吴仲义

中国科学院北京基因组研究所

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  • 吴仲义
  • 博士生导师
  • 研究员

吴仲义 ( WU Chung-I )

职 称: 研究员
职 务: 博士生导师
E-Mail: wuci(AT)big.ac.cn
学科类别: 遗传学 基因组学 生物信息学
学习经历:
1972年-1976年 台湾东海大学 生物学 学士 1977年-1982年 加拿大英属哥伦比亚大学 遗传学 博士
工作经历:

2008年6月至今 中国科学院北京基因组研究所 研究员

2008年6月-2014年5月 中国科学院北京基因组研究所 所长

2004年7月-2008年5月 中山大学 长江学者

1998年7月-2008年5月 芝加哥大学 教授

1998年7月-2006年6月 芝加哥大学生态与进化系 系主任

1991年7月-1998年6月 芝加哥大学 副教授

1990年9月-1991年6月 罗彻斯特大学 副教授

1986年8月-1990年8月 罗彻斯特大学 助理教授

1985年1月-1986年7月 威斯康辛大学麦迪逊分校 博士后

1982年6月-1984年12月 德克萨斯大学休斯顿健康中心 助理研究员

1976年9月-1977年8月 台湾东海大学 助教

主要研究领域:

肿瘤进化和群体遗传学

承担科研项目情况:

1.中国科学院先导专项B类,在模式系统中研究复杂性状演化和稳定性的网络调控,XDB13040300,2014/06-2019/06,共同课题负责人,在研

2.科技部973项目,肿瘤异质性的分子网络研究和新治疗策略,2014CB542006,2014.01-2018.08,首席科学家,在研

3.国家自然科学基金重点项目,MicroRNAs的功能进化分析与全基因组表达稳定性的渠化调控,31130069,2012.01-2016.12,项目负责人,在研

4.中国科学院重点部署项目,肿瘤细胞群体演化及关键突变基因鉴定,KJZD-EW-L06-1,2013.01-2015.12,项目负责人,在研

5.国家自然科学基金重大研究计划项目,指导专家组调研和组织学术交流会费用,91431000,2015.04-2017.03,项目负责人,在研

6.国家自然科学基金重大研究计划项目,指导专家组调研和组织学术交流会费用,91331101,2013.04-2015.03,项目负责人,结题

7.国家自然科学基金重大研究计划项目,指导专家组调研和组织学术交流会费用,91131000,2011.01-2012.12,项目负责人,结题

8.农业部转基因专项,基于micro RNA干涉的转基因新技术的开发与应用,2009ZX08010-017B,2009.06-2011.12,项目负责人,结题

9.中国科学院知识创新工程重大项目课题,癌症基因组和蛋白质组研究,KSCX1-YW-22,2009-2012,结题

代表论著:

(# co-first author, * Corresponding author)

1.Guojing Liu#, Rui Zhang#, Jin Xu, Chung-I Wu* and Xuemei Lu*. Functional conservation of both CDS- and 3’UTR- located miRNA binding sites between species. Molecular biology and evolution, 2015, 32(3): 623-628

2.Yang Lyu, Yang Shen, Heng Li, Yuxin Chen, Li Guo, Yixin Zhao, Eric Hungate, Suhua Shi, Chung-I Wu*, and Tian Tang*. New microRNAs in Drosophila--birth, death and cycles of adaptive evolution. PLoS genetics. 2014; 10, e1004096.

3.Jin Xu#,Rui Zhang#,Yang Shen,Guojing Liu,Xuemei Lu,Chung-I Wu*. The evolution of evolvability in microrna target sites in vertebrates. Genome research. 2013;23:1810-1816

4.Zechen Chong#,Weiwei Zhai#,Chunyan Li,Min Gao,Qiang Gong,Jue Ruan,Juan Li,Lan Jiang,Xuemei Lu,EricHungate,Chung-I Wu*. The evolution of small insertions and deletions in the coding genes of drosophila melanogaster. Molecular biology and evolution. 2013;30:2699-2708

5.Zheng Hu, Yunxin Fu, Anthony J Greenberg, Chung-I Wu*, Weiwei Zhai*. Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis. PLoS genetics. 2013; 9, e1003326.

6.Guodong Wang#, Weiwei Zhai#, HechuangYang, Ruoxi Fan, Xue Cao, Li Zhong, Lu Wang, Fei Liu, Hong Wu, Luguang Cheng, Andrei D. Poyarkov, Nikolai A. Poyarkov JR, Shu-sheng Tang, Wenming Zhao, Yun Gao, Xuemei Lu, David M. Irwin, Peter Savolainen, Chung-I Wu*, Yaping Zhang*. The genomics of selection in dogs and the parallel evolution between dogs and humans. Nature communications. 2013;4:1860-1864

7.Jue Ruan#, Lan Jiang#, Zechen Chong#, Qiang Gong#, Heng Li, Chunyan Li, Yong Tao, Caihong Zheng, Weiwei Zhai, David Turissini, Charles H Cannon, Xuemei Lu*, Chung-I Wu*. Pseudo-sanger sequencing: Massively parallel production of long and near error-free reads using NGS technology. BMC genomics. 2013; 14(1): 711-719

8.Qiang Gong, Yong Tao, Jianrong Yang, Jun Cai, Yunfei Yuan, Jue Ruan, Jin Yang, Huiliang Liu, Wanghua Li, Xuemei Lu, Shimei Zhuang, Sanming Wang, Chung-I Wu*. Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC genomics. 2013;14:51-55

9.Caihong Zheng, Xuexia Miao, Yanen Li, Ying Huang, Jue Ruan, Xi Ma, Li Wang, Chung-I Wu*, and Jun Cai*. Determination of genomic copy number alteration emphasizing a restriction site-based strategy of genome re-sequencing. Bioinformatics. 2013; 29, 2813-2821.

10.Shu Fang, Roman Yukilevich, Ying Chen, David A Turissini, Kai Zeng, Ian A Boussy, and Chung-I Wu*. Incompatibility and competitive exclusion of genomic segments between sibling Drosophila species. PLoS genetics. 2012;8, e1002795.

11.Zecheng Chong#, Jue Ruan# *, and Chung-I Wu*. Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads. Bioinformatics. 2012; 28, 2732-2737.

12.Ziwen He, Xinnian Li, Shaoping Ling, Yunxin Fu, Eric Hungate, Suhua Shi*, Chung-I Wu*. Estimating DNA polymorphism from next generation sequencing data with high error rate by dual sequencing applications. BMC genomics. 2013; 14, 535.

13.Yong Tao#, Jue Ruan#, Shiou-Hwei Yeh#, Xuemei Lu#, Yu Wang#, Weiwei Zhai#, Jun Cai#, Shaoping Ling, Qiang Gong, Zechen Chong, Zhengzhong Qu, Qianqian Li, Jiang Liu, Jin Yang, Caihong Zheng, Changqing Zeng, Hurng-Yi Wang, Jing Zhang, Sheng-Han Wang, Lingtong Hao, Lili Dong, Wenjie Li, Min Sun, Wei Zou, Caixia Yu, Chaohua Li, Guojing Liu, Lan Jiang, Jin Xu, Huanwei Huang, Chunyan Li, Shuangli Mi, Bing Zhang, Baoxian Chen, Wenming Zhao, Songnian Hu, Shi-Mei Zhuang, Yang Shen, Suhua Shi, Christopher Brown, Kevin P.White, Ding-Shinn Chen*, Pei-Jer Chen, Chung-I Wu*. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci USA. 2011;108:12042-12047

14.Renchao Zhou#, Shaoping Ling#, Wenming Zhao#, Naoki Osada, Sufang Chen, Meng Zhang, Ziwen He, Hua Bao, Cairong Zhong, Bing Zhang, Xuemei Lu, David Turissini, Norman C. Duke, Jian Lu*, Suhua Shi*, Chung-I Wu*. Population genetics in nonmodel organisms: Ii. Natural selection in marginal habitats revealed by deep sequencing on dual platforms. Molecular biology and evolution. 2011; 28(10): 2833-2842

15.Yang Shen, Yang Lv, Lei Huang, Wensheng Liu, Ming Wen, Tian Tang, Rui Zhang, Eric Hungate, Suhua Shi*, Chung-I Wu*. Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. Proc Natl Acad Sci USA. 2011;108, 15942-15947.

16.Ziwen He#, Weiwei Zhai#, Haijun Wen#, Tian Tang, Yu Wang, Xuemei Lu, Anthony J. Greenberg, Richard R. Hudson, Chung-I Wu*, Suhua Shi*. Two evolutionary histories in the genome of rice: The roles of domestication genes. PLoS genetics. 2011; 7(6): 1-3

17.Xuemei Lu, Chung-I Wu*. Sex, sex chromosomes and gene expression. BMC biology. 2011;9:30-32

18.Xuemei Lu#, Joshua A. Shapiro#, Chau-Ti Ting, Yan Li, Chunyan Li, Jin Xu, Huanwei Huang, Ya-Jen Cheng, Anthony J. Greenberg, Shou-Hsien Li, Mao-Lien Wu, Yang Shen, Chung-I Wu*. Genome-wide misexpression of x-linked versus autosomal genes associated with hybrid male sterility. Genome research. 2010; 20(8): 1097-1102

19.Tian Tang#, Supriya Kumar#, Yang Shen, Jian Lu, Maolien Wu, Suhua Shi, Wen-Hsiung Li*, Chung-I Wu*. Adverse interactions between micro-RNAs and target genes from different species. Proc Natl Acad Sci USA. 2010;107, 12935-12940.

20.Guodong Wang#, Ruoxi Fan#,Weiwei Zhai, Fei Liu, Lu Wang, Li Zhong, Hong Wu, Hechuan Yang, Shifang Wu,Chunling Zhu, ,Yan Li, Yun Gao, Rili Ge, Chung-I Wu, Yaping Zhang*. Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau. Genome biology and evolution. 2014; 6, 2122-2128.

21.Shanye Yin#, Jing Yang#, Bin Lin#, Wenjun Deng#, Yuchao Zhang, Xianfu Yi,Yufang Shi, Yong Tao, Jun Cai, Chung-I Wu, Guoping Zhao, Laurence D Hurst, Jie Zhang, Landian Hu*, Xiangyin Kong*. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Scientific reports. 2014; 4, 6036.

22.Lan Jiang#, Jing Zhang#, Jing-Jing Wang#, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang,Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 153, 773-84, (Cover story,highlighted by Cell, Nature Review Genetics, etc.)

专利:

1.李春燕,杨芳,刘稳升,王瑜,吕雪梅,吴仲义,用于恶性肿瘤治疗的组合物及其应用,中国,201210046682.0 专利

2.李春燕,董恩成,刘珍珍,吕雪梅,吴仲义,筛选肿瘤早期诊断靶标的Small RNA-Seq库的构建方法,中国,201210041472.2 专利

社会任职:
NCBI: Member of Adviser Board NCBI: Scientific Cousellor 加利福尼亚大学旧金山分校Center of Evolution and Cancer: Ajunct Professor 芝加哥大学 Institute of Genomics and system biology: Senior Fellow
获奖及荣誉:

1990-1995年获得NIH研究职业发展奖

1989-1991获得全国唐氏综合症协会奖

2004年获得台湾东海大学优秀毕业生奖

2004年被评为中研院院士

2011年 国家自然科学奖 二等奖

2013年度、2014年度中国科学院“优秀研究生指导教师”奖