孙宝发

中国科学院北京基因组研究所

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  • 孙宝发
  • 硕士生导师
  • 研究员

孙宝发 ( SUN Baofa )

职 称: 副研究员
职 务: 硕士生导师
E-Mail: sunbf@big.ac.cn
学科类别: 遗传学,生物信息学
学习经历:
2009年9月-2013年1月 中国科学院动物研究所 动物学专业 理科博士学位 2006年9月-2009年7月 汕头大学 生物化学与分子生物学专业 理科硕士学位 2002年9月-2006年7月 湖南科技大学 生物科学专业 理科学士学位
工作经历:

2016年1月至今 中国科学院北京基因组研究所 副研究员

2013年7月-2016年1月 中国科学院北京基因组研究所 助理研究员

主要研究领域:

1. 各种RNA甲基化的分布特征及规律

2. RNA甲基化对RNA加工代谢的调控

3. RNA甲基化对多种生物学过程及疾病发生的调控机制

承担科研项目情况:

1. 国家基金委青年科学基金项目,RNA m6A甲基化修饰调控mRNA选择性剪接机制研究,2015.01-2017.12,结题,主持;

2. 国家基金委面上项目,m5C 调控 mRNA 翻译的功能研究, 2017.01-2020.12,在研,主持;

3. 中国科学院人才项目,2016级青年创新促进会,2016.01-2019.12,在研,主持;

4. 国家基金委重大研究计划,可逆化学修饰调控 lncRNA二级结构机制及其功能研究,2018.01-2021.12,在研,参加;

5. 国家基金委重点项目,RNA m6A 修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究,2015.01-2019.12,在研,参加;

6. 国家基金委面上项目,mRNA甲基化调控儿童TEL/AML1阳性急性淋巴细胞白血病发生发展机制研究,2015.01-2018.12,在研,参加

代表论著:

[1] Shiming Peng#, Wen Xiao#, Dapeng Ju#, Baofa Sun#, Nannan Hou, Qianlan Liu, Yanli Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, Ran Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, Tao Cai, Yong-Liang Zhao, Fengchao Wang, Yongzhan Nie, Gang Zhi, Yun-Gui Yang*, Eric Erquan Zhang*, Niu Huang*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Science Translational Medicine 11(488): eaau7116 (2019) [2] Rong Wu#, Ang Li#, Baofa Sun#, Jian-Guang Sun#, Jinhua Zhang#, Ting Zhang#, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao,Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang*, Yun-Gui Yang*, Zengqiang Yuan*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research 29(1): 23-41 (2019) [3] Xin Tian#, Baofa Sun#, Chuanyuan Chen#, Chunchun Gao#, Ji Zhang#, Xingyu Lu#, Linchen Wang, Xiangnan Li, Yurong Xing, Ruijuan Liu, Xiao Han, Zheng Qi, Xiaojian Zhang, Chuan He, Dali Han*, Yun-Gui Yang*, and Quancheng Kan*. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer. Cell Research 28(5): 597-600 (2018). [4] Chunxia Zhang#, Yusheng Chen#, Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Wen Xiao, Yun-Gui Yang*, and Feng Liu*. m6A modulates haematopoietic stem and progenitor cell specification in vertebrates. Nature 549(7671):273-276 (2017). (Highlighted in J Genet Genomics and Sci Signal.) [5] Xin Yang#, Ying Yang#, Bao-Fa Sun#, Yu-Sheng Chen#, Jia-Wei Xu#, Wei-Yi Lai#, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang*, Ying-Pu Sun*, Yun-Gui Yang*. 5-methylcytosinepromotes mRNA export- NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res. 27(5):606-625 (2017). (Cell Res封面故事,入选Cell Res和Nat Sci Rev研究特色论文评论和F1000) [6] Kai Xu#, Ying Yang#, Gui-Hai Feng#, Bao-Fa Sun#, Jun-Qing Chen#, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou*, Yun-Gui Yang*, Wei Li*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Res. 27(9):1100-1114 (2017). (Cell Res封面故事) [7] Ang Li#, Yu-Sheng Chen#, Xiao-Li Ping, Xin Yang, Wen Xiao, Ying Yang, Hui-Ying Sun, Qin Zhu, Poonam Baidya, Xing Wang, Devi Prasad Bhattarai, Yong-Liang Zhao, Bao-Fa Sun*, Yun-Gui Yang*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Res. 27(3):444-447 (2017). [8] Wen Xiao#, Samir Adhikari#, Ujwal Dahal#, Yu-Sheng Chen#, Ya-Juan Hao#, Bao-Fa Sun#, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Hai-Li Ma, Chun-Min Huang, Ying Yang, Niu Huang, Gui-Bin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang*. Nuclear m6A reader YTHDC1 regulates mRNA splicing. Mol Cell 61(4):507-519 (2016). [9] Ying Yang#, Bao-Fa Sun#, Wen Xiao, Xin Yang, Hui-Ying Sun, Yong-Liang Zhao, Yun-Gui Yang*. Dynamic m6A modification and its emerging regulatory role in mRNA splicing. Sci Bull 60(1):21-32 (2015). [10] Tangliang Li, Yue Shi, Pei Wang, Luis Miguel Guachalla, Baofa Sun, Tjard Joerss, Yu-Sheng Chen, Marco Groth, Anja Krueger, Matthias Platzer, Yun-Gui Yang, Karl Lenhard Rudolph, Zhao-Qi Wang*. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J 34(12):1630-1647 (2015). [11] Xiao-Li Ping#, Bao-Fa Sun#, Lu Wang#, Wen Xiao#, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu*, and Yun-Gui Yang*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res 24(2):177–189 (2014). (Natl Sci Rev研究特色论文) [12] Xu Zhao#, Ying Yang#, Bao-Fa Sun#, Yue Shi#, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Gui-Fang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, and Yun-Gui Yang*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res 24(12): 1403-1419 (2014). (Cell Res研究特色论文) [13] Bailin Zhao #, Ying Yang #, Xiaoli Wang#, Zechen Chong, Ruichuan Yin, Shu-Hui Song, Chao Zhao, Cuiping Li, Hua Huang, Bao-Fa Sun, Danni Wu, Kang-Xuan Jin, Maoyong Song, Ben-Zhan Zhu, Guibin Jiang, Jannie M. Rendtlew Danielsen, Guo-Liang Xu, Yun-Gui Yang*, Hailin Wang*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res 42(3):1593-1605 (2014). [14] Xu Zhao#, Ying Yang#, Bao-Fa Sun, Yong-Liang Zhao, Yun-Gui Yang*. FTO and obesity: mechanisms of association. Curr Diabetes Rep 14(5):486 (2014).

社会任职:
获奖及荣誉:

2016年 2016级中国科学院青年创新促进会会员