雷红星

中国科学院北京基因组研究所

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  • 雷红星
  • 博士生导师
  • 研究员

雷红星 ( Hongxing Lei )

职 称: 研究员
职 务: 博士生导师
E-Mail: leihx(AT)big.ac.cn
学科类别: 生物信息学
学习经历:
1987年9月-1991年6月 华中理工大学 生物医学工程 学士 1998年8月-2003年7月 美国堪萨斯州立大学 生物化学 博士学位 指导教授:Paul E. Smith
工作经历:
1991年7月-1998年7月 军事医学科学院 研究实习员/助理研究员 指导教授:吴加金 2003年8月-2004年8月 美国德拉华大学 博士后 指导教授:段勇 2004年9月-2008年2月 美国加大戴维斯分校 博士后、研究组主管 指导教授:段勇 2008年3月至今 中国科学院北京基因组研究所 研究员
主要研究领域:
计算生物学, 阿尔茨海默病
承担科研项目情况:
1. 科技部973, 2014CB964901, 细胞命运维持与转化的表观遗传调控作用与机制研究, 2014-2018年,在研,课题骨干。 2. 自然科学基金, 30870474, 蛋白质-蛋白质对接的计算模型, 2009-2011年,已结题, 负责人。
代表论著:
1. Jiajia Wang, Xuemei Feng X, Zhouxian Bai, Lee-way Jin, Yong Duan Y, and Hongxing Lei. (2013) Chromosome 19p in Alzheimer’s disease: when genome meets transcriptome. J Alzheimer’s Disease online. 2. Guangchun Han, Jiajia Wang, Fan Zeng, Xuemei Feng X, Jun Yu, Hongyi Cao H, Xu Yi, Huadong Zhou, Lee-way Jin, Yong Duan Y, Yanjiang Wang and Hongxing Lei. (2013) Characteristic transformation of blood transcriptome in Alzheimer’s disease. J Alzheimer’s Disease 35: 373-386. 3. Dapeng Liang, Guangchun Han, Xuemei Feng, Jiya Sun, Yong Duan and Hongxing Lei. Concerted perturbation observed in a hub network in Alzheimer’s disease. PLoS One 2012,7(7): e40498 (corresponding author) 4. Jiya Sun, Xuemei Feng, Dapeng Liang, Yong Duan and Hongxing Lei.Down-regulation of energy metabolism in Alzheimer’s disease is a protective response of neurons to the microenvironment. J Alzheimer’s Disease 2012,28, 389-402 (corresponding author) 5. Hongxing Lei.Amyloid and Alzheimer’s disease. Protein & Cell 2010,1(4),312-314 6. Hongxing Lei, Yao Su, Lian Jin and Yong Duan. The folding network of villin headpiece subdomain. Biophys J 2010,99:3374-3384 (corresponding author) 7. Hongxing Lei, Zhi-Xiang Wang, Chun Wu and Yong Duan. Dual folding pathways of an a/b protein from all-atom ab initio folding simulations. J. Chem. Phys. 2009,131, 165105 8. Hongxing Lei, Chun Wu, Zhi-Xiang Wang, Yaoqi Zhou, and Yong Duan.Folding processes of the B domain of protein A to the native state observed in all-atom ab initio folding simulations. J Chem Phys 2008, 128(23):235105 9. Hongxing Lei, Chun Wu, Haiguang Liu and Yong Duan. Folding free energy landscape of HP35 from molecular dynamics simulations. PNAS, 2007, 104(12): 4925-4930 10. Hongxing Lei and Yong Duan. Two-stage folding of HP-35 from Ab initio simulation. J. Mol. Biol., 2007, 370:196-206 11. Hongxing Lei and Yong Duan. Ab initio folding of albumin binding domain from all-atom molecular dynamics simulation. J Phys Chem B, 2007, 111:5458-5463. 12. Hongxing Lei and Yong Duan. Improved sampling methods for molecular dynamics. Curr Opin Struct Biol, 2007,17:187-191 13. Hongxing Lei; Shubhra G Dastidar and Yong Duan. Folding Transition State and Denatured State Ensembles of FSD-1 from Folding and Unfolding Simulations. J Phys Chem B, 2006, 110:22001-22008 14. Hongxing Lei; Chun Wu; Zhi-Xiang Wang and Yong Duan. Molecular dynamics simulations and free energy analyses on the dimer formation of an amyloidgenic heptamer peptide from human β2-microglobulin: implication to the protofibril structure. J. Mol. Biol., 2006, 356: 1049-1063 15. Chun Wu, Hongxing Lei, and Yong Duan. Elongation of ordered peptide aggregate of an amyloidgenic hexapeptide (NFGAIL) observed in molecular dynamics simulations with explicit solvent. J Am Chem Soc, 2005, 127: 13530-13537 16. Hongxing Lei and Yong Duan. Incorporating intermolecular distance into protein-protein docking. Protein Eng Des Sel, 2004, 17(12): 837-845 17. Hongxing Lei and Yong Duan. The role of plastic β-hairpin and weak hydrophobic core in the stability and unfolding of a full sequence design protein. J Chem Phys 2004, 121(23): 12014-12111 18. Hongxing Lei and Paul E. Smith. The role of the unfolded state in hairpin stability. Biophys J 2003, 85(6): 3513-3520 19. Hongxing Lei and Paul E. Smith. The Effects of Internal Water Molecules on the Structure and Dynamics of Chymotrypsin Inhibitor 2. J Phys Chem B. 2003, 107: 1395-1402 20.Li WuJu, Lei HongXing, Pei WuHong and Wu JiaJin. GeneDn: for high-level expression design of heterologous genes in a prokaryotic system. Bioinformatics, 1998, 14(10): 884-885
社会任职:
Associate Editor,Journal of Alzheimer’s Disease. Associate Editor,Genomics, Proteomics & Bioinformatics.
获奖及荣誉:
1995年,军队科技进步三等奖