韩大力 ( HAN Dali )

2017年至今 中国科学院北京基因组研究所 研究员 博士生导师 2012年12月-2017年 芝加哥大学 博士后学者

新型核酸修饰测序组学，肿瘤表观组学，生物信息学

实验室主页

1. 国家自然基金应急项目，DNA 5hmC和5fC调控胚胎发育机制研究，2018/01-2018/12,在研，主持；

2. 中国科学院A类战略性先导科技专项，核酸新型修饰调控器官再生机制研究，2017/12-2022/11,在研，子课题负责人；

1. Tongnian Gu#, Siqi Zhao#, Yishuang Pia, Weizhong Chena, Chuanyuan Chenb,c, Qian Liud, Min Lid, Dali Han *, and Quanjiang Ji* .Highly Efficient Base Editing in Staphylococcus aureus Using an Engineered CRISPR RNA-guided Cytidine Deaminase. Chemical Science (2018 Accepted, DIO: 10.1039/C8SC00637G. http://pubs.rsc.org/en/Content/ArticleLanding/2018/SC/C8SC00637G#! divAbstract)

2. Xin Tian#, Baofa Sun#, Chuanyuan Chen#, Chunchun Gao#, Ji Zhang#, Xingyu Lu#, Linchen Wang, Xiangnan Li, Yurong Xing, Ruijuan Liu, Xiao Han, Zheng Qi, Xiaojian Zhang, Chuan He, Dali Han*, Yun-Gui Yang*, Quancheng Kan*. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer. Cell Research. (2018 Accepted, DIO: 10.1038/s41422-018-0014-x, https://www.ncbi.nlm.nih.gov/pubmed/?term=29467383)

3. Qing Dai*, Sharon Moshitch-Moshkovitz*, Dali Han*, Nitzan Kol, Ninette Amariglio, Gideon Rechavi, Dan Dominissini, Chuan He. Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nature Methods. 2017, 14: 695-698.

4. Dali Han*, Xingyu Lu*, Alan H. Shih*, Ji Nie, Qiancheng You, Meng Michelle Xu, Ari M. Melnick, Ross L. Levine, Chuan He. A highly sensitive and robust method for genome-wide 5hmC profiling of rare cell populations. Molecular Cell. 2016, 63, 711–719

5. Bo Xia*, Dali Han*, Xingyu Lu*, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin, Hu Zeng, Menghao Liu, Xiang Jiang, Wei Xie, Chuan He, Chengqi Yi. Bisulfite-free, Base-resolution analysis of 5-formylcytosine at the genome scale. Nature Methods 2015, 12, 1047-1050

6. Xingyu Lu*, Dali Han*, Zhao Boxuan Simen*, ChunXiao Song, LiSheng Zhang, Louis C Doré, Chuan He. Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. Cell Research 2015, 25, 386-389

7. Ming Su*, Dali Han*, Jerome BoydKirkup, Xiaoming Yu, JingDong J Han. Evolution of Alu Elements toward Enhancers. Cell Reports 2014, 7, 376-385

8. Yixing Han*, Dali Han*, Zheng Yan, Jerome D BoydKirkup, Christopher D Green, Philipp Khaitovich, JingDong J Han. Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain. Aging cell 2012, 11, 1055-1064

9. Yi Liu*, Dali Han*, Yixing Han*, Zheng Yan, Bin Xie, Jing Li, Nan Qiao, Haiyang Hu, Philipp Khaitovich, Yuan Gao, JingDong J Han. Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq. Nucleic Acids Research 2011, 39, 1408-1418