Francesco Faiola(费凡)

中国科学院生态环境研究中心

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  • Francesco Faiola(费凡)
  • 研究员
  • 北京市海淀区双清路18号
简历:

博士,研究员,博士生导师,中国科学院“百人计划”入选者。 Francesco Faiola研究员于2006年获美国加州大学河滨分校博士学位。2006-2014年先后在美国加州大学河滨分校和美国西奈山伊坎医学院完成博士后学习和深造,在干细胞生物学领域具备深厚的研究背景,相关研究成果发表于Nature、PNAS、Molecular Cells、Cell Research等高水平学术期刊。2014年入选中国科学院“百人计划”,是生态环境研究中心引进的第一位外籍研究员。长期从事胚胎干细胞多能性分子机制及体细胞重编程机制的研究,结合干细胞生物学与环境毒理学的交叉发展趋势,提出了干细胞毒理学的新研究方向。2014年领导建立了国际上率先使用干细胞进行毒理学研究的课题组。

研究方向:
干细胞毒理学
招生方向:
细胞生物学,分子生物学
专家类别:
高级 百人计划
职务:
社会任职:
承担科研项目情况:

1. 中国科学院生态环境研究中心 “百人计划”项目(121311ZXPP2014004 ),2014.03-2017.03 2. 中国科学院战略性先导科技专项(B类)(XDB14040300)典型污染物诱导干细胞癌变的机理,2014.06-2019.05 3. 中国科学院“百人计划”A类(29人字[2015]30号),2015.01-2018.12 4. 国家自然科学基金面上项目(21577166),利用多能干细胞研究环境污染物的健康效应及风险评估,2016.01-2019.12 5. 国家自然科学基金面上项目(21876197),基于人胚胎干细胞胰腺分化模型研究全氟化合物与糖尿病发病的相关性,2019.01-2022.12

获奖及荣誉:
代表论著:

1. Shuyu Liu, Nuoya Yin, and Francesco Faiola*. PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells. Environmental Science & Technology Letters. 2018 5(5), 237-242. 2. Nuoya Yin#, Renjun Yang#, Shaojun Liang, Shengxian Liang, Bowen Hu, Ting Ruan, Francesco Faiola*. Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro, mouse stem cell differentiation model. Chemosphere. 2018, 204, 109-118. #These authors contributed equally. 3. Nuoya Yin#, Shaojun Liang#, Shengxian Liang, Renjun Yang, Bowen Hu, Zhanfen, Qin, Aifeng Liu, Francesco Faiola*. TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways. Environmental Science & Technology. 2018 52 (9), 5459-5468. #These authors contributed equally. 4. Nuoya Yin#, Shengxian Liang#, Shaojun Liang, Bowen Hu, Renjun Yang, Qunfang Zhou, Guibi Jiang, Francesco Faiola*. DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development. Environmental Pollution. 2018, 236:21. #These authors contributed equally. 5. Shuyu Liu, Nuoya Yin, Francesco Faiola*. Prospects and Frontiers of Stem Cell Toxicology. Stem Cells & Development. 2017, 26(21):1528-1539. 6. Francesco Faiola#, Nuoya Yin#, Miguel Fidalgo, Xin Huang, Arven Saunders, Junjun Ding, Diana Guallar, Baoyen Dang, and Jianlong Wang. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression. Stem Cell Reports. 2017, 9(3):913-926. #These authors contributed equally. 7. Faiola F*, Yin N, Yao X, Jiang G. The rise of stem cell toxicology. Environ Sci Technol. 2015 May 19;49(10):5847-8. 8. Yin N, Yao X, Zhou Q, Faiola F*, Jiang G. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats. Biochem Biophys Res Commun. 2015 Mar 6;458(2):405-10. 9. Yin N, Yao X, Qin Z, Wang YL, Faiola F*. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. J Environ Sci (China). 2015 Oct 1;36:181-7. 10. Costa, Y. #, Ding, J. #, Theunissen, T.W. #, Faiola, F. #, Hore, T.A., Shliaha, P.V., Fidalgo, M., Saunders, A., Lawrance, M., Dietmann, S., Das, S., Levasseur, D.N., Li, Z., Xu, M., Reik, W., Silva, J.C.R. & Wang, J*. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013 Mar 21;495(7441):370-4. #These authors contributed equally. 11. Fidalgo M, Faiola F, Pereira CF, Ding J, Saunders A, Gingold J, Schaniel C, Lemischka IR, Silva JC, Wang J*. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U.S.A. 2012 Oct 2;109(40):16202-7. 12. Ding, J., Xu, H.#, Faiola, F.#, Ma’ayan, A. & Wang, J*. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res. 2012 Jan;22(1):155-67. #These authors contributed equally. 13. Saunders A, Faiola F, Wang J*. Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells. 2013 Jul;31(7):1227-36. 14. Wang YL, Faiola F, Martinez E*. Purification of multiprotein histone acetyltransferase complexes. Methods Mol Biol. 2012;809:427-43. 15. Faiola F, Wu YT, Pan S, Zhang K, Farina A, Martinez E*. Max is acetylated by p300 at several nuclear localization residues. Biochem J. 2007 May 1;403(3):397-407. 16. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, Farina A, Martinez E*. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol. 2005 Dec;25(23):10220-34.