赵潇

国家纳米科学中心

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姓      名:
赵潇
职      务:
职      称:
研究员
通讯地址: 北京市海淀区中关村北一条11号

 

简历:

赵潇,研究员。2016年在天津医科大学获得肿瘤学博士学位,指导教师为郝继辉主任医师,其中博士阶段在国家纳米科学中心进行联合培养,指导教师为聂广军研究员。后于2016年至2019年在国家纳米科学中心聂广军研究员组做博士后研究。20199月加入国家纳米科学中心任研究员。主要关注抗肿瘤纳米药物及疫苗的研究,尤其是针对肿瘤临床治疗困境的纳米药物设计合成、mRNA纳米药物及其应用、生物来源纳米颗粒(主要是exosome、细菌外膜囊泡OMV、病毒样颗粒VLP等)及其在肿瘤治疗中的应用。截至2019年在Advanced Materials, Nano Letters, ACS Nano等学术期刊发表论文近30篇,其中第一作者或通讯作者身份共10篇。

研究领域:

针对肿瘤临床治疗困境的纳米药物设计合成、mRNA纳米药物及其应用、生物来源纳米颗粒及其在肿瘤治疗中的应用

代表论著:

 1. Xiao Zhao, Song Gao, et al. Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin, Cancer Research, 2014, 74(9): 2455-2464

 2. Xiao Zhao, Feng Li, et al. Co-delivery of HIF1 alpha siRNA and Gemcitabine via Biocompatible Lipid-polymer Hybrid Nanoparticles for Effective Treatment of Pancreatic Cancer, Biomaterials, 2015, 46: 13-25

 3. Jiayan Lang#, Xiao Zhao#*, et al. Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth. ACS Nano, 2019, 13:2176-2189 (共同第一作者,共同通讯作者)

 4. Xiao Zhao, Xiuchao Wang, et alPrecision Design of Nanomedicines to Restore Gemcitabine Chemosensitivity for Personalized Pancreatic Ductal Adenocarcinoma Treatment. Biomaterials, 2018, 158: 44-55

 5. Feng Li#Xiao Zhao#, et al. Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models, Advanced Functional Materials, 2015, 25(5): 788-798 (共同第一作者)

 6. Xiao Zhao, Liang Liu, et al. A CRISPR-Cas13a System for Efficient and Specific Therapeutic Targeting of Mutant KRAS for Pancreatic Cancer Treatment. Cancer Letters, 2018, 431: 171-181

 7. Xiao Zhao, Xiuchao Wang, et alA Combinatorial Strategy Using YAP and Pan-RAF Inhibitors for Treating KRAS-mutant Pancreatic Cancer. Cancer Letters, 2017, 402: 61-70

8. Xiao Zhao, Keni Yang, et al. Inducing Enhanced Immunogenic Cell Death with Nanocarrier-based Drug Delivery Systems for Pancreatic Cancer, Biomaterials, 2016, 102: 187-197

9. Guangna Liu#, Xiao Zhao#, Yinlong Zhang#, et al. Engineering Biomimetic Platesomes for pH-Responsive Drug Delivery and Enhanced Anti-Tumor Activity. Advanced Materials, 2019 (共同第一作者, In Press)

10. Shaoli Liu#, Yinlong Zhang#, Xiao Zhao#, et al. Tumor-specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-associated Hypercoagulability. Nano Letters, 2019 (共同第一作者, In Press)