吴雁

国家纳米科学中心

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姓       名:
吴雁
职      务:
职      称: 研究员
通讯地址:
北京市海淀区中关村北一条11号

 

简历:

吴雁,研究员,博士生导师。 2003年6月在南开大学高分子化学研究所获得博士学位。2003年8月-2005年6月期间在复旦大学高分子化学系从事博士后研究。 2005年8月加入国家纳米科学中心,2013年4月被聘为研究员。研究方向:主要从事各种功能高分子材料作为药物载体的研究,包括:运用高分子合成、有机合成及纳米技术构建各种功能聚合物纳米粒子(如:两亲性高分子材料的制备、组装),研究其作为药物载体及载药纳米粒体内外生物活性、生物利用度研究;具有多重环境响应的聚合物药物载体的制备及其体内外生物活性及生物利用度研究;具有超分子结构药物载体的构建及其体内外生物活性、生物利用度研究。医用纳米粒子的特性、组装及其作为药物载体的研究;天然生物医用高分子药物载体的化学修饰及其控制释放研究。目前发表SCI论文70余篇,授权专利6项。

研究领域:

纳米药物载体制备、纳米载药系统构建及纳米药物递送研究 

代表论著:

 1.  Xiongwei Deng, Zhaoxia Yin, Jianqing Lu, Xianlei Li, Leihou Shao, Caiyan Zhao, Yishu Yang, Qin Hu,* Yan Wu,* Wang Sheng*. In Situ Monitoring of MicroRNA Replacement Efficacy and Accurate Imaging-Guided Cancer Therapy through Light-Up Inter-Polyelectrolyte Nanocomplexes, Advanced Science, 2018, 5, 1700542-1700556.

 2. Caiyan Zhao, Yujia Tong, Xianlei Li, Leihou Shao, Long Chen, Jianqing Lu, Xiongwei Deng, Xuan Wang, Yan Wu*. Photosensitive Nanoparticles Combining Vascular-Independent Intratumor Distribution and On-Demand Oxygen-Depot Delivery for Enhanced Cancer Photodynamic Therapy, Small, 2018, 14, 1703045-1703055.

 3. Yanping Ding, Shishuai Su, Ruirui Zhang, Leihou Shao, Yinlong Zhang, Bin Wang, Yiye Li, Long Chen, Qun Yu, Yan Wu*, Guangjun Nie*. Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures.Biomaterials, 2017, 113,243-252. 

 4.Caiyan Zhao,Leihou Shao,Jianqing Lu,Xiongwei Deng,Yujia Tong, Yan Wu*. Hybrid Prodrug Nanoparticles with Tumor Penetration and Programmed Drug Activation for Enhanced Chemoresistant Cancer Therapy. ACS Applied Materials & Interfaces, 2017,9,18450-18461.

 5. Leihou Shao, Ruirui Zhang,Jianqing Lu, Caiyan Zhao, Xiongwei Deng, Yan Wu*. Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy. ACS Applied Materials & Interfaces, 2017, 9,1226-1236.

 6. Shishuai Su, Yanping Ding, Yiye Li, Yan Wu*, Guangjun Nie*. Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triplenegative breast cancer. Biomaterials, 2016,80,169-178. 

 7. Xiongwei Deng, Yihui Wang, Fang Zhang, Zhaoxia Yin, Qin Hu, Xiangqian Xiao, Zhixiang Zhou, Yan Wu,* Wang Sheng*, Yi Zeng. Acidic pH-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microRNA modulation in cancer cells. Chemical Communications, 2016,52, 3243-3246.

 8. Caiyan Zhao, Hongzhang Deng, Jing Xu, Shuyi Li, Lin Zhong, Leihou Shao, Yan Wu*, Xing-jie Liang*.“Sheddable” PEG-lipid to balance the contradiction of PEGylation between long circulation and poor uptake. Nanoscale, 2016, 6, 10832-10842. 

 9. Shishuai Su, Yanhua Tian, Yiye Li,Yanping Ding, Tianjiao Ji, Meiyu Wu, Yan Wu,* Guangjun Nie* .“Triple-Punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy. ACSNANO, 2015, 9,1367-1378.   

 10.Xiongwei Deng, Minjun, Jiakun Zhang, Kelei Hu, Zhaoxia Yin, Zhixiang Zhou, Xiangqian Xiao, Yishu Yang, Wang Sheng *,Yan Wu*, Yi Zeng. Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer. Biomaterials, 2014, 35,4333-4344. 

承担科研项目情况:

1.国家重点研发计划项目 2.国家自然科学基金项目 3.横向项目