刘凡

中国科学院北京基因组研究所

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  • 刘凡
  • 博士生导师
  • 研究员

刘凡 ( LIU Fan )

职 称: 研究员
职 务: 博士生导师
E-Mail: liufan@big.ac.cn
学科类别: 基因组学,遗传学
学习经历:
1994年9月-1999年7月 山东大学 临床医学专业 医学学士学位; 2002年9月-2003年7月 荷兰Erasmus大学 遗传流行病专业 硕士学位; 2003年9月-2004年7月 荷兰Erasmus大学 遗传流行病专业 理学博士学位; 2004年9月-2009年2月 荷兰Erasmus大学 遗传流行病专业 博士学位。
工作经历:

2015年3月至今 中国科学院北京基因组研究所 研究员 博士生导师;

2013年1月-2015年3月 荷兰Erasmus大学医学中心 助理教授,博士生导师;

2009年2月-2012年12月 荷兰Erasmus大学医学中心 博士后;

2004年9月-2009年2月 荷兰Erasmus大学医学中心 博士研究生。

主要研究领域:

解释人类复杂性状和疾病的遗传力并鉴定相关的遗传因子;基因组大数据分析方法的创新;建立通过基因型预测人类性状和疾病的数学模型;确定基因型和人类外部表达性状的关系及其在法医学中进行应用。

承担科研项目情况:

1.Erasmus University Fellowship,Approaching “missing heritability”by heterozygous loss-of-function alleles,2012-2014,结题,主持人;

2.NFI & NWO,Predicting human externally visible traits from DNA variants,2002-2008,结题,学术骨干,相关专利US2011312534 A1 20111222 METHOD FOR PREDICTION OF HUMAN IRIS COLOR,WO2011107973 A2 20110909 METHOD FOR PREDICTION OF HUMAN IRIS COLOR;

3.Unilever & NWO,Genetics of skin aging,2013-2015,在研,主要负责人;

4.ERUROFORGEN,Predicting hair structure from DNA for investigative purposes,2014-2016,在研,主要负责人;

5.NWO,Methodological approaches to study the genetics of dementia and cognitive function,2004-2009,结题,主要负责人。

代表论著:

1. Jacobs LC, Hamer MA, Gunn DA, Deelen J, Lall JS, van Heemst D, Uh HW, Hofman A, Uitterlinden AG, Griffiths CE, Beekman M, Eline Slagboom P, Kayser M, Liu F, Nijsten T (2015) A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots. J Invest Dermatol.

2. Jacobs LC, Liu F, Pardo LM, Hofman A, Uitterlinden AG, Kayser M, Nijsten T (2015) IRF4, MC1R, and TYR genes are risk factors for actinic keratosis independent of skin color. Hum Mol Genet.

3. Jacobs LC, Liu F, Bleyen I, Gunn DA, Hofman A, Klaver CCW, Uitterlinden AG, Neumann HAM, Bataille V, Spector TD, Kayser M, Nijsten T (2014) Intrinsic and Extrinsic Risk Factors for Sagging Eyelids. JAMA Dermatol 150: 836-43.

4. Lao O, Liu F, Wollstein A, Kayser M (2014) GAGA: A New Algorithm for Genomic Inference of Geographic Ancestry Reveals Fine Level Population Substructure in Europeans. PLoS Comput Biol 10: e1003480.

5. Liebrechts-Akkerman G, Liu F, Lao O, Ooms AHAG, van Duijn K, Vermeulen M, Jaddoe VW, Hofman A, Engelberts AC, Kayser M (2014) PHOX2B polyalanine repeat length is associated with sudden infant death syndrome and unclassified sudden infant death in the Dutch population. Int J Legal Med 128: 621-9.

6. Liu F*, Walsh S, Kayser M (2014) Of sex and IrisPlex eye colour prediction: A reply to Martinez-Cadenas et al. Forensic Sci Int Genet 9: e5-e6.

7. Liu F, Hendriks AEJ, Ralf A, Boot AM, Benyi E, S?vendahl L, Oostra BA, van Duijn C, Hofman A, Rivadeneira F, Uitterlinden AG, Drop SLS, Kayser M (2013) Common DNA variants predict tall stature in Europeans. Hum Genet 133: 587-97.

8. Liu F*, Wen B, Kayser M (2013) Colorful DNA polymorphisms in humans. Semin Cell Dev Biol 24: 562-75.

9. Walsh S, Liu F, Wollstein A, Kovatsi L, Ralf A, Kosiniak-Kamysz A, Branicki W, Kayser M (2013) The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA. Forensic Sci Int Genet 7: 98-115.

10. Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F* (2012) Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans. Hum Genet 132: 147-58.

11. Liu F, van der Lijn F, Schurmann C, Zhu G, Chakravarty MM, Hysi PG, Wollstein A, Lao O, de Bruijne M, Ikram MA, van der Lugt A, Rivadeneira F, Uitterlinden AG, Hofman A, Niessen WJ, Homuth G, de Zubicaray G, McMahon KL, Thompson PM, Daboul A, Puls R, Hegenscheid K, Bevan L, Pausova Z, Medland SE, Montgomery GW, Wright MJ, Wicking C, Boehringer S, Spector TD, Paus T, Martin NG, Biffar R, Kayser M, VisiGen IVTG (2012) A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLoS Genet 8: e1002932.

12. Branicki W, Liu F, van Duijn K, Draus-Barini J, Pospiech E, Walsh S, Kupiec T, Wojas-Pelc A, Kayser M (2011) Model-based prediction of human hair color using DNA variants. Hum Genet 129: 443-54.

13. Liu F*, Struchalin MV, van Duijn K, Hofman A, Uitterlinden AG, van Duijn C, Aulchenko YS, Kayser M (2011) Detecting Low Frequent Loss-of-Function Alleles in Genome Wide Association Studies with Red Hair Color as Example. PLoS One 6: e28145.

14. Walsh S, Liu F, Ballantyne KN, van Oven M, Lao O, Kayser M (2011) IrisPlex: A sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information. Forensic Sci Int Genet 5: 170-80.

15. Liu F, Pardo LM, Schuur M, Sanchez-Juan P, Isaacs A, Sleegers K, de Koning I, Zorkoltseva IV, Axenovich TI, Witteman JCM, Janssens ACJW, van Swieten JC, Aulchenko YS, Oostra BA, van Duijn CM (2010) The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiol Aging 31: 1831-3.

16. Liu F, Wollstein A, Hysi PG, Ankra-Badu GA, Spector TD, Park D, Zhu G, Larsson M, Duffy DL, Montgomery GW, Mackey DA, Walsh S, Lao O, Hofman A, Rivadeneira F, Vingerling JR, Uitterlinden AG, Martin NG, Hammond CJ, Kayser M (2010) Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci. PLoS Genet 6: e1000934.

17. Zubakov D, Liu F, van Zelm MC, Vermeulen J, Oostra BA, van Duijn CM, Driessen GJ, van Dongen JJ, Kayser M, Langerak AW (2010) Estimating human age from T-cell DNA rearrangements. Curr Biol 20: R970-1.

18. Liu F, Ikram MA, Janssens ACJW, Schuur M, de Koning I, Isaacs A, Struchalin M, Uitterlinden AG, den Dunnen JT, Sleegers K, Bettens K, Van Broeckhoven C, van Swieten J, Hofman A, Oostra BA, Aulchenko YS, Breteler MMB, van Duijn CM (2009) A Study of the SORL1 Gene in Alzheimer's Disease and Cognitive Function. J Alzheimers Dis 18: 51-64.

19. Liu F, van Duijn K, Vingerling JR, Hofman A, Uitterlinden AG, Janssens ACJW, Kayser M (2009) Eye color and the prediction of complex phenotypes from genotypes. Curr Biol 19: R192-R3.

20. Hoppenbrouwers IA, Liu F, Aulchenko YS, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ (2008) Maternal transmission of multiple sclerosis in a Dutch population. Arch Neurol 65: 345-8.

21. Kayser M, Liu F, Janssens ACJW, Rivadeneira F, Lao O, van Duijn K, Vermeulen M, Arp P, Jhamai MM, van Ijcken WFJ, den Dunnen JT, Heath S, Zelenika D, Despriet DDG, Klaver CCW, Vingerling JR, de Jong PTVM, Hofman A, Aulchenko YS, Uitterlinden AG, Oostra BA, van Duijn CM (2008) Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene. Am J Hum Genet 82: 411-23.

22. Liu F, Kirichenko A, Axenovich TI, van Duijn CM, Aulchenko YS (2008) An approach for cutting large and complex pedigrees for linkage analysis. Eur J Hum Genet 16: 854-60.

23. González-Zuloeta Ladd AM, Liu F, Houben MPWA, Arias Vásquez A, Siemes C, Janssens ACJW, Coebergh JWW, Hofman A, Janssen JAMJL, Stricker BHC, van Duijn CM (2007) IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. Eur J Cancer 43: 1718-22.

24. Liu F, Arias-Vasquez A, Sleegers K, Aulchenko YS, Kayser M, Sanchez-Juan P, Feng BJ, Bertoli-Avella AM, van Swieten J, Axenovich TI, Heutink P, van Broeckhoven C, Oostra BA, van Duijn CM (2007) A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. Am J Hum Genet 81: 17-31.

25. Liu F, Elefante S, van Duijn CM, Aulchenko YS (2006) Ignoring distant genealogic loops leads to false-positives in homozygosity mapping. Ann Hum Genet 70: 965-70.

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