吴燕

中国科学院北京生命科学研究院

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  • 吴燕
  • 副研究员
  • 北京市朝阳区北辰西路1号院5号,100101
简历:

博士,副研究员,2017年10月起任中国科学院北京生命科学研究院副研究员。主持国家自然科学基金青年基金1项。2016年入选中国科学院青年创新促进会会员。

研究领域:

1.流感病毒神经氨酸酶NA与抑制剂互作的分子机制、耐药机制及新型抑制剂研究。

2.布尼亚病毒表面蛋白的分子特性研究。

3.布尼亚病毒疫苗与抗体药物研究。

代表论著:
Yan Wu#, Yaohua Zhu#, Feng Gao#,*, Yongjun Jiao#, Babayemi Oladejo, Yan Chai, Yuhai Bi, Shan Lu, Mengqiu Dong, Chang Zhang, Guangmei Huang, Gary Wong, Na Li, Yanfang Zhang, Yan Li, Wenhai Feng, Yi Shi, Mifang Liang, Rongguang Zhang, Jianxun Qi, George F. Gao*, 2017, Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope. Proceedings of the National Academy of Sciences of the United States of America, 114 (36): E7564-E7573.Yaohua Zhu#, Yan Wu#, Yan Chai, Jianxun Qi, Ruchao Peng, Wenhai Feng*, George F. Gao*, 2017, The postfusion structure of the Heartland virus Gc glycoprotein supports taxonomic separation of the bunyaviral families Phenuiviridae and Hantaviridae. Journal of Virology, 92 (1): e01558-17. Yan Wu, Feng Gao, Jianxun Qi, Yuhai, Bi, Lifeng Fu, Sankar Mohan, Yuhang Chen, Xuebing Li, B. Mario, Pinto, Christopher J Vavricka, Po Tien, George F. Gao*, 2016. Resistance to mutant group-2 influenza neuraminidases of an oseltamivir-zanamivir hybrid inhibitor. Journal of Virology, 90 (23): 10693-10700.Lifeng Fu#, Yuhai Bi#, Yan Wu#, Shanshan Zhang, Jianxun Qi, Yan Li, Xuancheng Lu, Zhenning Zhang, Xun Lv, Jinghua Yan, George F. Gao*, Xuebing Li*. 2016. Structure-based tetravalent Zanamivir with potent inhibitory activity against drug-resistant influenza viruses. Journal of Medicinal Chemistry, 59 (13): 6303-12.Yan Wu#, Yuhai Bi#, Christopher J Vavricka#, Xiaoman Sun, Yanfang Zhang, Feng Gao, Min Zhao, Haixia Xiao, Chengfeng Qin, Jianhua He, Wenjun Liu, Jinghua Yan, Jianxun Qi, George F Gao*. 2013. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research, 23(12):1347-1355. (With front cover) Yan Wu#, Guangrong Qin#, Feng Gao, Yue Liu, Christopher J. Vavricka, Jianxun Qi, Hualiang Jiang, Kunqian Yu, George F. Gao*. 2013, Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding. Scientific Reports, 3: 1551-1558.Christopher J. Vavricka#, Qing Li#, Yan Wu#, Jianxun Qi, Mingyang Wang, Yue Liu, Feng Gao, Jun Liu, Enguang Feng, Jianhua He, Jinfang Wang, Hong Liu, Hualiang Jiang, George F. Gao*. 2011. Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group specific Mechanisms for Influenza NA Inhibition. PLoS Pathogens, 7: e1002249. Yan Wu, Feng Gao, Jun Liu, Jianxun Qi, Emma Gostick, David A. Price, George F.Gao*. 2011. Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insight into immune protection from SIV. The Journal of Immunology, 187:6382-6392. (With front cover)

(#共享第一作者)