1. 利用生物信息学技术为肿瘤研究提供早期诊断和精准治疗的系统解决方案,研发临床上肿瘤亚型分类和肿瘤早期诊断的分子诊断产品。
2. 研究肠道菌群对肿瘤、慢性疾病的影响,研发肠道菌群中可用于特定疾病的早期诊断标记物。
代表论著
[1]Yongchang Zheng, Qianqian Huang, Zijian Ding, Tingting Liu, Chenghai Xue, Xinting Sang, Jin Gu, Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma, Brief Bioinform,bbw094, 2016
[2]Weyn-Vanhentenryck SM, Mele A, Yan Q, Sun S, Farny N, Zhang Z, Xue Chenghai, Herre M, Silver PA, Zhang MQ, Krainer AR, Barnell RB, Zhang C, HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism, Cell Report, 6: 1139-1152, 2014
[3]Qian Zhang, Junping Zhang, Chenghai Xue*, Measuring reproducibility of high-throughput deep-sequencing experiments based on self-adaptive mixture copula, on PAKDD (1) 2013: 301-313
[4]Sarah Djebali, Carrie A. Davis, Angelika Merkel, Alex Dobin, Timo Lassmann, Ali Mortazavi,Andrea Tanzer, Julien Lagarde, Wei Lin, Felix Schlesinger, Chenghai Xue, Georgi K. Marinov, Jainab Khatun, Brian A. Williams, Chris Zaleski, et al.,Thomas R. Gingeras,, Landscape of transcription in human cells, Nature, 489: 101-108, 2012
[5]Chenghai Xue, Fei S. Li, Fei Li, Finding Noncoding RNA Transcripts from Low Abundance Expressed Sequence Tags, Cell Research, 18(6): 695-700, 2008
[6]Peng Tao, Chenghai Xue, Jianning Bi, Tingting Li, Xiaowo Wang, Xuegong Zhang, Yanda Li, Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse, BMC Genomics, 9:191, 2008
[7]Chenghai Xue*, Guo-Ping Liu, RScan: fast searching structural similarities for structured RNAs in large databases, BMC Genomics, 8:257, 2007
[8]Chenghai Xue, Fei Li, Tao He, Guo-Ping Liu, Yanda Li, Xuegong Zhang, Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine, BMC Bioinformatics, 6:310, 2005.
[9]CHEN Zuo-zhou, XUE Cheng-hai, ZHU Sheng, ZHOU Feng-feng, Xuefeng Bruce LING, LIU Guo-ping, CHEN Liang-biao; GoPipe: streamlined gene ontology annotation for batch anonymous sequences with statistics, Progress in Biochemistry and Biophysics, 32(2), 187-191, 2005.
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