in Sardinia. Genes and Immunity 12: 582-588.

15.Chen H.*, Patterson N. and Reich D*. (2010). Population differentiation as a test for selective sweeps. Genome Research. 20: 393-402.