李茹姣

中国科学院北京基因组研究所

浏览次数

24

收藏次数

0

接洽次数

0

  • 李茹姣
  • 硕士生导师
  • 研究员

李茹姣 ( LI Rujiao )

职 称: 高级工程师
职 务: 硕士生导师
E-Mail: lirj@big.ac.cn
学科类别: 基因组学,生物信息学
学习经历:
2000年—2005年 吉林大学理论与计算化学国家重点实验室 博士 1996年—2000年 吉林大学化学系 本科
工作经历:

2010年至今 中国科学院北京基因组研究所 高级工程师 硕士生导师

2009年—2010年 中国科学院北京基因组研究所 高级工程师

2008年—2009年 中国科学院北京基因组研究所 助理研究员

2005年—2007年 北京宏剑公司 技术副总

主要研究领域:

DNA和RNA表观修饰研究

承担科研项目情况:

1. 国家重点研发计划“精准医学研究”重点专项 “中国重大疾病与罕见病临床与生命组学数据库”项目 2017.07-2020.12 骨干; 2. 中国科学院战略先导专项, 动物复杂性状多组学数据的存贮与访问平台建设, 2014.06-2019.12, 骨干; 3. 国家自然科学基金,基于第二代测序技术的DNA甲基化数据挖掘分析新方法的研究及网络服务器的搭建, 2011.01-2013.12, 主持; 4. 所创新青年基金 全基因组研究DNA甲基化在水稻种子萌发过程中的变化及启动子区甲基化状况的变化对基因转录调控的影响,2011.01-2012.12,主持。

代表论著:

1. Rujiao Li*, Fang Liang, Mengwei Li, Dong Zou, Shixiang Sun, Yongbing Zhao, Wenming Zhao, Yiming Bao, Jingfa Xiao, Zhang Zhang*, MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res,2017 Nov 17. doi: 10.1093/nar/gkx1139.

2. BIG Data Center Members, Database Resources of the BIG Data Center in 2018. Nucleic Acids Res, 2017 Oct 3. doi: 10.1093/nar/gkx897. (共同第一作者)

3. Yue Pan, Fang Liang, Rujiao Li, Wei Qian, MarR-Family Transcription Factor HpaR Controls Expression of the vgrR-vgrS Operon of Xanthomonas campestris pv. campestris. Mol Plant Microbe Interact. 2017 Oct 27. doi: 10.1094/MPMI-07-17-0187-R.

4. BIG Data Center Members, The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res, 2017, 45(D1), D18-24. (共同第一作者)

5. Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge, Fang Liang, Xin Sheng, Wenwen Dai, Meili Chen, Jiayan Wu, Jingfa Xiao, Weiheng Su, Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC Genomics, 2017, 18(suppl 1), 933. (共同第一作者)

6. Baoyu Peng, Yue Pan, Rujiao Li, Jinwei Wei, Fang Liang, Li Wang, Fangfang Wang, An Essential Regulatory System Originating from Polygenic Transcriptional Rewiring of PhoP-PhoQ of Xanthomonas campestris. Genetics. 2017, 206(4), 2207-23. (共同第一作者)

7. Qing Liu, Guocheng Liu, Ting Wang, Jing Fu, Rujiao Li, Linlin Song, Zhengang Wang, Baoquan Ding, Fei Chen, Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base Pairs. Chemphyschem, 2017, 18(21), 2977-80.

8. Lina Yuan, Yang Yu, Yanmin Zhu, Yulai Li, Changqing Li, Rujiao Li, Qin Ma, Gilman Kit-Hang Siu, Jun Yu, Taijiao Jiang, Jingfa Xiao, Yu Kang, GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes. BMC Genomics, 2017, 18(suppl 1), 952.

9. Fang Liang, Lili Hao, Jianfeng Wang, Shuo Shi, Jingfa Xiao, Rujiao Li*, BS-RNA: An efficient mapping and annotation tool for RNA bisulfite sequencing data. Comput Biol Chem, 2016, 65, 173-77.

10. 赵文明;张思思;唐碧霞;陈婷婷;郝丽丽;桑健;李茹姣;肖景发;章张. 面向国际的生命组学大数据管理体系建设. 大数据, 2016, 06, 43-52.

11. Jinxiu Li, Rujiao Li, Ying Wang, Xiaoxiang Hu, Yiqiang Zhao, Li Li, Chungang Feng, Xiaorong Gu, Fang Liang, Susan J. Lamont, Songnian Hu, Huaijun Zhou, Ning Li, Genome-wide DNA methylome variation in two genetically distinct chicken lines using MethylC-seq. BMC Genomics, 2015, 16, 851. (共同第一作者)

12. Dong Zou, Shixiang Sun, Rujiao Li, Jiang Liu, Jing Zhang, Zhang Zhang, MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. NAR. Nucleic Acids Res. 2015, 43(Database issue), D54-8.

13. Fang Liang, Bixia Tang, Yanqing Wang, JianFeng Wang, Xu Chen, Caixia Yu, Junwei Zhu, Jiangwei Yan, Wenming Zhao, Rujiao Li*, WBSA: Web Service for Bisulfite Sequencing Data Analysis. PLos One, 2014, 9(1), e86707.

14. Zaichao Zhang, Zhong Jin, Yongbing Zhao, Zhewen Zhang, Rujiao Li, Jingfa Xiao, Jiayan Wu, Systematic study on G-protein couple receptor prototypes: did they really evolve from prokaryotic genes? IET Systems Biology, doi:10.1049/iet-syb.2013.0037

15. Zhang Ruosi, Lili Hao, Lingping Wang, Meili Chen, Wen Li, Rujiao Li, Jun Yu, Jingfa Xiao, Jiayan Wu, Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes. BMC Genomics, 2013,14(suppl5), e54082.

16. Wenming Zhao, Wanfei Liu, Dongmei Tian, Bixia Tang, Yanqing Wang, Caixia Yu, Rujiao Li, Yunchao Ling, Jiayan Wu, Shuhui Song, Songnian Hu, wapRNA: a web-based application for the processing of RNA sequences. Bioinformatics, 2012, 27(21), 3076-3077.

17. Ru-Jiao Li, Zhi-Ru Li, Di Wu, Wei Chen, Ying Li, Bing-Qiang Wang, and Chia-Chung Sun, Proton Transfer of NH3-HCl Catalyzed by Only One Molecule. J. Phys. Chem. A, 2005, 109, 629-634.

18. Ru-Jiao Li, Zhi-Ru Li, Di Wu, Xi-Yun Hao, Bing-Qiang Wang, and Chia-Chung Sun, Ab Initio Study of the Interaction Hyperpolarizabilities of HCN-HF and HNC-HF Complexes. J. Phys. Chem. A, 2003, 107, 6306-6310.

19. Ru-Jiao Li, Zhi-Ru Li, Di Wu, Xi-Yun Hao, Ying Li ,Bing-Qiang Wang, Fu-Ming Tao, Chia-Chung Sun, Density functional study of structures and interaction hyperpolarizabilities of NH3-HCl-(H2O)n (n = 0 ~ 4) clusters. Chem. Phys. Lett, 2003, 372, 893.

20. 张蛮,李茹姣,吴迪,孙晓颖,李志儒,孙家钟,F-(H2O)n(n = 1 ~ 4)体系的结构、偶极矩、极化率和一阶超极化率的从头计算,高等学校化学学报,2005, 26, 515-517.

21. 李茹姣,李志儒,吴迪,郝希云,王炳强,一种Cs-NH3-HCl-4H2O 的结构和非线性光学性质的研究,高等学校化学学报,2002, 23, 369.

已申请的著作权:

1. 重亚硫酸盐测序数据分析网络平台,编号:2014R11L058859

2. 差异甲基化区域识别软件,编号:2014R11L058939

3. 5-羟甲基化胞嘧啶测序数据分析软件,编号:2014R11L058975

4. ChIP-seq转录因子分析软件,编号:2014R11L059016

参与翻译书籍:

《第二代测序信息处理》 (英文名:Next-Generation DNA Sequencing Informatics) 科学出版社出版 2014年6月第一次印刷

社会任职:
获奖及荣誉: