杨莹

中国科学院北京基因组研究所

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  • 杨莹
  • 研究员

杨莹 ( YANG Ying )

职 称: 副研究员
职 务:
E-Mail: yingyang@big.ac.cn
学科类别: 基因组学,生物化学与分子生物学
学习经历:
2005年9月-2009年7月 山东大学 生物技术专业 理学学士 2009年9月-2014年7月 中国科学院北京基因组研究所 基因组学专业 理学博士
工作经历:

2018年1月至今 中国科学院北京基因组研究所 副研究员

2014年7月-2017年12月 中国科学院北京基因组研究所 助理研究员

主要研究领域:

RNA表观转录组学研究

承担科研项目情况:

1.国家重点研发计划青年项目,RNA新型修饰调控多能性干细胞初始态和始发态转变机制研究,2018/07-2022/12,在研,骨干; 2.国家自然科学基金面上项目,日本三角涡虫再生RNA表观遗传学研究,2018/01-2021/12,在研,负责人; 3.中国科学院青年创新促进会,在研,负责人; 4.国家自然科学基金青年科学基金项目,RNA 5mC甲基转移酶复合物的鉴定和功能研究,2016/01-2018/12,结题,负责人; 5.科技部国家重大科学研究计划,调控核酸表观遗传修饰的关键因子的发现与作用机制研究,2014/01-2018/12,结题,骨干

代表论著:

1. Ying Yang#, Lu Wang, Xiao Han#, Wen-Lan Yang#, Mengmeng Zhang#, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zhao, Anming Meng, Jinbiao Ma*, Feng Liu*, Yun-Gui Yang*. RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay. Mol Cell 2019 (accepted). (第一作者,IF=14.548) 2. Xin Chen#, Ang Li#, Bao-Fa Sun#, Ying Yang#, Ya-Nan Han#, Xun Yuan#, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang*, Dan Xie*, Yun-Gui Yang*.5-methylcytosine promotes pathogenesis of the bladder cancer through stabilizing mRNAs. Nat Cell Biol 2019 (accepted). (并列第一,IF=17.728) 3. Junchen Chen#, Yichang Zhang#, Chunmin Huang#, Hui Shen, Baofa Sun, Xuejun Cheng, Yujie Zhang, Yungui Yang, Qiang Shu*, Ying Yang*, Xuekun Li*. m6A regulates neurogenesis and neuronal development via modulating histone methyltransferase Ezh2. Genomics Proteomics Bioinformatics 2019; pii: S1672-0229(18)30183-9. (并列通讯,IF=6.597). 4. Ying Yang#, Phillip J. Hsu#, Yu-Sheng Chen, Yun-Gui Yang*. Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res 2018; 28(6): 616–624. (第一作者,IF=17.848). 5. Zeyu Zhang#, Meng Wang#, Donfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Yun-Gui Yang*, Xiu-Jie Wang*. METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation. Cell Res 2018; 28(11):1050-1061. (Cell Res cover story and research highlight) 6. Chen-Xin Wang#, Guan-Shen Cui#, Xiuying Liu#, Kai Xu#, Meng Wang#, Xin-Xin Zhang, Li-Yuan Jiang, Ang Li, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Gui-Bin Jiang, Hai-Lin Wang, Wei-Min Tong, Wei Li, Xiu-Jie Wang*, Yun-Gui Yang*, Qi Zhou*. Mettl3-mediated m6A modification is required for cerebellar development. PLoS Biol 2018;16(6): e2004880. 7. Chunxia Zhang#, Yusheng Chen#, Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Wen Xiao, Yun-Gui Yang*, and Feng Liu*. m6A modulates haematopoietic stem and progenitor cell specification in vertebrates. Nature 2017; 549(7671):273-276. (Highlighted in J Genet Genomics and Sci Signal) (并列第一,IF=43.070) 8. Kai Xu#, Ying Yang#, Gui-Hai Feng#, Bao-Fa Sun#, Jun-Qing Chen#, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou*, Yun-Gui Yang*, Wei Li*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Res 2017; 27(9):1100-1114. (Cell Res封面故事) (并列第一,IF=17.848) 9. Xin Yang#, Ying Yang#, Bao-Fa Sun#, Yu-Sheng Chen#, Jia-Wei Xu#, Wei-Yi Lai#, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang*, Ying-Pu Sun*, Yun-Gui Yang*. 5-methylcytosinepromotes mRNA export- NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res 2017; 27(5):606-625. (Cell Res封面故事,入选Cell Res和Nat Sci Rev研究特色论文评论和F1000)(并列第一,IF=17.848) 10. Ang Li#,Yu-Sheng Chen#,Xiao-Li Ping,Xin Yang,Wen Xiao,Ying Yang,Hui-Ying Sun,Qin Zhu,Poonum Baidya,Xing Wang,Devi Prasad Bhattarai,Yong-Liang Zhao,Bao-Fa Sun,Yun-Gui Yang*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Res 2017; 27(3):444-447. 11. Wen Xiao, Samir Adhikari, Ujwal Dahal, Yu-Sheng Chen, Ya-Juan Hao, Bao-Fa Sun, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Chun-Min Huang, Ying Yang, Guibin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang*. Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing. Mol Cell 2016; 61(4): 507-519. (Spotlight In Trends In Genetics) 12. Tong Chen#, Ya-Juan Hao#, Ying Zhang#, Miao-Miao Li#, Meng Wang, Weifang Han, Yongsheng Wu, Ying Lv, JieHao, Libin Wang, Ang Li, Ying Yang, Kang-Xuan Jin, Xu Zhao, Yuhuan Li, Xiao-Li Ping, Wei-Yi Lai, Li-Gang Wu, Guibin Jiang, Hai-Lin Wang, Lisi Sang, Xiu-Jie Wang*, Yun-Gui Yang*, and Qi Zhou*. m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 2015; 16(3): 289-301.(Cell Stem Cell封面报道及Cell出版社研究特色论文和Abcam月度优秀表观遗传学研究论文) 13. Ying, Yang#, Bao-Fa Sun#, Wen Xiao, Xin Yang, Hui-Ying Sun, Yong-Liang Zhao, Yun-Gui Yang*. Dynamic m6A Modification and Its Emerging Regulatory Role in mRNA Splicing. Sci Bull 2015; 60(1):21-32. (第一作者) 14. Xu Zhao#, Ying Yang#, Bao-Fa Sun#, Yue Shi#, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Gui-Fang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, and Yun-Gui Yang*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res 2014; 24(12): 1403-1419.(Cell Res研究特色论文)(并列第一,IF=17.848) 15. Xu Zhao#, Ying Yang#, Bao-Fa Sun, Yong-Liang Zhao, Yun-Gui Yang*. FTO and obesity: mechanisms of association. Curr Diabetes Rep 2014; 14(5):486. (并列第一,IF=3.996) 16. Bailin Zhao#, Ying Yang#, Xiaoli Wang#, Zechen Chong, Ruichuan Yin, Shu-Hui Song, Chao Zhao, Cuiping Li, Hua Huang, Bao-Fa Sun, Danni Wu, Kang-Xuan Jin, Maoyong Song, Ben-Zhan Zhu, Guibin Jiang, Jannie M. Rendtlew Danielsen, Guo-Liang Xu, Yun-Gui Yang*, Hailin Wang*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res 2014; 42(3):1593-1605. (并列第一,IF=11.147)

社会任职:
中国生物化学与分子生物学会核糖核酸协会青年工作委员会委员 中国细胞生物学学会会员
获奖及荣誉: