刘 江 ( LIU Jiang )

生命科学中有一个非常基本的科学问题是我们如何从一个受精卵如何发育成一个个体。在此过程中表观信息的调控起着非常重要的作用。然而对表观遗传信息如何跨代遗传、如何与基因组共进化以及如何影响物种进化，目前却对其了解有限。课题组将揭示不同的表观遗传修饰如DNA甲基化、组蛋白修饰以及染色体空间结构在不同进化等级的动物中的遗传规律及进化规律；阐明各种表观遗传信息如何协同作用指导动物的生殖发育；进而探索DNA序列进化和表观遗传信息进化如何相互推动的关系，阐明表观遗传信息对物种进化的推动作用。对表观遗传修饰如何从父母遗传到子代的遗传和进化规律进行研究。

已取得的科学成果：使用斑马鱼(Cell, 2013)和哺乳动物(Cell, 2014)为模型，揭示了子代甲基化图谱继承和重编程的规律。成果首次证明除了DNA被遗传外，表观遗传信息也可以完整的遗传到子代中去。近期揭示染色体3D高级结构在配子中的特殊状态以及如何在胚胎发育过程中变化而影响胚胎的发育（Cell，2017）。还使用生物信息学方法，发现SPOP是肾癌的分子探针(Science, 2009)，揭示SPOP在肾癌产生和发展过程中起核心作用(Cancer Cell, 2014), 近期确定SPOP是肾癌的药物靶标(Cancer Cell, 2016)。

* Corresponding author

1. Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, and Jiang Liu*.Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell, 2018, 173, 248-259

2. Yuwen Ke, Yanan Xu, Xuepeng Chen, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Xie Wei, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis, Cell, 2017;170(2):367-381

3. Guoqiang Li, Yang Yu, Yong Fan, Congru Li, Xiaocui Xu, Jialei Duan,Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian,Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu,Jie Qiao*, Jiang Liu*,Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. Journal of Genetics and Genomics, 2017,44 475e481

4. Zhong-Qiang Guo, Tong Zheng, Baoen Chen, Cheng Luo, Sisheng Ouyang, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang*, JiangLiu*, and Hualiang Jiang*. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer, Cancer Cell, 2016, 30, 474–484 (IF: 27, highlighted by Nature Reviews Urology)

5. Ke Chen, Jing Zhang, Zhongqiang Guo, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou, Jiang Liu* and Weimin Ci*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, Jan;26(1):103-18

6. Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu*, Kevin P. White*, SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Cancer Cell, 2014,25, 455-468,

7. Lu Wang, Jun Zhang, Jialei Duan, Xinxing Gao, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu*，Programming and inheritance of parental DNA methylomes in mammals，Cell, 2014, 157(4),979-991

8. Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 153, 773-84, (Cover story， highlighted by Cell, Nature Review Genetics）

9. Jiang Liu, Murad Ghanim, Lei Xue, Ivan Iossifov, Cesar Angeletti, Sujun Hua, Nicolas Negre, Michael Ludwig, Thomas Stricker, Hikmat A. Al-Ahmadie, Maria Tretiakova, Robert L. Camp, Montse Perera-Alberto, David L. Rimm, Tian Xu, Andrey Rzhetsky and Kevin P. White. 2009. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer, Science, 323(5918):1218-1222

1. 中青年科技创新领军人才，国家科技部，2013 2. 中国科学院青年科学家奖，中国科学院，20143. 杰出青年基金获得者，国家自然科学基金委员会，2014 4. 朱李月华导师奖，中国科学院，2014 5. 李汝祺动物遗传奖，中国遗传学会，2015 6. 中国科学院优秀导师奖，中国科学院，2015 7. TWAS Young affiliate 8. 万人计划，领军人才，中组部，2016