米双利 ( MI Shuangli )

1. 非编码RNA（microRNA, long-noncoding RNA等）在白血病的发生、发展及耐药机制中的作用；2. 肿瘤细胞的外泌体RNA 分选机制及分子标志物研究，为精准医疗提供临床前转化研究；3. 肠道菌群对代谢性疾病的调节作用。

1. 北京市科技计划项目，基于肠道基因组学的血糖调控健康食品开发，2017-2019，在研，主持

2. 国家自然科学基金重大国际合作研究项目：利用开放科学数据云促进高通量肿瘤基因组研究,2012-2016，在研，主持；

3. 科技部973项目：DNA损伤响应重要蛋白维持基因组稳定性机制研究,2015-2019,在研，课题骨干

4. 科技部973项目：在肺癌微环境中表观遗传修饰对肺癌发展转移的作用机制,2011-2015，在研，课题骨干；

5. 国家自然科学基金面上项目：白血病异常融合蛋白MLL-ENL对小鼠细胞全基因组microRNA的表达调控研,2011-2013，结题，主持；

6. 教育部留学回国人员启动基金，主持。

1. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi HH, Yu X. Lul SY, Chen Y, Xu YZ, Lp Y, Gage FH, Mi SL*, Yao J*. CRISPR interference-based specific and efficient gene inactivation in the brain. Nature Neuroscience. 2018, 21: 447-454.

2. Mertens J, Wang QW, Kim Y, Yu Diana X, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchettto MC, Numberger JI, Calabrese LR, Odegaard KJ, Mccarthy MJ, Zandi PP, Alba M, Bievergelt CM, Mi SL, Brennabd KJ, Kelsoe JR, Gage FH, Yao J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015, 527: 95-99.

3. Zhang J, Li S, Li L, Li M, Guo CY, Yao J, Mi SL*. Exosomal MicroRNA: Trafficking, sorting and function. Genomics Proteomics Bioinformatics. 2015,13(1):17-24.

4. Mi SL, Zhang J, Zhang W, Huang RS. Circulating microRNAs as biomarkers for inflammatory diseases. MicroRNA. 2013, 2(1):64-72.

5. Wang QF, Wu G, Mi SL, He FH, Wu J, Dong JH, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji HK, Thirman MJ. MLL Fusion Proteins Preferentially Regulate a Subset of Wild Type MLL Target Genes in the Leukemic Genome. Blood. 2011, 117: 6895-6905.

6. Wen YJ, Gamazon ER, Bleibel WK, Wing C, Mi SL, McIlwee BE, Delaney SM, Duan SW, Im HK, Dolan ME. An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet. 2012, 21: 1470-1480.

7. Tao Y, Ruan J, Yeh SH, Lu X, Wang Y, Zhai WW, Cai J, Ling SP, Gong Q, Chong ZC, Qu ZZ, Li QQ, Liu J, Yang J, Zheng CH, Zeng CQ, Wang HY, Zhang J, Wang SH, Hao LT, Dong LL, Li WJ, Sun M, Zou W, Yu CX, Li CH, Liu GJ, Jiang L, Xu J, Huang HW, Li CY, Mi SL, Zhang B, Chen BX, Zhao WM, Hu SN, Zhuang SM, Shen Y, Shi SH, Brown C, White KP, Chen DS, Chen PJ, Wu CI. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. P Natl Acad Sci USA. 2011, 108: 12042-12047.

8. Mi SL, Li ZJ, Chen P, He CJ, Cao DL, Elkahloun A, Lu J, Pelloso LA , Wunderlich M, Huang H. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. P Natl Acad Sci USA. 2010, 107: 3710-3715.

9. Hartford CM, Duan SW, Delaney SM, Mi SL, Kistner EO, Lamba JK, Huang RS, Dolan ME. Population Specific Genetic Variants Important in Susceptibility to Cytarabine Arabinoside Cytotoxicity. Blood. 2009, 113: 2145-2153.

10. Duan SW, Mi SL, Zhang W, Dolan ME. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. RNA biology. 2009, 6: 412-425. (* contribute equally)

11. Mi SL, Lu J, Sun M, Li ZJ, Zhang H, Neilly MB, Wang Y, Qian ZJ, Jin J, Zhang YM, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen JJ. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. P Natl Acad Sci USA. 2007, 104: 19971-19976.