王前飞

中国科学院北京基因组研究所

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  • 王前飞
  • 博士生导师、精准基因组医学重点实验室副主任
  • 研究员

王前飞 ( WANG Qianfei )

职 称: 研究员
职 务: 博士生导师、精准基因组医学重点实验室副主任
E-Mail: wangqf@big.ac.cn
学科类别: 基因组学
学习经历:
1988年9月-1993年7月 山东医科大学 临床医学专业 医学学士学位 1997年9月-2002年5月 约翰斯霍普金斯大学 细胞和分子医学专业 理学博士学位
工作经历:

2002年9月-2006年12月 加州大学伯克利分校 博士后研究

2007年1月-2009年6月 芝加哥大学 研究助理教授

2009年7月至今 中国科学院北京基因组研究所 研究员 博士生导师

主要研究领域:
血液学和肿瘤基因组学
承担科研项目情况:

1.国家自然科学基金委重大项目,白血病形成及其在药物作用下的细胞异质性演化,2019年1月-2023年12月,在研,课题负责人

2.中国科学院重点部署项目,经典化疗药物治疗肿瘤的新理论构建和创新应用,2018年9月-2020年8月,在研,项目负责人

3.国家自然科学基金委重大研究计划,肿瘤发生、发展和治疗过程中细胞进化模式及机制研究,2018年1月-2019年12月,在研,子课题负责人

4.国家杰出青年科学基金,急性白血病的基因组学和表观遗传机制研究,2015年1月-2019年12月,在研,项目负责人

5.中国科学院个性化药物战略性先导科技专项,组蛋白甲基转移酶SETD2小分子抑制剂发现及其抗血液肿瘤的个性化功能研究,2018年1月-2019年12月,在研,项目负责人

代表论著:

1. Hu YX, Chen AL , Zheng XC, Lu J, He HL, Yang J, Zhang Y, Sui PP, Yang JY, He FH, Wang Y, Xiao PF, Liu X, Zhou YM, Pei DQ, Cheng C, Ribeiro R C*, Hu SY* and Wang QF*. Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy. National Science Review. 6: 469–479, 2019

2. Yang XJ, Lu YD, He FH, Hou FX, Xing CH*, Xu PY*, Wang QF*. Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-Κb pathway. Carcinogenesis. 2019 Feb 16. pii: bgy157. doi: 10.1093/carcin/bgy157. [Epub ahead of print]

3. Zhang P , He FH, Bai J, Yamamoto S, Chen S, Zhang L, Sheng MY, Zhang L, Guo Y, Man N, Yang H, Wang SY, Cheng T, Nimer SD, Zhou Y, Xu MJ*, Wang QF* and Yang FC*. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 128(12):5383-5398,2018

4. Yang XJ, Lu B, Sun XQ, Han CJ, Fu CL, Xu KL, Wang M, Li DJ, Chen ZC, Opal P, Wen Q, Crispino JD, Wang QF*, Huang Z*. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 32(7):1587-1597,2018

5. Bu JC, Chen AL, Yan XM, He FH, Dong YZ, Zhou YL, He JL, Zhan D, Lin PP, Hayashi Y, Sun YL, Zhang Y, Xiao ZJ, Grimes HL, Wang QF* and Huang G*. SETD2 mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia.32(4):890-899,2018

6. Li YY, Jin C, Bai H, Gao YX, Sun S, Chen L, Qin L, Liu PP, Cheng LZ*, Wang QF*. Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation. Blood. 131(2):191-201,2018

7. Huang L, Liu D, Wang N, Ling SP, Tang YT, Wu J, Hao LT, Luo H, Hu XL, Sheng LS, Zhu LJ, Wang D, Luo Y, Shang Z, Xiao M, Mao X, Zhou KG, Cao LH, Dong LL, Zheng XC, Sui PP, He JL, Mo SL, Yan J, Ao QL, Qiu LG, Zhou HS, Liu QF, Zhang HY, Li JY, Jin J, Fu L, Zhao WL, Chen JP, Du X, Qing GL, Liu HD, Liu X, Huang G, Ma D, Zhou JF*, Wang QF*. Integrated Genomic Analysis Identifies Deregulated JAK/STAT-MYC-Biosynthesis Axis in Aggressive NK-cell Leukemia.Cell Research. 28(2):172-186,2018

8. Zhan D, Zhang YC, Xiao PF, Zheng XC, Ruan M, Zhang JL, Chen AL, Zou Y, Chen YM, Huang G, Hu SY, Wang QF*, Zhu XF*. Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia. Leukemia Research. 65:20-24,2018

9. Zheng M, Lin FL, Hou FX, Li GL, Zhu CY, Xu PY, Xing CH*, Wang QF*. Association between Promoter Methylation of Gene ERCC3 and Benzene Hematotoxicity. Int. J. Environ. Res. Public Health. 14(8):921,2017

10. Li JP, He FH, Zhang P, Chen S, Shi H, Sun YL, Guo Y, Yang H, Man N, Greenblatt S, Li ZM, Guo ZY, Zhou Y, Wang L, Morey L, Williams S, Chen X, Wang QT, Nimer S, Yu P, Wang QF*, Xu MJ* and Yang FC*. Loss of Asxl2 leads to myeloid malignancies in mice. Nature Communications. 2017 Jun 8;8:15456. doi: 10.1038/ncomms15456

11. Yu RX, Liu D, Yang Y, Han YY, Li LR, Zheng LY, Winges DM, Wang J, Zhang Y, Wang QF* and Wang Q*. Expression profiling-based clustering of healthy subjects recapitulates classifications defined by clinical observation in Chinese medicine. Journal of Genetics and Genomics. 44(4):191-7,2017

12. Zhang P, Xing CH, Rhodes SD, He YZ, Deng K, Li ZM, He FH, Zhu CY, Nguyen L, Zhou Y, Chen S, Mohammad K S, Guise TA, Abdel-Wahab O, Xu MJ, Wang QF* and Yang FC*. Loss of asxl1 alters self-renewal and cell fate of bone marrow stromal cell, leading to Bohring-Opitz-like syndrome in Mice. Stem Cell Reports. 6(6):914-925,2016

13. Kang L*, Wu J, Tao Y, Li HL, Liu XL, Gao SR* and Wang QF*. Cell type-specific expression profile and signaling requirements in early hematopoietic reprogramming. Stem Cells Dev. 24(12),1483-1492,2015

14. Chen AL, Yang JY, Hu SY* and Wang QF*. The priming inducton regimen of HAG as a low dose strategy in AML clonal evolution. Sci China Life Sci.58(12),1302-1305,2015

15. Wang QF* and Cheng T*. Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development. Sci China Life Sci. 57(9):944-946,2014

16. Cai J, Miao XX, Li YY, Smith C, Tsang K, Cheng LZ* and Wang QF*. Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells. Stem Cell Reports. 3(2):227-233,2014

17. Zhu XF, He FH, Zeng HM, Ling SP, Chen AL, Wang YQ, Yan XM, Wei W, Pang YK, Cheng H, Hua CL, Zhang Y, Yang XJ, Lu X, Cao LH , Hao LT, Dong LL, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang LX , Mi SL, Wang XJ, Zhang L, Zou Y, Chen YM, Geng Z, Zhou JF, Wang JM, Liu X, Wang JX, Yuan WP, Huang G*, Cheng T* and Wang QF*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature Genetics. 46(3): 287-293,2014

18. Zhou J, Wu J, Li B, Liu D, Yu J, Yan XM, Zheng S, Wang JG, Zhang LX, Zhang L, He FH, Li Q, Chen AL, Zhang Y, Zhao XH, Guan YH, Zhao XH, Yan J, Ni J, Nobrega M, L?wenberg B, Delwel R, Valk P J, Kumar A, Xie L, Tenen DG, Huang G* and Wang QF*. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 28(7): 1436-1448, 2014

19. Wang QF*, Li YJ, Dong JF, Li B, KaberleinJJ, Zhang L, Arimura FE, Luo RT, Ni J, He FH, Wu J, Mattison R, Zhou J, Wang CZ, Prabhakar S, Nobrega M A and Thirman M J*. Regulation of MEIS1 by distal enhancer elements in acute leukemia.Leukemia.28(1):138-146,2014

20. Wang QF, Wu G, Mi SL, He FH, Wu J, Dong JF, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji HK and Thirman MJ. MLL fusion proteins preferentially regulate a subset of wild type MLL target genes in the leukemic genome. Blood.117(25):6895-6905,2011

21. Xing C*, Wang QF*, Li B, Tian H, Ni Y, Yin S and Li G. Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning. Chemico-Biological Interactions. 184:306-309,2010

22. Wang QF*, Prabhakar S, Chanan S, Cheng JF, Rubin EM and Boffelli D*. Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons. Genome Biology. 8(1):R1, 2007

23. Wang QF*, Prabhakar S*, Wang Q, Moses A, Chanan S, Brown M, Eisen M, Cheng JF, Rubin E and Boffelli D. Primate-specific evolution of an LDLR enhancer. Genome Biology.7(8):R68, 2006 (共同第一作者)

24. Wang QF, Liu X, O’nell J, Peng Z, Krauss R, Rainwater DL, Vandeberg JL, Rubin EM, Cheng J F and Pennacchio LA. Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons. Human Molecular Genetics.13(10):1049-1056,2004

25. Wang QF, Cleaves R, Kummalue T, Nerlov C and Friedman A D. Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis. Oncogene. 22(17):2548-2557,2003

26. Wang QF and Friedman A D. C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor. Blood. 99(8):2776-2785, 2002

27. Wang QF, Lauring J, and Schlissel M S. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.Molecular and Cellular Biology.20:9203-9211,2000

社会任职:
中国医师协会临床精准医疗专业委员会委员; 中国研究型医院血液精准委员会副主任委员; 中国医学科学院实验血液学国家重点实验室客座研究员; 中国生理学会血液学专业委员会委员; 儿童血液病与肿瘤分子分型北京市重点实验室学术委员会委员; 分子系统生物学委员会委员
获奖及荣誉:

2014年 国家杰出青年科学基金获得者

2015年 获得中国科学院“朱李月华优秀教师”奖

2015年 入选“国家百千万人才工程”

2016年 国务院政府特殊津贴获得者