2008/04–至今, 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室, 副研究员 中国科学院大学，环境与健康学院，副教授； 2007/03–2008/04, 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室, 助理研究员 2004/12–2006/12, 美国田纳西大学,比较医学系,博士后 2000/08–2004/12, 美国田纳西大学,生态学与进化生物学系,博士 1997/09–2000/07, 中国疾病预防控制中心,硕士 1993/09–1997/07, 南开大学,环境科学系,学士

颗粒物与纳米毒理学

食品药品监管总局食品安全风险交流专家组成员，风险交流专家

1、中国科学院前沿科学重点研究项目,QYZDJ-SSW-DQC020-02,PBDEs对斑马鱼的生殖发育毒性及其机制（课题2）,2016/08-2020/12,75万元,在研,主持 2、国家自然科学基金面上项目,21477146, 几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究,2015/01-2018/12,90万元,在研,主持 3、国家自然科学基金面上项目,21277158,单壁碳纳米管的生物可利用性、生物可降解性及毒性效应,2013/01-2016/12,80万元,已结题,主持 4、国家自然科学基金青年项目,20807054,单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究,2009/01-2011/12,19万元,已结题,主持 5、科技部“973计划”,2009CB421605,PBDE和PFC的毒性效应与分子机制研究（子课题）,2009/01-2013/12,50万元,已结题,主持 6、中国科学院知识创新工程领域前沿项目,RCEES-QN-200714,用基因芯片的方法研究碳纳米管的免疫毒性作用及分子机制,2007/08-2009/07,8.8万元,已结题,主持 7、 国家自然科学基金委员会重大研究计划,91543203,基于颗粒物模型研究PM2.5氧化应激效应的分子机制,2016/01-2019/12,341万元,在研,参加 8、中国科学院战略先导科技专项B,XDB14040100,典型污染物的内分泌干扰效应与发育毒性,2014/07-2019/06,2260万元,在研,参加 9、国家自然科学基金委员会重大项目,20890112,典型持久性有机污染物的累积代谢及其与生物分子的相互作用,2009/01-2012/12,350万元,已结题,参加 10、国家科技重大专项,2009ZX07207-002-03,松花江优先生态风险污染物的生态效应研究,2009/01-2011/12,240万元,已结题,参加 11、科技部“863计划”,2007AA06A407,重大环境污染事件应急技术系统研究开发与应用示范,2007/11-2010/11,120万元,已结题,参加

Yan Xin, Bin Wan* ,Yu Yang, Xue-Jing Cui, Yi-Chun Xie, Liang-Hong Guo*, Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. Archives of Toxicology, 2018, DOI: 10.1007/s00204-018-2266-0 YiChun Xie, Xuejing Cui,Yan Xin,Yu Yang, Bin Wan*, Liang-Hong Guo. Cytotoxicity and autophagy induction by Graphene quantum dots with different functional groups. Journal of Environmental Sciences, 2018, DOI: JES-2018-738. Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. Scientific Reports, 2017, 7, 1518. Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Hui Zhang. Crucial Role of P2X7 Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. Small, 2016, 12:5998-6011. (Cover Article) Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor. Environmental Science & Technology, 2016, 50:12473-12483. Jie Hou, Bin Wan*, Yu Yang, Xiao-Min Ren, Liang-Hong Guo*，and Jing-Fu Liu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. International Journal of Molecular Sciences, 2016, 17:409-426. Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Lixia Zhao, Yu Yang. In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction. Chemosphere, 2015,120: 621-630. Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Yu Yang, Xiao-Min Ren, Hui Zhang. In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. Chemico-Biological Interactions, 2015, 240: 84-93. Ping-Xuan Dong, Bin Wan*, Zi-Xia Wang, Liang-Hong Guo*, Yu Yang & Lixia Zhao. Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. Nanotoxicology, 2013, 7(5): 1028-1042. Bin Wan* , Zi-Xia Wang, Qi-Yan Lv, Ping-Xuan Dong, Li-Xia Zhao, Yu Yang, Liang-Hong Guo*. Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. Toxicology Letters, 2013, 221: 118-127. Ping-Xuan Dong, Bin Wan* and Liang-Hong Guo. In vitro toxicity of acid-functionalized Single-Walled Carbon Nanotubes: Effects on Murine Macrophages and Gene Expression Profiling. Nanotoxicology, 2012, 6(3): 288-303. Bin Wan, Jason W. Yarbrough, T. Wayne Schultz*. Structure-related clustering of gene expression fingerprints of thp-1 cells exposed to smaller polycyclic aromatic hydrocarbons. SAR and QSAR in Environmental Research, 2008, 19 (3-4): 351-373.