张维绮

中国科学院北京基因组研究所

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  • 张维绮
  • 博士生导师
  • 研究员

张维绮 ( ZHANG Weiqi )

职 称: 研究员
职 务: 博士生导师
E-Mail: zhangwq@big.ac.cn
学科类别: 遗传学,基因组学、生物化学与分子生物学、生物信息学
学习经历:
2001年9月-2005年6月,南昌大学,生物工程专业,理学学士学位 2005年9月-2011年6月,北京大学,细胞生物学专业,理学博士学位
工作经历:

2019年2月至今,中国科学院北京基因组所,研究员,博士生导师

2016年12月-2019年1月,中国科学院生物物理研究所,研究员

2015年10月-2016年12月,中国科学院生物物理研究所,副研究员

2011年10月-2015年10月,中国科学院生物物理研究所,助理研究员

主要研究领域:

发育和衰老的表观遗传调控,基于干细胞的疾病模型和药物筛选

承担科研项目情况:
代表论著:

1. Zhang W*, Wan H*, Feng G*, Qu J*, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu G-H and Hu B. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018;560:661-665.(*equal contribution)

2. Zhang W*, Li J*, Suzuki K*, Qu J*, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu G-H and Belmonte JCI. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015;348:1160.(*equal contribution)

3. Kubben N, Zhang W#, Wang L, Voss TC, Yang J, Qu J#, Liu G-H and Misteli T. Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016;165:1361-1374.(#Cosenior author)

4. Zhang W*, Song M*, Qu J and Liu G-H. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018;123:773-786. (*equal contribution)

5. Zhang W, Qu J, Suzuki K, Liu G-H and Belmonte JCI. Concealing cellular defects in pluripotent stem cells. Trends in Cell Biology. 2013;23:587-592.

6. Geng L*, Liu Z*, Zhang W#, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M#, Qu J# and Liu G-H#. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein & Cell. 2018. (#Corresponding author)

7. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu G-H#, Zhang W#, Song M# and Qu J#. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein & Cell. 2018.(#Corresponding author)

8. Li Y*, Zhang W*, Chang L, Han Y, Sun L, Gong X, Tang H, Liu Z, Deng H, Ye Y, Wang Y, Li J, Qiao J, Qu J, Zhang W and Liu G-H. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein & Cell. 2016;7:478-488. (*equal contribution)

9. Wu Z*, Zhang W*, Song M*, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J, Suzuki K, Belmonte JCI and Liu G-H. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein & Cell. 2018;9:333-350. (*equal contribution)

10. Guan D*, Zhang W*, Zhang W, Liu GH and Belmonte JCI. Switching cell fate, ncRNAs coming to play. Cell Death & Disease. 2013;4:e464. (*equal contribution)

11. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M and Deng H. Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation. Cell Stem Cell. 2008;3:475-479.

12. Yang J*, Zhang W*, Jiang W, Sun X, Han Y, Ding M, Shi Y and Deng H. P21cip-Overexpression in the Mouse β Cells Leads to the Improved Recovery from Streptozotocin-Induced Diabetes. PLOS ONE. 2009;4:e8344. (*equal contribution)

13. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J, Tang F and Liu G-H. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017;27:1178.

14. Tong Z, Fan Y, Zhang W, Xu J, Cheng J, Ding M and Deng H. Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling. Cell Research. 2009;19:710.

15. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T, Qu J and Liu G-H. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017;27:483.

16. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J, Tang F and Liu G-H. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research. 2016;26:190.

17. Liu G-H, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR and Belmonte JCI. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nature Communications. 2014;5:4330.

18. Liu G-H, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Iii JY, Esteban CR, Sancho-Martinez I and Belmonte JCI. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012;491:603.

19. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y and Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research. 2010;21:196.

20. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JCI, Chen Z, Wang X, Jiang T, Qu J, Tang F and Liu G-H. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nature Communications. 2015;6:10068.

21. Zhang W*, Guan D*, Qu J, Zhang W and Liu G-H. Non-viral iPSCs: a safe way for therapy? Protein & Cell. 2012;3:241-245. (*equal contribution)

22. Zhang W*, Duan S*, Li Y, Xu X, Qu J, Zhang W and Liu G-H. Converted neural cells: induced to a cure? Protein & Cell. 2012;3:91-97. (*equal contribution)

23. Zhang W*, Ding Z* and Liu G-H. Evolution of iPSC disease models. Protein & Cell. 2012;3:1-4. (*equal contribution)

24. Xu X, Yang J, Fu L, Ren R, Yi F, Suzuki K, Liu K, Ding Z, Qu J, Zhang W, Li Y, Yuan T, Yuan G, Sui L, Guan D, Duan S, Pan H, Wang P, Zhu X, Montserrat N, Li M, Bai R, Liu L, Izpisua Belmonte JC and Liu G-H. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein & Cell. 2014;5:4-7.

25. Wang S, Liu Z, Ye Y, Li B, Liu T, Zhang W, Liu G-H, Zhang YA, Qu J, Xu D and Chen Z. Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell Death & Disease. 2018;9:923.

26. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J, Tang F and Liu G-H. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018;4:2.

27. Wang P*, Zhang W*, Yang J, Qu J and Liu G-H. Higher-order genomic organization in pluripotent stem cells. Protein & Cell. 2012;3:483-486. (*equal contribution)

28. Pan H*, Zhang W*, Zhang W and Liu G-H. Find and replace: editing human genome in pluripotent stem cells. Protein & Cell. 2011;2:950-956. (*equal contribution)

29. Fu L, Xu X, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JCI, Qu J and Liu G-H. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein & Cell. 2016;7:210-221.

30. Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X, Belmonte JCI, Liu G-H, Yi F and Qu J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein & Cell. 2015;6:386-389.

社会任职:
中国细胞生物学学会衰老细胞生物学分会委员 中国老年学会衰老与抗衰老科学委员会委员
获奖及荣誉:

2015年 中国科学院“青年创新促进会”

2015年 中国科协“青年人才托举工程”

2016年 首都十大疾病科技攻关创新型科技进展奖 (团体第三名)

2017年 北京市科学技术二等奖(团体第四名)

2018年 国家优秀青年基金